Patents by Inventor Rick PAULS

Rick PAULS has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DOSAGE FORMS OF TISSUE KALLIKREIN 1
    Publication number: 20240238389
    Abstract: Provided are dosage forms of one or more tissue kallikrein-1 (KLK1) polypeptides which have a total KLK1 polypeptide dosage of about 0.1 ?g/kg to about 10.0 ?g/kg, including subcutaneous and intravenous dosage forms. Also provided are related devices and methods of use thereof, for example, for treating ischemic and hemorrhagic conditions.
    Type: Application
    Filed: November 3, 2023
    Publication date: July 18, 2024
    Inventors: Rick PAULS, Todd VERDOORN
  • ULINASTATIN POLYPEPTIDES
    Publication number: 20240002472
    Abstract: Provided are ulinastatin glycoforms, ulinastatin fusion polypeptides, and related compositions, mixtures, and methods of use, including methods of recombinantly producing ulinastatin polypeptides and treating diseases.
    Type: Application
    Filed: June 21, 2023
    Publication date: January 4, 2024
    Inventors: Rick PAULS, Todd VERDOORN, Karl Frank JOHNSON, Gregory Thomas BLECK
  • TISSUE KALLIKREIN-1 FOR TREATING CHRONIC KIDNEY DISEASE
    Publication number: 20230414727
    Abstract: Provided are methods of using human tissue kallikrein-1 (KLK1) to treat chronic kidney disease (CKD) in patients having salt-sensitive hypertension and low KLK1 levels, including methods of identifying and treating optimal sub-populations of CKD patients based on selected genotypes and/or phenotypes.
    Type: Application
    Filed: April 5, 2023
    Publication date: December 28, 2023
    Inventors: Rick PAULS, David Wambeke, Nick Paulson
  • ULINASTATIN POLYPEPTIDES FOR TREATING DISEASES
    Publication number: 20220242932
    Abstract: Provided are methods and compositions comprising ulinastatin polypeptides for treating diseases associated with elevated neutrophil elastase (NE), including NE-associated lung and skin diseases.
    Type: Application
    Filed: January 27, 2022
    Publication date: August 4, 2022
    Inventors: Rick PAULS, David WAMBEKE, Sydney GILMAN
  • ULINASTATIN POLYPEPTIDES
    Publication number: 20210277090
    Abstract: Provided are ulinastatin glycoforms, ulinastatin fusion polypeptides, and related compositions, mixtures, and methods of use, including methods of recombinantly producing ulinastatin polypeptides and treating diseases.
    Type: Application
    Filed: March 5, 2021
    Publication date: September 9, 2021
    Inventors: Rick PAULS, Todd VERDOORN, Karl Frank JOHNSON, Gregory Thomas BLECK
  • DOSAGE FORMS OF TISSUE KALLIKREIN 1
    Publication number: 20210138045
    Abstract: Provided are dosage forms of one or more tissue kallikrein-1 (KLK1) polypeptides which have a total KLK1 polypeptide dosage of about 0.1 ?g/kg to about 10.0 ?g/kg, including subcutaneous and intravenous dosage forms. Also provided are related devices and methods of use thereof, for example, for treating ischemic and hemorrhagic conditions.
    Type: Application
    Filed: March 9, 2018
    Publication date: May 13, 2021
    Inventors: Rick PAULS, Todd VERDOORN