Abstract: A frame structure absorbs energy from frontal impacts and extends under a front portion of the body frame. The frame structure includes a rear sub-frame located below and in front of a pair of side frame under-members, and an inverter protection brace extending between the front sub-frame and the rear sub-frame. Loading from the inverter protection brace travels through the rear sub-frame to A-point bolt connections located on the pair of front frame side members. The rear sub-frame moves rearward and deforms at the A-point bolt connections. The load through the A-point bolt connections changes the deformation mode of the frame front side members between the A-point bolt connections and B-point bolt connections. At least one of the pair of side frame under-members buckles rearward of the B-point bolt connection located on the pair of side frame under-members for energy absorption during the frontal impact.

Abstract: A vehicle frame includes an inverter protection brace extending between front and rear sub-frames located below and in front of side frame members. A gusset of the brace strongly connects to the front sub-frame to load a beam section without overloading the bolts, and a bolted connection attaches to the rear sub-frame. The brace deforms forward of the bolted connection creating a safety cage around an inverter during frontal impacts. A reinforcement bracket attaches to the side frame members to define a pocket for temporarily catching the rear sub-frame. Ramps connect to the reinforcement bracket allowing sliding of the rear sub-frame rearward, and direct movement downwardly beneath a battery assembly. A catching surface defined on a ramp engages at least one rear sub-frame attached structure. A tether connects between the pair of side frame under-members and the rear sub-frame for improving the interaction of the rear sub-frame against the ramps.

Abstract: A frame structure is adapted to absorb energy from frontal impacts and extends under a front portion of the body frame. The frame structure includes a rear sub-frame located below and in front of a pair of side frame under-members, and at least one ramp connected to the pair of side frame under-members for directing rearward sliding movement of the rear sub-frame and attached structures downwardly beneath a battery assembly. A catching surface engages a steering gear to improve energy absorption during frontal impacts. A reinforcement bracket attached to the pair of side frame under-members defines a pocket for temporarily catching the rear sub-frame providing an energy absorption path before releasing the rear sub-frame to slide past. A tether is connected between the pair of side frame under-members and the rear sub-frame for holding the rear sub-frame against the ramp to increase energy absorption.

Abstract: A frame structure is adapted to absorb energy from frontal impacts and extends under a front portion of the body frame. The frame structure includes a rear sub-frame located below and in front of a pair of side frame under-members, and a reinforcement bracket attached to the pair of side frame under-members to facilitate formation and control a deformation shape an energy absorption pocket in the side frame under-member during a frontal impact for temporarily restraining the rear sub-frame providing an energy absorption path before releasing the rear sub-frame to slide past the reinforcement bracket. The energy absorption pocket is formed in the side frame under-member forward of and outboard of the reinforcement bracket during a frontal impact prior to the rear sub-frame be released from a B-point bolt connection to the side frame under-member.

Abstract: A frame structure is adapted to absorb energy from frontal impacts and extends under a front portion of the body frame. The frame structure includes a rear sub-frame located below and in front of a pair of side frame under-members, and a tether is connected between the pair of side frame under-members and the rear sub-frame for prolonging proximity of the rear sub-frame with the side frame under-members. A noise-vibration, ride and handling bracket can be modified to define the tether. The tether attaches to the pair of side frame under-members at two outboard locations and to the rear sub-frame at the two inboard locations positioned forward of the outboard locations. The tether attaches to the pair of side frame under-members providing a limited degree of rotary displacement away from the side frame under-members.

Abstract: Impact protection structures for vehicles are described. An impact protection structure includes a support structure of the vehicle, an interior rail coupled to the support structure, and an exterior rail coupled to the interior rail. The exterior rail has an inboard boundary wall positioned between an upper mounting region and a lower mounting region. The upper and the lower exterior mounting region of the exterior rail are coupled to an upper and a lower mounting region of the interior rail. At least a portion of the inboard boundary wall is spaced apart from an outboard wall of the interior rail such that when the exterior rail is impacted by a blunt-object barrier, the inboard boundary wall of the exterior rail deforms, thereby damping energy of the impact at the exterior rail and arresting crack propagation between the exterior rail and the interior rail.

Abstract: A frame structure absorbs energy from frontal impacts and extends under a front portion of the body frame. The frame structure includes a rear sub-frame located below and in front of a pair of side frame under-members, and an inverter protection brace extending between the front sub-frame and the rear sub-frame. Loading from the inverter protection brace travels through the rear sub-frame to A-point bolt connections located on the pair of front frame side members. The rear sub-frame moves rearward and deforms at the A-point bolt connections. The load through the A-point bolt connections changes the deformation mode of the frame front side members between the A-point bolt connections and B-point bolt connections. At least one of the pair of side frame under-members buckles rearward of the B-point bolt connection located on the pair of side frame under-members for energy absorption during the frontal impact.

Abstract: A tool for use in cutting a tie wrap that is bound about at least one wire and a method of operating the tool. The tool includes a housing having a first side and a second side, wherein the first side and the second side are coupled together to define a cavity. The housing further includes a groove formed in the first side and in the second side, wherein the groove is in flow communication with the cavity. A blade is coupled to the first side and positioned with the cavity, wherein the blade includes a cutting surface partially extending into the groove. The tool also includes a spacer coupled to the housing and configured to maintain the wire a distance away from the cutting surface when the housing is applied to the tie wrap.

