Patents by Inventor Rick VELTER

Rick VELTER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Determination of JAK-STAT3 pathway activity using unique combination of target genes
    Patent number: 12125561
    Abstract: A bioinformatics process which provides an improved means to detect a JAK-STAT3 cellular signaling pathway in a subject, such as a human, based on the expression levels of at least three unique target genes of the JAK-STAT3 cellular signaling pathway measured in a sample. The invention includes an apparatus comprising a digital processor configured to perform such a method, a non-transitory storage medium storing instructions that are executable by a digital processing device to perform such a method, and a computer program comprising program code means for causing a digital processing device to perform such a method. Kits are also provided for measuring expression levels of unique sets of JAK-STAT3 cellular signaling pathway target genes.
    Type: Grant
    Filed: September 27, 2018
    Date of Patent: October 22, 2024
    Assignee: InnoSIGN B.V.
    Inventors: Meng Dou, Wilhelmus Franciscus Johannes Verhaegh, Anja Van De Stolpe, Rick Velter
  • Determination of JAK-STAT1/2 pathway activity using unique combination of target genes
    Patent number: 11649488
    Abstract: A bioinformatics process which provides an improved means to detect a JAK-STAT1/2 cellular signaling pathway in a subject, such as a human, based on the expression levels of at least three unique target genes of the JAK-STAT1/2 cellular signaling pathway measured in a sample. The invention includes an apparatus comprising a digital processor configured to perform such a method, a non-transitory storage medium storing instructions that are executable by a digital processing device to perform such a method, and a computer program comprising program code means for causing a digital processing device to perform such a method. Kits are also provided for measuring expression levels of unique sets of JAK-STAT1/2 cellular signaling pathway target genes.
    Type: Grant
    Filed: September 27, 2018
    Date of Patent: May 16, 2023
    Assignee: InnoSIGN B.V.
    Inventors: Wilhelmus Franciscus Johannes Verhaegh, Meng Dou, Anja Van De Stolpe, Rick Velter
  • METHOD TO DISTINGUISH TUMOR SUPRESSIVE FOXO ACTIVITY FROM OXIDATIVE STRESS
    Publication number: 20190376142
    Abstract: The present invention relates to certain target genes of the FOXO transcription factor family, which are markers for an oxidative stress state and can be used for inferring an oxidative stress state of a FOXO transcription factor element in the body of a medical subject. The invention further relates to methods for inferring an oxidative stress state of a FOXO transcription element and for inferring the activity of the FOXO/PI3K cellular signalling pathway based on expression levels of the target genes as well as products to perform the methods.
    Type: Application
    Filed: November 24, 2017
    Publication date: December 12, 2019
    Applicant: KONINKLIJKE PHILIPS N.V.
    Inventors: Anja VAN DE STOLPE, Rick VELTER, Wilhelmus Franciscus Johannes VERHAEGH, Hendrik Jan VAN OOIJEN, Martijn Theodorus Lambert AKSE
  • DETERMINATION OF JAK-STAT3 PATHWAY ACTIVITY USING UNIQUE COMBINATION OF TARGET GENES
    Publication number: 20190102510
    Abstract: A bioinformatics process which provides an improved means to detect a JAK-STAT3 cellular signaling pathway in a subject, such as a human, based on the expression levels of at least three unique target genes of the JAK-STAT3 cellular signaling pathway measured in a sample. The invention includes an apparatus comprising a digital processor configured to perform such a method, a non-transitory storage medium storing instructions that are executable by a digital processing device to perform such a method, and a computer program comprising program code means for causing a digital processing device to perform such a method. Kits are also provided for measuring expression levels of unique sets of JAK-STAT3 cellular signaling pathway target genes.
    Type: Application
    Filed: September 27, 2018
    Publication date: April 4, 2019
    Inventors: Meng DOU, Wilhelmus Franciscus Johannes VERHAEGH, Anja VAN DE STOLPE, Rick VELTER
  • DETERMINATION OF JAK-STAT1/2 PATHWAY ACTIVITY USING UNIQUE COMBINATION OF TARGET GENES
    Publication number: 20190100795
    Abstract: A bioinformatics process which provides an improved means to detect a JAK-STAT1/2 cellular signaling pathway in a subject, such as a human, based on the expression levels of at least three unique target genes of the JAK-STAT1/2 cellular signaling pathway measured in a sample. The invention includes an apparatus comprising a digital processor configured to perform such a method, a non-transitory storage medium storing instructions that are executable by a digital processing device to perform such a method, and a computer program comprising program code means for causing a digital processing device to perform such a method. Kits are also provided for measuring expression levels of unique sets of JAK-STAT1/2 cellular signaling pathway target genes.
    Type: Application
    Filed: September 27, 2018
    Publication date: April 4, 2019
    Inventors: Wilhelmus Franciscus Johannes VERHAEGH, Meng DOU, Anja VAN DE STOLPE, Rick VELTER