Abstract: Methods and apparatuses for providing an adjustable flow resistor. The adjustable flow resistor can include a chamber into which fluid is introduced, having an input end and an output end. A flow modifier can be situated within the chamber, between the input end and the output end, to modify a flow rate of the fluid. An adjustable resistance member can be positioned to interact with the flow modifier within the chamber to controllably modify the constant flow rate out of the adjustable flow resistor.

Abstract: Systems and methods for exhausting air from a flow pathway are provided. The systems can include a flow resistor having an input coupled to a fluid source and an outlet to output a fluid at an output flow rate, the flow resistor including an adjustable flow channel for modifying the output flow rate of the fluid flowing through the flow resistor; and a priming device having an elongated portion, the elongated portion being substantially rigid axially and configured for insertion through the outlet of the flow resistor to engage the flow resistor and adjust the output flow rate to allow air to be exhausted from the flow pathway through the flow resistor.

Abstract: Systems and methods for managing flow along a pathway are provided herein. The system and method can include a pump for providing a fluid flow along the pathway, a flow regulator in fluid communication at its input end with the pump and designed to maintain flow therethrough at a substantially constant flow rate, and the pathway being in fluid communication with an output of the flow resistor for directing fluid flow to a destination at the substantially constant flow rate.

Abstract: The systems and methods of the present disclosure provides an independent passive variable resistor that can be interposed between a fluid reservoir at an inlet pressure and receptacle at an outlet pressure. The resistor can adjust resistance to the pressure difference from the input to the output so that the flow rate through it is a constant rate. The resistor can include a moveable element and a biasing mechanism located in a chamber to create a flow channel. Each side of the moveable element is exposed to the inlet and outlet pressures and moves within the flow channel to modify the resistance of the flow through the chamber in response to the pressures. The balance of these forces determines the position moveable element, which interacts with the fluid channel to determine the flow resistance through variable resistor. The biasing mechanism can provide the necessary pressure to establish equilibrium flow rate.

Abstract: The systems and methods of the present disclosure provides an independent passive variable resistor that can be interposed between a fluid reservoir at an inlet pressure and receptacle at an outlet pressure. The resistor can adjust resistance to the pressure difference from the input to the output so that the flow rate through it is a constant rate. The resistor can include a moveable element and a biasing mechanism located in a chamber to create a flow channel. Each side of the moveable element is exposed to the inlet and outlet pressures and moves within the flow channel to modify the resistance of the flow through the chamber in response to the pressures. The balance of these forces determines the position moveable element, which interacts with the fluid channel to determine the flow resistance through variable resistor. The biasing mechanism can provide the necessary pressure to establish equilibrium flow rate.

Abstract: Provided herein are methods and a device for collecting biological samples. In particular, the present disclosure relates to a device designed to specifically capture samples within the target areas of a patient for specific cell collection for particular diagnosis.

Abstract: Apparatus comprising: a sleeve adapted to be slid over the exterior of an endoscope; an aft balloon secured to the sleeve; an inflation/deflation tube carried by the sleeve and in fluid communication with the interior of the aft balloon; a pair of hollow push tubes slidably mounted to the sleeve, the pair of hollow push tubes being connected to one another at their distal ends with a raised push tube bridge, the raised push tube bridge being configured to nest an endoscope therein; and a fore balloon secured to the distal ends of the pair of hollow push tubes, the interior of the fore balloon being in fluid communication with the interiors of the pair of hollow push tubes, wherein the fore balloon is capable of assuming a deflated condition and an inflated condition, and further wherein (i) when the fore balloon is in its deflated condition, an axial opening extends therethrough, the axial opening being sized to receive the endoscope therein, and (ii) when the fore balloon is in its inflated condition, the ax

Abstract: Methods and systems for cell collection. Methods and systems include a collection mechanism being transformable between a collection state having an expanded diameter and a retrieval state where the diameter is less than that of the collection state and a conveyance mechanism having a distal end to which the collection mechanism is attached and designed to place the collection mechanism at a site of interest for cell collection. The Methods and systems also include an activation mechanism to transform the collection mechanism between the collection state and the retrieval state.

Abstract: A device for collecting a biological sample in a subject, the device including an inflatable portion attached to a tubular member, and designed to expand from within the tubular member when inflated and to retract within the tubular member, a surface on the inflatable portion provided with varied thickness to facilitate movement of the inflatable portion between an expanded state and a retracted state, and a plurality of projections on the surface to allow collection of the biological sample when the inflatable portion is in the expanded state.

Abstract: A method for collecting a cell sample, including eosinophil white blood cells in a patient is provided. The method includes advancing to a location in an esophagus associated with eosinophilic esophagitis (EoE), a device provided with a collection portion having a first axial end portion and an inflatable second axial end portion. Thereafter, axially moving the second axial end portion, relative to the first axial end portion, from a collapsed position within the first axial end portion into an expanded position out from the first axial end portion. Once the second axial end portion is in the expanded position, allowing it to engage the location associated with EoE to collect a sample of cells.

