Abstract: A golf club head having a slot in the sole filled with an insert in which the slot is positioned close to the striking face. The slot can be a uniform distance from the striking face or the slot can curve away from the striking face in the toe region. The insert can have a uniform height or a non-uniform height. Inserts with uniform heights can have a low height profile. Inserts with non-uniform heights can have a lower height in a central portion of the insert compared to an edge portion or a perimeter portion of the insert. The insert can also have flanges or protrusions for installation into the slot. The resulting golf club head improves performance, as the sole slot with insert allows the striking face to have a profile that meets the needs at that location.

Abstract: Electro-optic (EO) devices having an EO polymer core comprising a first host polymer and a first nonlinear optical chromophore (NLOC); and a cladding comprising a second host polymer and a second NLOC, and methods of preparing the same; wherein the first NLOC has a first bridge covalently bonded to an electron-accepting group and an electron-donating group; wherein the second NLOC has a second bridge covalently bonded to an electron-accepting group and an electron-donating group; and wherein the second bridge is less conjugated than the first bridge such that the cladding has an index of refraction that is less than that of the EO polymer core, and wherein the second NLOC is present in the second host polymer in a concentration such that the cladding has a conductivity equal to or greater than at least 10% of the conductivity of the EO polymer core at a poling temperature.

Abstract: The present invention relates to a golf club head having an adjustable weight assembly. More specifically, the adjustable weight assembly utilizes a weight member that's secured via a fastener along various positions within an elongate channel.

Abstract: The present disclosure relates to a pharmaceutical composition comprising: (a) ?-lactam antibiotics and (b) a metallo-?-lactamases (MBLs) inhibitor. The inhibitor relates to Bi(III) compounds or the pharmaceutically acceptable salts thereof. The present patent also provides methods of making Bi(III) compounds or the pharmaceutically acceptable salts thereof. Also provided is a method for treating MBLs-producing bacterial infection using a metal replacement mechanism.

Abstract: The present disclosure relates to a pharmaceutical composition comprising: (a) ?-lactam antibiotics and (b) a metallo-?-lactamases (MBLs) inhibitor. The inhibitor relates to Bi(III) compounds or the pharmaceutically acceptable salts thereof. The present patent also provides methods of making Bi(III) compounds or the pharmaceutically acceptable salts thereof. Also provided is a method for treating MBLs-producing bacterial infection using a metal replacement mechanism.

Abstract: The present invention provides a compound as shown in formula (I), formula (II), or formula (III), which can inhibit the binding of influenza virus PB2 protein to RNA cap and has an anti-influenza effect.

Abstract: The present disclosure relates to a pharmaceutical composition comprising: (a) ?-lactam antibiotics and (b) a metallo-?-lactamases (MBLs) inhibitor. The inhibitor relates to Bi(III) compounds or the pharmaceutically acceptable salts thereof. The present patent also provides methods of making Bi(III) compounds or the pharmaceutically acceptable salts thereof. Also provided is a method for treating MBLs-producing bacterial infection using a metal replacement mechanism.

Abstract: A cloud based collaborative work environment enables users to work collaboratively within a shared workspace. An application server on a host device is accessible to client devices via a communication network and maintains the shared workspace for collaboration between users. Client applications hosted on client devices enable users of the workspace to access and make changes in the shared workspace, such as adding or deleting items to or from the workspace, editing or annotating existing items, viewing items in the workspace, or downloading items in the workspace. Local copies of the shared workspace are maintained by the client devices and are synchronized with the shared workspace maintained by the application server so that any changes made to by a user to its local copy of the shared workspace are propagated to other users. Thus, synchronization is maintained between master workspace and the local workspaces on the client devices.

Abstract: The present disclosure relates to a pharmaceutical composition comprising: (a) ?-lactam antibiotics and (b) a metallo-?-lactamases (MBLs) inhibitor. The inhibitor relates to Bi(III) compounds or the pharmaceutically acceptable salts thereof. The present patent also provides methods of making Bi(III) compounds or the pharmaceutically acceptable salts thereof. Also provided is a method for treating MBLs-producing bacterial infection using a metal replacement mechanism.

Abstract: A network-based chat server provides a virtual chat room for chat participants, and synchronizes and shares chat dialogue exchanged between the chat participants regardless of whether the chat participants are logged onto the same chat platform or different chat platforms. The chat server includes a plurality of chat proxies; each of which is configured to communicate data with a particular chat platform. A chat synchronizer function executing at the chat server communicates the chat dialogue between the chat participants via the chat proxies.

