Abstract: A circuit card apparatus includes a circuit card and a heat dissipation device in thermal contact with the circuit card at a thermal interface to conduct heat from the circuit card. An adjustable spacing element is adjustably coupled to one of the heat dissipation device and the circuit card. The adjustable spacing element is configured to be adjusted to set a minimum spaced distance between a portion of the circuit card and a portion of the heat dissipation device. A locking element is coupled to the adjustable spacing element to lock the minimum spaced distance. In further examples, methods of manufacturing a circuit card apparatus include the step of adjusting a spacing element to set the spaced distance as a minimum spaced distance between a portion of a heat dissipation device and a portion of a circuit card. The method further comprises the step of locking the minimum spaced distance.

Abstract: The present invention is directed to improved processes for making antibody conjugates with effector moieties, wherein the conjugation reaction is carried out in a solution comprising an alcohol. The alcohol solvated conjugation reaction may be conducted at room temperature and/or in a single-pot enclosed system that minimizes the safety risks of conjugating highly cytotoxic agents. The disclosed conjugation process is capable of producing high monomer content, commercial scale quantities of antibody conjugates in a single batch.