Abstract: Apparatus comprising: a sleeve adapted to be slid over the exterior of an endoscope; an aft balloon secured to the sleeve; an inflation/deflation tube carried by the sleeve and in fluid communication with the interior of the aft balloon; a pair of hollow push tubes slidably mounted to the sleeve, the pair of hollow push tubes being connected to one another at their distal ends with a raised push tube bridge, the raised push tube bridge being configured to nest an endoscope therein; and a fore balloon secured to the distal ends of the pair of hollow push tubes, the interior of the fore balloon being in fluid communication with the interiors of the pair of hollow push tubes, wherein the fore balloon is capable of assuming a deflated condition and an inflated condition, and further wherein (i) when the fore balloon is in its deflated condition, an axial opening extends therethrough, the axial opening being sized to receive the endoscope therein, and (ii) when the fore balloon is in its inflated condition, the ax

Abstract: The present invention relates to a catheter construction and method of use suitable for use in navigating within a body lumen or vessel, such as a vein, artery, nasal cavity, esophagus, etc. to assist in the performance of various procedures. The device can include a flexible tubular member having a proximal end, a distal end, and channel extending substantially between the proximal end and the distal end, a stiffening sleeve positioned at the distal end of the tubular member to provide stiffness thereto so that a removable procedural tool can be attached to the tubular member, and an elongated non-elastic tether situated within the channel of the tubular member and secured at one end to the distal end of the member, such that when the tether is held in tension, the tether acts to minimize the tubular member from deviating from a neutral state.

Abstract: The systems and methods of the present disclosure provides an independent passive variable resistor that can be interposed between a fluid reservoir at an inlet pressure and receptacle at an outlet pressure. The resistor can adjust resistance to the pressure difference from the input to the output so that the flow rate through it is a constant rate. The resistor can include a moveable element and a biasing mechanism located in a chamber to create a flow channel. Each side of the moveable element is exposed to the inlet and outlet pressures and moves within the flow channel to modify the resistance of the flow through the chamber in response to the pressures. The balance of these forces determines the position moveable element, which interacts with the fluid channel to determine the flow resistance through variable resistor. The biasing mechanism can provide the necessary pressure to establish equilibrium flow rate.

Abstract: Apparatus comprising: a sleeve adapted to be slid over the exterior of an endoscope; an aft balloon secured to the sleeve; an inflation/deflation tube carried by the sleeve and in fluid communication with the interior of the aft balloon; a pair of hollow push tubes slidably mounted to the sleeve, the pair of hollow push tubes being connected to one another at their distal ends with a raised push tube bridge, the raised push tube bridge being configured to nest an endoscope therein; and a fore balloon secured to the distal ends of the pair of hollow push tubes, the interior of the fore balloon being in fluid communication with the interiors of the pair of hollow push tubes, wherein the fore balloon is capable of assuming a deflated condition and an inflated condition, and further wherein (i) when the fore balloon is in its deflated condition, an axial opening extends therethrough, the axial opening being sized to receive the endoscope therein, and (ii) when the fore balloon is in its inflated condition, the ax

Abstract: Apparatus comprising: a sleeve adapted to be slid over the exterior of an endoscope; an aft balloon secured to the sleeve; an inflation/deflation tube carried by the sleeve and in fluid communication with the interior of the aft balloon; a pair of hollow push tubes slidably mounted to the sleeve, the pair of hollow push tubes being connected to one another at their distal ends with a raised push tube bridge, the raised push tube bridge being configured to nest an endoscope therein; and a fore balloon secured to the distal ends of the pair of hollow push tubes, the interior of the fore balloon being in fluid communication with the interiors of the pair of hollow push tubes, wherein the fore balloon is capable of assuming a deflated condition and an inflated condition, and further wherein (i) when the fore balloon is in its deflated condition, an axial opening extends therethrough, the axial opening being sized to receive the endoscope therein, and (ii) when the fore balloon is in its inflated condition, the ax

Abstract: Apparatus comprising: a sleeve adapted to be slid over the exterior of an endoscope; an aft balloon secured to the sleeve; an inflation/deflation tube carried by the sleeve and in fluid communication with the interior of the aft balloon; a pair of hollow push tubes slidably mounted to the sleeve, the pair of hollow push tubes being connected to one another at their distal ends with a raised push tube bridge, the raised push tube bridge being configured to nest an endoscope therein; and a fore balloon secured to the distal ends of the pair of hollow push tubes, the interior of the fore balloon being in fluid communication with the interiors of the pair of hollow push tubes, wherein the fore balloon is capable of assuming a deflated condition and an inflated condition, and further wherein (i) when the fore balloon is in its deflated condition, an axial opening extends therethrough, the axial opening being sized to receive the endoscope therein, and (ii) when the fore balloon is in its inflated condition, the ax