Abstract: Disclosed are methods of altering expression of a gene with a promoter region CTCF binding site. Also disclosed are compositions and methods useful for treating a disease or condition involving over-expression or under-expression of a gene with a promoter region CTCF binding site. Further disclosed are cells and non-human animals with modified a promoter region CTCF binding site, as well as methods for screening for compounds that can modify the expression of a gene with a promoter region CTCF binding site.

Abstract: A storage system configured for use with an energy management system is provided herein and comprises a rechargeable battery, a grid detection circuit operably connected to the rechargeable battery such that when an AC power source is not detected by the grid detection circuit and a voltage at the rechargeable battery falls below a threshold voltage, the grid detection circuit places the rechargeable battery into a sleep mode, and a switch operably connected to the grid detection circuit and configured to override the grid detection circuit so that rechargeable battery exits the sleep mode until a voltage at the rechargeable battery is equal to or greater than a predetermined voltage.

Abstract: A communication system, including a first carrier and a first antenna mounted on the first carrier; a second carrier and a second antenna mounted on the second carrier, wherein the first antenna and the second antenna are arranged relative to each other that the first antenna and the second antenna can establish wireless link; a third carrier and a third antenna mounted on the third carrier; a fourth carrier and a fourth antenna mounted on the fourth carrier, wherein the third antenna and the fourth antenna are arranged relative to each other that the third antenna and the fourth antenna can establish wireless link; and a transmission structure, within which the signal propagate through, connects the second antenna and the third antenna.

Abstract: Methods and systems for implementing artificial intelligence enabled preparation end-pointing are disclosed. An example method at least includes obtaining an image of a surface of a sample, the sample including a plurality of features, analyzing the image to determine whether an end point has been reached, the end point based on a feature of interest out of the plurality of features observable in the image, and based on the end point not being reached, removing a layer of material from the surface of the sample.

Abstract: The present disclosure relates to processes, methods, systems, and apparatus for steam cracking hydrocarbon in a pyrolysis furnace having a convection zone and a radiant zone. The convection zone includes three heat exchangers in series with a serpentine arrangement. A fluid source is disposed each heat exchanger to provide steam into the heat exchangers. The present disclosure further relates to a process of adjusting the stream flow rate for each fluid source to control operating conditions such as flue gas temperature, stack temperatures, and temperatures of other components of the furnace.

Abstract: The invention relates to methods of modulating the expression of one or more genes in a cell by modulating the multimerization of a transcription factor and/or modulating the formation of enhancer-promoter DNA loops, and thereby modulating the expression of the one or more genes. The invention also relates to treating diseases and conditions involving aberrant gene expression by modulating the multimerization of a transcription factor and/or modulating the formation of enhancer-promoter DNA loops. The invention also relates to methods for screening for compounds that modulate expression of one or more genes in a cell.

Abstract: Methods and systems for implementing artificial intelligence enabled preparation end-pointing are disclosed. An example method at least includes obtaining an image of a surface of a sample, the sample including a plurality of features, analyzing the image to determine whether an end point has been reached, the end point based on a feature of interest out of the plurality of features observable in the image, and based on the end point not being reached, removing a layer of material from the surface of the sample.

Abstract: A propulsion system includes two gas turbine engines and an air-provisioning system. The air-provisioning system includes a first ejector, a second ejector, a plenum fluidically connected with the first ejector and the second ejector, and a first propulsor. The air-provisioning system is configured to bleed and mix air from each gas turbine engine in the ejectors so as to provide selectively a flow of plenum air from the plenum to the first propulsor at a desired pressure and a desired flow rate to power the first propulsor.

Abstract: Techniques regarding providing artificial intelligence problem descriptions are provided. For example, one or more embodiments described herein can comprise a system, which can comprise a memory that can store computer executable components. The system can also comprise a processor, operably coupled to the memory, and that can execute the computer executable components stored in the memory. The computer executable components can include, at least: a query component that generates key performance indicators from a query, determines a subset of key performance indicators that individually have a performance below a threshold, and maps the subset of key performance indicators to operational metrics; a learning component that generates, using artificial intelligence, problem descriptions from one or more of the subset of key performance indicators or the operational metrics and transmits the problem descriptions to a database.

