Patents by Inventor Rick Cerione

Rick Cerione has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Labeled glutaminase proteins, isolated glutaminase protein mutants, methods of use, and kit
    Patent number: 11046945
    Abstract: The present invention relates to a labeled glutaminase (GLS) protein comprising a GLS protein and a fluorescent reporter group attached to the GLS protein, wherein the fluorescent reporter group is attached to the GLS protein within the glutaminase domain pfam04960 of GLS. The present invention also relates to isolated glutaminase protein mutants. Also disclosed is a method of screening for compounds that allosterically bind to a glutaminase protein. The present invention also relates to a method of identifying compounds that inhibit or stabilize tetramer formation of glutaminase protein. The present invention further relates to a screening kit for compounds that inhibit or stabilize tetramer formation.
    Type: Grant
    Filed: February 27, 2014
    Date of Patent: June 29, 2021
    Assignee: CORNELL UNIVERSITY
    Inventors: Clint A. Stalnecker, Jon W. Erickson, Sekar Ramachandran, Rick Cerione
  • LABELED GLUTAMINASE PROTEINS, ISOLATED GLUTAMINASE PROTEIN MUTANTS, METHODS OF USE, AND KIT
    Publication number: 20160002619
    Abstract: The present invention relates to a labeled glutaminase (GLS) protein comprising a GLS protein and a fluorescent reporter group attached to the GLS protein, wherein the fluorescent reporter group is attached to the GLS protein within the glutaminase domain pfam04960 of GLS. The present invention also relates to isolated glutaminase protein mutants. Also disclosed is a method of screening for compounds that allosterically bind to a glutaminase protein. The present invention also relates to a method of identifying compounds that inhibit or stabilize tetramer formation of glutaminase protein. The present invention further relates to a screening kit for compounds that inhibit or stabilize tetramer formation.
    Type: Application
    Filed: February 27, 2014
    Publication date: January 7, 2016
    Inventors: Clint A. STALNECKER, Jon W. ERICKSON, Sekar RAMACHANDRAN, Rick CERIONE
  • Compositions and Methods to Prevent Cell Transformation and Cancer Metastasis
    Publication number: 20140079717
    Abstract: Provided are methods for characterizing microvesicles or other membranous structures. The methods involve assaying samples for microvesicles or other membranous structures, and include in certain aspects determining the presence or absence of tissue transglutaminase (tTG) and/or cross-linked fibronection (FN). The microvesicles or other membranous structures can be separated from a sample using recombinant tTG or a derivative of it, or tTG or FN binding partners. Also provided are methods for inhibiting the transfer of cargo from microvesicles which contain tTG to one or more cells. This involves administering to the individual a tTG inhibitor, such as a cell-impermeable tTG inhibitor. Also provided are compositions which contain a population of microvesicles or other membranous structures, where the population is attached to tTG or a derivative thereof, or to tTG or an FN binding partner. Kits which contain reagents and other components for carrying out the method are also provided.
    Type: Application
    Filed: February 17, 2012
    Publication date: March 20, 2014
    Applicant: CORNELL UNIVERSITY
    Inventors: Rick Cerione, Marc Antonyak, Kristin Wilson Cerione, Bo Li