Abstract: Methods for producing an enriched reference data map useful for identifying critical factors for the development of a condition of interest are disclosed. The reference data map may be used to assess the risk or likelihood of a condition of interest being realized. In the context of medicine or genetics, the methods of the invention may be used to produce a risk assessment roadmap useful for identifying elements (biomolecular constructs, biological interactions, and biological pathways) that are critical to the development of a particular disease or syndrome. The roadmap may be consulted to design treatment methods having the greatest likelihood of successfully treating or preventing the development of a disease or syndrome. Also disclosed are methods for using such a risk assessment roadmap to evaluate a specific configuration of elements for determining the changes in the configuration of elements that will result in the achievement or the avoidance of a defined condition of interest.

Abstract: The invention is directed to a probe-type imaging device useful to visualize interior surfaces, e.g., the lumen of blood vessels. Specifically, the probe-type device is particularly useful for direct tissue imaging in the presence or absence of molecular imaging agents.

Abstract: The invention is directed to a probe-type imaging device useful to visualize interior surfaces, e.g., the lumen of blood vessels. Specifically, the probe-type device is particularly useful for direct tissue imaging in the presence or absence of molecular imaging agents.

Abstract: The invention is directed to a probe-type imaging device useful to visualize interior surfaces, e.g., the lumen of blood vessels. Specifically, the probe-type device is particularly useful for direct tissue imaging in the presence or absence of molecular imaging agents.

Abstract: The present invention clarifies and contrasts stain intact biological tissue samples for microscopic analysis. A biological specimen is depigmented and then contacted with a fluorescent dye, wherein the dye stains the specimen nonspecifically. The depigmented, non-specifically stained specimen is equilibrated in a clearing solution, wherein the refractive index of the clearing solution approximates that of the specimen, thereby preparing the biological specimen for visual analysis.

Abstract: The present invention provides a method to clarify and contrast stain intact biological tissue samples for microscopic analysis. Biological specimens are prepared for visual analysis by depigmenting specimen, staining the specimen non-specifically with fluorescent dye, and equilibrating the depigmented, non-specifically stained specimen in a clearing solution, wherein the refractive index of the clearing solution approximates that of the specimen. Visual analysis of the specimen can include, for example, determination of distribution, quantity and size of foreign material in the biological specimen. Also, the morphology of tissue surrounding foreign material can be assessed.