Abstract: A smoking article filter includes a recess to receive a filter insert unit. The filter insert unit is secured to the filter once inserted. The filter and the filter insert unit may include additives such as flavourants, colourants or sorbents.

Abstract: The invention provides compositions and methods of use in reprogramming somatic cells. Compositions and methods of the invention are of use, e.g., for generating or modulating (e.g., enhancing) generation of induced pluripotent stem cells by reprogramming somatic cells. The reprogrammed somatic cells are useful for a number of purposes, including treating or preventing a medical condition in an individual. The invention further provides methods for identifying an agent that reprograms somatic cells to a pluripotent state and/or enhances the speed and/or efficiency of reprogramming. Certain of the compositions and methods relate to modulating the Wnt pathway.

Abstract: Techniques regarding providing artificial intelligence problem descriptions are provided. For example, one or more embodiments described herein can comprise a system, which can comprise a memory that can store computer executable components. The system can also comprise a processor, operably coupled to the memory, and that can execute the computer executable components stored in the memory. The computer executable components can include, at least: a query component that generates key performance indicators from a query, determines a subset of key performance indicators that individually have a performance below a threshold, and maps the subset of key performance indicators to operational metrics; a learning component that generates, using artificial intelligence, problem descriptions from one or more of the subset of key performance indicators or the operational metrics and transmits the problem descriptions to a database.

Abstract: Provided herein are methods of screening for agents that can partition in viral condensates and therefore may be effective anti-viral agents. Also disclosed are methods of optimizing the activity and reducing the side effects of known or suspected anti-viral agents by screening the portioning of modified known or suspected anti-viral agents in viral condensates and other condensates occurring in cells (e.g., transcriptional condensates).

Abstract: A smoking article filter includes a recess to receive a filter insert unit. The filter insert unit is secured to the filter once inserted. The filter and the filter insert unit may include additives such as flavourants, colourants or sorbents.

Abstract: Described herein are methods of characterizing agent incorporation into condensates, methods of reducing transcription of oncogenes associated with condensates, and methods of using peptides to inhibit nuclear receptor and cofactor binding in condensates.

Abstract: An insertable filter unit for insertion into a smoking article filter having a recess, wherein the insertable filter unit includes an outer casing defining a cavity for storing a smoke modifying agent, and wherein the insertable filter unit is arranged to be inserted into the recess of the smoking article filter by a user.

Abstract: Packaging for an attachable unit for a smoking article The invention relates to packaging (300) for an attachable unit (3) for a smoking article (2) comprising a receiver (301) to receive an attachable unit and a guide (306) for aligning the smoking article with the attachable unit when the attachable unit is received by the receiver such that the attachable unit can be attached to the smoking article. The invention also relates to packaging for an attachable unit for a smoking article comprising a receptacle or receiver in which the attachable unit is receivable and a gripping mechanism (307) to releasably hold the attachable unit within the receptacle or receiver when the attachable unit is received in the receptacle or receiver.

Abstract: Disclosed are methods for identifying the core regulatory circuitry or cell identity program of a cell or tissue, and related methods of diagnoses, screening, and treatment involving the core regulatory circuitry and/or cell identity programs identified using the methods.

Abstract: Described herein are compositions and methods for modulating gene regulation by modulating condensate formation, composition, maintenance, dissolution and regulation.

Abstract: The invention provides compositions and methods of use in reprogramming somatic cells. Compositions and methods of the invention are of use, e.g., for generating or modulating (e.g., enhancing) generation of induced pluripotent stem cells by reprogramming somatic cells. The reprogrammed somatic cells are useful for a number of purposes, including treating or preventing a medical condition in an individual. The invention further provides methods for identifying an agent that reprograms somatic cells to a pluripotent state and/or enhances the speed and/or efficiency of reprogramming. Certain of the compositions and methods relate to modulating the Wnt pathway.