Abstract: The present disclosure relates to novel compounds for use in therapeutic treatment of a disease associated with peptidylarginine deiminases (PADs), such as peptidylarginine deiminase type 4 (PAD4). The present disclosure also relates to processes and intermediates for the preparation of such compounds, methods of using such compounds and pharmaceutical compositions comprising the compounds described herein.

Abstract: The present disclosure relates to novel compounds for use in therapeutic treatment of a disease associated with peptidylarginine deiminases (PADs), such as peptidylarginine deiminase type 4 (PAD4). The present disclosure also relates to processes and intermediates for the preparation of such compounds, methods of using such compounds and pharmaceutical compositions comprising the compounds described herein.

Abstract: The present disclosure relates to novel compounds for use in therapeutic treatment of a disease associated with peptidylarginine deiminases (PADs), such as peptidylarginine deiminase type 4 (PAD4). The present disclosure also relates to processes and intermediates for the preparation of such compounds, methods of using such compounds and pharmaceutical compositions comprising the compounds described herein.

Abstract: The present disclosure relates to novel compounds for use in therapeutic treatement of a disease associated with peptidylarginine deiminases (PADs), such as peptidylarginine deiminase type 4 (PAD4). The present disclosure also relates to processes and intermediates for the preparation of such compounds, methods of using such compounds and pharmaceutical compositions comprising the compounds described herein.

Abstract: A cabinet includes a first shelf disposed inside the cabinet at a height above waist level, the first shelf having a first retracted position and a first deployed position below and outwardly from the first retracted position; a first parallelogram linkage pivotably operably attached to a first end of the first shelf and the cabinet; a second parallelogram linkage pivotally operably attached to the cabinet and a second end of the first shelf; a first shaft having a first end operably engaged with the first parallelogram linkage, the first shaft having a second end operably engaged with the second parallelogram linkage; and a drive motor operably engaged with the first shaft to operate the first and second parallelogram linkages outwardly and downwardly to position the first shelf from the first retracted position to the first deployed position.

Abstract: A calcium silicate insulation product includes a calcium silicate hydrate matrix that is predominantly but not substantially all xonotlite, for example 51-90 weight percent xonotlite and 10-49 weight percent tobermorite. The insulation product also contains wollastonite, and may include fines of lime and silica and reinforcing carbon fibers. A method of producing the insulation product includes providing the components of the insulation as dry solids, blending the dry solids with water to form a slurry, filter pressing the slurry to form a pressed shape, and curing the pressed shape under steam pressure only until the desired proportions of xonotlite and tobermorite are achieved in the calcium silicate hydrate matrix.

Abstract: A trailer has a container with top doors having a frame and weatherproof thermoplastic inserts. Sealing flaps are provided at edges of the top doors to make sealing contact with sidewall top rails or top edges of end walls and tailgate. The top doors have angled extensions with grooves for ball gaskets to overlap in hand-in-hand fashion to form a reliable seal where the top doors come together. The system provides a weatherproof means to enclose the container to prevent or deter entry of water.

Abstract: A slat for a conveyor where the conveyor has one or more curves. The slat has landing gears carrying wheels set apart from the slat, and the wheels are capable of engaging a surface distinctive from the landing gears.

Abstract: According to one aspect, a hybrid high temperature thermal insulation includes a mix of inorganic granules. The granular mix includes at least 70 weight percent porous inorganic granules in the form of expanded perlite, and at most 30 weight percent second porous inorganic granules other than expanded perlite. The hybrid insulation also includes a binder. In example formulations, the second porous inorganic particles may be made from crushed aerogel, from fumed silica, from precipitated silica, or from other substances. The hybrid insulation may be formed into preferred shapes, for example a board shape or a semi-cylindrical shape configured to fit over a round tube of a predetermined diameter.

Abstract: A trailer has a container with top doors having a frame and weatherproof thermoplastic inserts. Sealing flaps are provided at edges of the top doors to make sealing contact with sidewall top rails or top edges of end walls and tailgate. The top doors have angled extensions with grooves for ball gaskets to overlap in hand-in-hand fashion to form a reliable seal where the top doors come together. The system provides a weatherproof means to enclose the container to prevent or deter entry of water.

Abstract: Disclosed is an apparatus that includes an electric power source that powers a Marx generator that is electrically coupled to a cathode emitter that is configured to discharge electrical potential into the earth. The apparatus also includes a load resistor that is coupled between the output of the Marx generator and either a relative ground or the input to the Marx generator.

Abstract: A trailer has a container with top doors having a frame and weatherproof thermoplastic inserts. Sealing flaps are provided at edges of the top doors to make sealing contact with sidewall top rails or top edges of end walls and tailgate. The top doors have angled extensions with grooves for ball gaskets to overlap in hand-in-hand fashion to form a reliable seal where the top doors come together. The system provides a weatherproof means to enclose the container to prevent or deter entry of water.

Abstract: A protective rail for a trailer is formed of an extension or ridge projecting outwardly from a wall of the trailer and extending along at least a part of a length of the wall. The protective rail is provided with tie-down anchors for coupling with tie-downs having couplers such as rings, eyes, or loops. The anchors may tongues formed in the protective rail when the protective rail is cut-out at selected locations along the protective rail. The anchors may be sized and shaped such that the surrounding portion of the protective rail prevents or tends to prevent other trailers or objects contacting the protective rail from damaging or becoming caught on the anchors.

Abstract: A trailer has a container with top doors having a frame and weatherproof thermoplastic inserts. Sealing flaps are provided at edges of the top doors to make sealing contact with sidewall top rails or top edges of end walls and tailgate. The top doors have angled extensions with grooves for ball gaskets to overlap in hand-in-hand fashion to form a reliable seal where the top doors come together. The system provides a weatherproof means to enclose the container to prevent or deter entry of water.

Abstract: A cabinet includes a first shelf disposed inside the cabinet at a height above waist level, the first shelf having a retracted position and a deployed position below and outwardly from the retracted position. First and second pivot arms are pivotally operably attached to the first end the first shelf and to the cabinet, the first and second pivot arms forming a first parallelogram. Third and fourth pivot arms are pivotally operably attached a second end of the first shelf and to the cabinet below the first shelf, the third and fourth pivot arms forming a second parallelogram. A first drive motor operably is operably to one of the first and second pivot arms and the third and fourth pivot arms to swing the first and the second parallelograms outwardly and downwardly from the cabinet to position the first shelf from the retracted position to the deployed position.

Abstract: This application relates to chemical compounds which may act as inhibitors of, or which may otherwise modulate the activity of, a bromodomain-containing protein, including bromodomain-containing protein 4 (BRD4), and to compositions and formulations containing such compounds, and methods of using and making such compounds. Compounds include compounds of Formula (I) wherein R1a, R1b, R2a, R2b, R3, R4a, R4b, and R5 are described herein.

Abstract: A slat for a conveyor that has one or more curves.

Abstract: Disclosed is an apparatus that includes an electric power source that powers a Marx generator that is electrically coupled to a cathode emitter that is configured to discharge electrical potential into the earth. The apparatus also includes a load resistor that is coupled between the output of the Marx generator and either a relative ground or the input to the Marx generator.