Patents by Inventor Richard Yi Tsun Kao

Richard Yi Tsun Kao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bismuth(III) compounds and methods thereof
    Patent number: 10624871
    Abstract: The present disclosure relates to a pharmaceutical composition comprising: (a) ?-lactam antibiotics and (b) a metallo-?-lactamases (MBLs) inhibitor. The inhibitor relates to Bi(III) compounds or the pharmaceutically acceptable salts thereof. The present patent also provides methods of making Bi(III) compounds or the pharmaceutically acceptable salts thereof. Also provided is a method for treating MBLs-producing bacterial infection using a metal replacement mechanism.
    Type: Grant
    Filed: January 8, 2019
    Date of Patent: April 21, 2020
    Assignee: THE UNIVERSITY OF HONG KONG
    Inventors: Hongzhe Sun, Richard Yi Tsun Kao, Runming Wang, Tsz Pui Lai, Hongmin Zhang, Hongyan Li
  • BISMUTH(III) COMPOUNDS AND METHODS THEREOF
    Publication number: 20190201370
    Abstract: The present disclosure relates to a pharmaceutical composition comprising: (a) ?-lactam antibiotics and (b) a metallo-?-lactamases (MBLs) inhibitor. The inhibitor relates to Bi(III) compounds or the pharmaceutically acceptable salts thereof. The present patent also provides methods of making Bi(III) compounds or the pharmaceutically acceptable salts thereof. Also provided is a method for treating MBLs-producing bacterial infection using a metal replacement mechanism.
    Type: Application
    Filed: January 8, 2019
    Publication date: July 4, 2019
    Inventors: Hongzhe SUN, Richard Yi Tsun KAO, Runming WANG, Tsz Pui LAI, Hongmin ZHANG, Hongyan LI
  • Compound that Inhibits Binding of Influenza-Virus PB Subunit to RNA Cap
    Publication number: 20190142785
    Abstract: The present invention provides a compound as shown in formula (I), formula (II), or formula (III), which can inhibit the binding of influenza virus PB2 protein to RNA cap and has an anti-influenza effect.
    Type: Application
    Filed: April 12, 2017
    Publication date: May 16, 2019
    Applicant: Sinoclone Ltd.
    Inventors: Bojian ZHENG, Shuofeng YUAN, Richard Yi Tsun KAO, Jie ZHOU
  • Bismuth(III) compounds and methods thereof
    Patent number: 10201518
    Abstract: The present disclosure relates to a pharmaceutical composition comprising: (a) ?-lactam antibiotics and (b) a metallo-?-lactamases (MBLs) inhibitor. The inhibitor relates to Bi(III) compounds or the pharmaceutically acceptable salts thereof. The present patent also provides methods of making Bi(III) compounds or the pharmaceutically acceptable salts thereof. Also provided is a method for treating MBLs-producing bacterial infection using a metal replacement mechanism.
    Type: Grant
    Filed: September 28, 2016
    Date of Patent: February 12, 2019
    Assignee: THE UNIVERSITY OF HONG KONG
    Inventors: Hongzhe Sun, Richard Yi Tsun Kao, Runming Wang, Tsz Pui Lai, Hongmin Zhang, Hongyan Li
  • Bismuth(III) Compounds and Methods Thereof
    Publication number: 20180085335
    Abstract: The present disclosure relates to a pharmaceutical composition comprising: (a) ?-lactam antibiotics and (b) a metallo-?-lactamases (MBLs) inhibitor. The inhibitor relates to Bi(III) compounds or the pharmaceutically acceptable salts thereof. The present patent also provides methods of making Bi(III) compounds or the pharmaceutically acceptable salts thereof. Also provided is a method for treating MBLs-producing bacterial infection using a metal replacement mechanism.
    Type: Application
    Filed: September 28, 2016
    Publication date: March 29, 2018
    Inventors: Hongzhe SUN, Richard Yi Tsun KAO, Runming WANG, Tsz Pui LAI, Hongmin ZHANG, Hongyan LI
  • ANTIBACTERIAL SURFACE AND METHOD OF FABRICATION
    Publication number: 20110046747
    Abstract: This invention involves a plasma treated and controllable release antimicrobial peptide coated titanium alloy for surgical implantation, where the alloy with antimicrobial properties is fabricated using surface techniques without adversely compromising its biocompatibility and original mechanical properties. The surface techniques form antimicrobial layers on the alloy capable of resisting microbial adhesion and proliferation, while allowing mammalian cell adhesion and proliferation when the alloy is implanted to human body. In one embodiment, PIII&D is applied to incorporate ions, electrons, free radicals, atoms or molecules on a titanium alloy substrate. A pressurized hydrothermal treatment can be carried out to establish reactive functional groups for antimicrobial purpose or for connecting the substrate and external antimicrobial molecules.
    Type: Application
    Filed: February 16, 2010
    Publication date: February 24, 2011
    Inventors: Kelvin Wai Kwok Yeung, Kenneth Man Chee Cheung, Keith Dip Kei Luk, Che Yan Yeung, Richard Yi Tsun Kao, Paul Kim Ho Chu