Abstract: A cloud based collaborative work environment enables users to work collaboratively within a shared workspace. An application server on a host device is accessible to client devices via a communication network and maintains the shared workspace for collaboration between users. Client applications hosted on client devices enable users of the workspace to access and make changes in the shared workspace, such as adding or deleting items to or from the workspace, editing or annotating existing items, viewing items in the workspace, or downloading items in the workspace. Local copies of the shared workspace are maintained by the client devices and are synchronized with the shared workspace maintained by the application server so that any changes made to by a user to its local copy of the shared workspace are propagated to other users. Thus, synchronization is maintained between master workspace and the local workspaces on the client devices.

Abstract: An intraocular lens with a hydrophilic polymer coating composition and method of preparing same are provided. Specifically, a composition suitable for reducing tackiness in intraocular lenses is provided wherein an acrylic intraocular lens is treated by vapor deposition with an alkoxy silyl terminated polyethylene glycol polymer composition.

Abstract: An intraocular lens with a hydrophilic polymer coating composition and method of preparing same are provided. Specifically, a composition suitable for reducing tackiness in intraocular lenses is provided wherein an acrylic intraocular lens is treated by vapor deposition with an alkoxy silyl terminated polyethylene glycol polymer composition.

Abstract: This invention involves a plasma treated and controllable release antimicrobial peptide coated titanium alloy for surgical implantation, where the alloy with antimicrobial properties is fabricated using surface techniques without adversely compromising its biocompatibility and original mechanical properties. The surface techniques form antimicrobial layers on the alloy capable of resisting microbial adhesion and proliferation, while allowing mammalian cell adhesion and proliferation when the alloy is implanted to human body. In one embodiment, PIII&D is applied to incorporate ions, electrons, free radicals, atoms or molecules on a titanium alloy substrate. A pressurized hydrothermal treatment can be carried out to establish reactive functional groups for antimicrobial purpose or for connecting the substrate and external antimicrobial molecules.

Abstract: An intraocular lens with a hydrophilic polymer coating composition and method of preparing same are provided. Specifically, a composition suitable for reducing tackiness in intraocular lenses is provided wherein an acrylic intraocular lens is treated by vapor deposition with an alkoxy silyl terminated polyethylene glycol polymer composition.

Abstract: We have devised an apparatus useful for and a method of removing impurities from vaporous precursor compositions used to generate reactive precursor vapors from which thin films/layers are formed under sub-atmospheric conditions. The method is particularly useful when the layer deposition apparatus provides for precise addition of quantities of different combinations of reactants during a single step or when there are a number of different individual steps in the layer formation process, where the presence of impurities has a significant affect on both the quantity of reactants being charged and the overall composition of the reactant mixture from which the layer is deposited. The method is particularly useful when the vapor pressure of a liquid reactive precursor is less than about 250 Torr at atmospheric pressure.

Abstract: An improved vapor-phase deposition method and apparatus for the application of multilayered films/coatings on substrates is described. The method is used to deposit multilayered coatings where the thickness of an oxide-based layer in direct contact with a substrate is controlled as a function of the chemical composition of the substrate, whereby a subsequently deposited layer bonds better to the oxide-based layer. The improved method is used to deposit multilayered coatings where an oxide-based layer is deposited directly over a substrate and a SAM organic-based layer is directly deposited over the oxide-based layer. Typically a series of alternating layers of oxide-based layer and organic-based layer are applied.

Abstract: An improved vapor-phase deposition method and apparatus for the application of multilayered films/coatings on substrates is described. The method is used to deposit multilayered coatings where the thickness of an oxide-based layer in direct contact with a substrate is controlled as a function of the chemical composition of the substrate, whereby a subsequently deposited layer bonds better to the oxide-based layer. The improved method is used to deposit multilayered coatings where an oxide-based layer is deposited directly over a substrate and a SAM organic-based is directly deposited over the oxide-based layer. Typically a series of alternating layers of oxide-based layer and organic-based layer are applied.

Abstract: An improved vapor-phase deposition method and apparatus for the application of multilayered films/coatings on substrates is described. The method is used to deposit multilayered coatings where the thickness of an oxide-based layer in direct contact with a substrate is controlled as a function of the chemical composition of the substrate, whereby a subsequently deposited layer bonds better to the oxide-based layer. The improved method is used to deposit multilayered coatings where an oxide-based layer is deposited directly over a substrate and an organic-based layer is directly deposited over the oxide-based layer. Typically, a series of alternating layers of oxide-based layer and organic-based layer are applied.