Abstract: A cutting tool and method of operating cutting tool. The tool includes a support having a first side and a second side. The tool further includes a handle coupled to at least one of the first side and the second side. The handle includes a blade, wherein the handle is configured to move the blade between a first position and a second position. An alignment guide is coupled to the support. The alignment guide includes a channel configured to receive the blade positioned in the second position.

Abstract: An impact test fixture includes a rolling frame structure, a ballast attachment feature coupled to the rolling frame structure, a position-adjustable attachment assembly coupled to the rolling frame structure, and a specimen attachment member coupled to the position-adjustable attachment assembly. The specimen attachment member is adjustable in a vertical direction and a transverse direction relative to the rolling frame structure.

Abstract: Embodiments of silicone hydrogels, ophthalmic lenses made therefrom, and methods of making the same are described. Fully hydrated silicone hydrogels have relatively high water content and oxygen permeability, along with relatively low modulus of elasticity. Embodiments of the silicone hydrogels in substantially dehydrated condition are adapted to lathe cutting at or above room temperature. Variations of the silicone hydrogels include silicon-containing monomers in an amount greater than 25% by weight, a hydrophilic substituted N-vinyl acetamide monomer in an amount greater than 30% by weight, and a hydrophilic non-acetamide monomer in an amount resulting in a hydrophilic substituted N-vinyl acetamide monomer to hydrophilic non-acetamide monomer weight to weight ratio of greater than 2.1 to 1.

Abstract: In some aspects, the present invention provides compositions and methods relating at least in part to modulation of the Cohesin-Mediator interaction. The invention provides compositions and methods useful for modulating Cohesin-Mediator function. The invention further provides compositions and methods useful for identifying compounds that modulate Cohesin-Mediator function. In some aspects, the invention provides compositions and methods useful for treating a disorder involving altered Cohesin-Mediator function.

Abstract: In some aspects, the invention provides compositions and methods of use for treating a variety of diseases. In some aspect, the compositions and methods involve combined modulation of transcriptional modulators.

Abstract: Embodiments of silicone hydrogels, ophthalmic lenses made therefrom, and methods of making the same are described. Fully hydrated silicone hydrogels have relatively high water content and oxygen permeability, along with relatively low modulus of elasticity. Embodiments of the silicone hydrogels in substantially dehydrated condition are adapted to lathe cutting at or above room temperature. Variations of the silicone hydrogels include silicon-containing monomers in an amount greater than 25% by weight, a hydrophilic substituted N-vinyl acetamide monomer in an amount greater than 30% by weight, and a hydrophilic non-acetamide monomer in an amount resulting in a hydrophilic substituted N-vinyl acetamide monomer to hydrophilic non-acetamide monomer weight to weight ratio of greater than 2.1 to 1.

Abstract: A lens accessory for a video game sensor device and a method of adjusting a sensing distance of a video game sensor device. A lens accessory for a video game sensor device includes a first lens configured to cover an infrared light emitter of the video game sensor device, a second lens configured to cover an infrared light receiver of the video game sensor device, and a body portion coupling the first lens and the second lens together, the body portion being removably attachable to the video game sensor device, and the first lens and the second lens having a magnification for adjusting a sensing distance of the video game sensor device.

Abstract: A hand-held device, such as a remote control, has a time-limited feature, such as backlight illumination, that is caused to be activated upon the occurrence of a triggering event sensed by a triggering sensor, such as a motion sensor. The hand-held device functions to disable and/or downwardly adjust a time period during which the time-limited feature will be allowed to be active upon a future occurrence of a triggering event in response to the device determining that a predetermined number of trigger events sensed via the triggering sensor are false trigger events. The time-limited feature may be disabled by disabling the triggering sensor.

Abstract: Methods and systems are disclosed for rapid detection of cerebrospinal fluid (CSF) in a sample. In some embodiments, the methods comprise depleting a biological sample of beta-1 transferrin by contacting the sample with a sialic acid-specific lectin bound to a solid support, followed by subjecting the beta-1 transferrin-depleted sample to a lateral flow immunoassay. The methods can be used to detect CSF comprised by a sample in under one hour. Furthermore, the methods can detect CSF in a biological sample such as a plasma sample of a volume as small as about 10 ?l.

Abstract: A lens accessory for a video game sensor device and a method of adjusting a sensing distance of a video game sensor device. A lens accessory for a video game sensor device includes a first lens configured to cover an infrared light emitter of the video game sensor device, a second lens configured to cover an infrared light receiver of the video game sensor device, and a body portion coupling the first lens and the second lens together, the body portion being removably attachable to the video game sensor device, and the first lens and the second lens having a magnification for adjusting a sensing distance of the video game sensor device.

Abstract: An MWD data transmission system and method for determining and transmitting the environmental properties of the downhole borehole assembly (BHA) to surface data receivers via mud pulse telemetry, EM telemetry, or both mud pulse telemetry and EM telemetry based on one or more determined properties of the downhole environment.