Abstract: The present disclosure provides novel engineered target-biomolecule-producing bacterial strains and methods of producing the same. To engineer bacterial strains capable of producing substantial levels of a target biomolecule, the methods may implement the use of metabolic modeling and machine learning methods. The methods and bacterial strains produced by the methods may be implemented in further optimizing a biosynthetic pathway, e.g., to improve the production of a target biomolecule of interest, e.g., an amino acid, such as threonine.

Abstract: A system can include one or more processors configured to identify a candidate molecule, provide the candidate molecule as an input to a simulation, operate the simulation, monitor at least one parameter of the simulation, modify the candidate molecule based on the at least one parameter, and output the modified candidate molecule responsive to a convergence condition being satisfied.

Abstract: Systems and methods are disclosed for managing and preventing liability issues relating to regulating usage and control of controlled substances. Systems include various means of administering controlled substances that are designed to prevent misuse and injury. Methods include various means of controlling dosage and preventing usage by minors or unapproved consumers. Methods include transparent labeling wherein all ingredients are clearly labeled and described as well as any potential health risks associated with use on the product packaging. Methods also include product marking tracing scenarios.

Abstract: Systems and methods are disclosed for managing and preventing liability issues relating to regulating usage and control of controlled substances. Systems include various means of administering controlled substances that are designed to prevent misuse and injury. Methods include various means of controlling dosage and preventing usage by minors or unapproved consumers. Methods include transparent labeling wherein all ingredients are clearly labeled and described as well as any potential health risks associated with use on the product packaging. Methods also include product marking tracing scenarios.

Abstract: A soft-sided insulated container assembly is made of a flexible wall structure that is movable between a collapsed position and a deployed position. In one variation of the deployed position it resembles a tote-bag; in another variation of folding the deployed position corresponds to a generally box-like shape. The container includes a self-inflating wall structure that has an inner layer or skin, an outer layer or skin, and a resilient, open-cell insulating layer trapped between the two skins. A valve governs the ability to take in or to expel air. The outer layer may be thicker and more robust that the inner layer, the better to resist abrasion or punctures. The inner layer may be reflective. There may be a removable internal liner. That liner may be transparent.

Abstract: An optical network system, including multiple nodes, an optical switch, and a switch controller, is configured to achieve communication in the optical domain. Each node is configured to receive both high frequency and low frequency inputs, generally utilized for handling data and addressing information, respectively. The two types of information are combined to create an amplitude modulated optical signal. Subsequently, the two types of information are separated by examining the optical power average of the signal being transmitted. Using one portion of the signal for addressing information, the switch controller can perform necessary routing and arbitration functions. Appropriate communications can then be sent back to the nodes and the optical switch to achieve the necessary configuration. The protocol utilized allows for subsequent arbitration and data transmission cycles, allowing the system and switch controller to configure transmission paths and arbitrate any communication issues.

Abstract: One embodiment includes a connector for an optical pathway. The connector includes a body formed, at least in part, with a temperature sensitive material having one or more light transmission characteristics that change based upon the temperature of the material.

Abstract: The present disclosure is directed to an optical apparatus suitable for coupling to an optical network. The optical apparatus is adapted to transmit multiplexed optical signals on the optical network and/or de-multiplex optical transmissions from the network. The optical apparatus includes an optical waveguide and an optoelectronic device. The optical waveguide has a set of diffractive elements in the form of a scribed volume hologram, which provides an optical transfer function. The optical waveguide also includes a first optical port and a second optical port. The second optical port is adapted to be optically coupled to the optical network. The optoelectronic device includes a plurality of optical portions. The optoelectronic device is adapted to convert optical signals at the optical portions into electric signals and/or convert electric signals into optical signals at the optical portions.

Abstract: Systems and apparatuses are provided that include a number of cameras. One embodiment includes a surveillance camera. The embodiment includes a camera having a lens with a first field of view. The camera can be mounted to an imaging circuit board having an imaging circuit provided thereon for converting image data from the lens into a digital field of view.

Abstract: The present disclosure is directed to an optical device including a circuit board, an optical network and a lens kit. The circuit board has a mounting surface, and the optical fiber network is coupled to the circuit board opposite the mounting surface. The optical network includes two or more optical waveguides arranged in layers. A via extends through the mounting surface and into the optical network. The lens kit includes at least two lens pucks. At least one lens puck has a reflective element. The lens pucks are arranged to correspond with at least some of the optical waveguides. The lens kit is adapted to be inserted within the via and to reflect light traveling along an axis of the via into the optical network. The present disclosure is also directed to the lens kit and methods of making the lens kit and the optical device.

Abstract: An apparatus and method for coupling and decoupling optical leads while preventing twists or kinks in the optical leas as well as back reflections with the apparatus including an a rotatable optical coupler and a non-rotatable optical coupler.

Abstract: Optical routers or optical interconnection devices that include an optical coupling method and optical coupling apparatus wherein a plurality of layers that contain optical devices that require optical coupling can be optically coupled by inserting optical coupling elements therein to transfer a light signal from one location on one layer to another location on a different layer. The optical coupling elements can include various light directing members such as reflectors, beam splitters/combiners or other components that can act on a light signal to modify, or control the light signal in a desired manner. In addition, an optical coupling elements can be transparent to the light signal so as not affect the direction or the integrity of the light signal as it passes through the optical coupling element.

Abstract: A communications arrangement that provides multiple levels of security is described. In one embodiment, a plurality of seedable code generators is configured to generate different sets of codes. A plurality of CDMA encoders are respectively coupled to the code generators, and each encodes input data using the set of codes generated by the coupled code generator. A plurality of CDMA decoders are similarly arranged for decoding input data. A node controller provides respective input seeds to the code generators and provides respective sets of codes from the code generators to paired encoders and decoders. An interconnect combines encoded data from the encoders into an output signal and transmits the output signal. An input signal received by the interconnect interface is provided to each decoder.

Abstract: An optical connector having alignment members for aligning with a connector on two mutually perpendicular axis with the optical connector including a displaceable block carrying optical fibers therein that is spatially positionable along a third axis to provide optical communication through the optical connector even though the optical connector may not have continuous optical fibers extending therethrough.

Abstract: An apparatus for and method of producing a highly accurate and easily recalibratable delay line using only digital components. A serial string of digital gates or buffers is coupled together to permit an input signal to cascade through all of the gates or buffers. The length of time for the signal to cascade is determined by the average propagation delay of the buffers and the number of buffers in the serial string. Taps at the outputs of the buffers permit selection of the desired delay by selecting the output from less than all of the buffers in the string. Calibration is accomplished by passing a calibration pulse of predetermined pulse width through the delay string of buffers. A calibration register records the buffer position of the leading edge of the calibration pulse at the time the trailing edge of the calibration pulse enters the string. The number of buffers thus identified provides a delay equal to the length of the calibration pulse under the current ambient conditions.

Abstract: An apparatus and method for transferring data messages between a sending station and a receiving station through a plurality of switches in each stage and has a plurality of inputs and outputs. Each output of each switch is connected to one of the inputs on each switch in the next succeeding stage of the interconnect device. The sending station or terminal selects a plurality of routing messages, one routing signal for each stage of the MIN, and also sends a data message or signal to a selected receiving terminal. Each routing message is sacrificial and thus ends at the stage of the MIN where it actually operates on a switch. After all routing messages are sent, one for each stage of the MIN, a path exists to the receiving station and the data message or signal is transferred.

Abstract: An apparatus and method for transferring data messages between a sending station and a receiving station through a photonic multi-stage interconnect network (MIN). The MIN has a plurality of switches in each stage and has a plurality of inputs and outputs. Each output of each switch is connected to one of the inputs on each switch in the next succeeding stage of the interconnect device. The sending station or terminal selects a plurality of routing messages, one routing signal for each stage of the MIN, and also sends a data message or signal to a selected receiving terminal. Each routing message is sacrificial and thus ends at the stage of the MIN where it actually operates on a switch. After all routing messages are sent, one for each stage of the MIN, a path exists to the receiving station and the data message or signal is transferred.