Patents by Inventor Rick Wagner

Rick Wagner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for identifying modulators of ion channels
    Patent number: 11016100
    Abstract: The invention provides methods for identifying modulators of ion channels without the use of recombinant cell lines over-expressing the ion channel proteins or the use of detection labels.
    Type: Grant
    Filed: September 9, 2015
    Date of Patent: May 25, 2021
    Assignee: X-BODY, INC.
    Inventors: Lance G. Laing, Rick Wagner, Rafael Fernandez, Alexander Yuzhakov
  • Methods for Identifying Modulators of Ion Channels
    Publication number: 20160069901
    Abstract: The invention provides methods for identifying modulators of ion channels without the use of recombinant cell lines over-expressing the ion channel proteins or the use of detection labels.
    Type: Application
    Filed: September 9, 2015
    Publication date: March 10, 2016
    Inventors: Lance G. Laing, Rick Wagner, Rafael Fernandez, Alexander Yuzhakov
  • Method for determining ion channel modulating properties of a test reagent
    Patent number: 9134307
    Abstract: The invention provides methods for identifying modulators of ion channels without the use of recombinant cell lines over-expressing the ion channel proteins or the use of detection labels.
    Type: Grant
    Filed: December 15, 2008
    Date of Patent: September 15, 2015
    Assignee: X-Body, Inc.
    Inventors: Lance G. Laing, Rick Wagner, Rafael Fernandez, Alexander Yuzhakov
  • High resolution label free analysis of cellular properties
    Patent number: 8372592
    Abstract: The invention provides methods of detecting a change in cell growth patterns.
    Type: Grant
    Filed: September 22, 2011
    Date of Patent: February 12, 2013
    Assignee: X-Body, Inc.
    Inventors: Lance G. Laing, Rafael Fernandez, Rick Wagner
  • Methods of detection of changes in cells
    Patent number: 8298780
    Abstract: Methods are provided to detect changes in cells without the use of detection labels.
    Type: Grant
    Filed: December 15, 2008
    Date of Patent: October 30, 2012
    Assignee: X-Body, Inc.
    Inventors: Rick Wagner, Rafael Fernandez, Brian T. Cunningham, Lance Laing
  • High resolution label free analysis of cellular properties
    Patent number: 8257936
    Abstract: The invention provides methods of detecting a change in cell growth patterns.
    Type: Grant
    Filed: April 9, 2009
    Date of Patent: September 4, 2012
    Assignee: X-Body Inc.
    Inventors: Lance G. Laing, Rafael Fernandez, Rick Wagner
  • High Resolution Label Free Analysis of Cellular Properties
    Publication number: 20120040866
    Abstract: The invention provides methods of detecting a change in cell growth patterns.
    Type: Application
    Filed: September 22, 2011
    Publication date: February 16, 2012
    Inventors: Lance G. Laing, Rafael Fernandez, Rick Wagner
  • Use of Induced Pluripotent Cells and other Cells for Screening Compound Libraries
    Publication number: 20110237535
    Abstract: The invention provides methods for screening test compounds or toxins for effects on cells. The invention also provides methods for determining frequency, amplitude and kinetic profiles of cells.
    Type: Application
    Filed: March 28, 2011
    Publication date: September 29, 2011
    Inventors: Alexander Yuzhakov, Eric Sandberg, Steven Shamah, Rick Wagner
  • Detection of Changes in Cell Populations and Mixed Cell Populations
    Publication number: 20100291575
    Abstract: The invention provides methods of label-free detection of changes in cell populations and mixed cell populations.
    Type: Application
    Filed: May 17, 2010
    Publication date: November 18, 2010
    Inventors: Steven Shamah, Lance G. Laing, Alexander Yuzhakov, Rick Wagner, Marla Abodeely, Bennett Rockney, Stephen C. Schulz, Zinkal Padalia, Michael Getman, Eric Sandberg
  • High Resolution Label Free Analysis of Cellular Properties
    Publication number: 20090305304
    Abstract: The invention provides methods of detecting a change in cell growth patterns.
    Type: Application
    Filed: April 9, 2009
    Publication date: December 10, 2009
    Inventors: Lance G. Laing, Rafael Fernandez, Rick Wagner
  • Methods for Identifying Modulators of Ion Channels
    Publication number: 20090137422
    Abstract: The invention provides methods for identifying modulators of ion channels without the use of recombinant cell lines over-expressing the ion channel proteins or the use of detection labels.
    Type: Application
    Filed: December 15, 2008
    Publication date: May 28, 2009
    Inventors: Lance G. Laing, Rick Wagner, Rafael Fernandez, Alexander Yuzakov
  • Tripartite RNAi constructs
    Publication number: 20090131360
    Abstract: The present invention provides compositions and methods for inhibiting expression of a target gene in a cell. The process comprises introduction of double-stranded tripartite RNAi constructs into the cells and reducing the expression of the corresponding messenger RNA in the cells. The constructs, which may be packaged in or delivered as sequestered RNAi constructs, differ from the canonical siRNA in that they comprise a tripartite structure which follows the general formula of having (1) an RNAi core (either native or abbreviated), (2) one or more terminal moieties attached to the RNAi core and optionally (3) a linker between the RNAi core and the terminal moiety.
    Type: Application
    Filed: October 2, 2008
    Publication date: May 21, 2009
    Inventors: Tod M. Woolf, Pamela A. Pavco, William Salomon, Dmitry Samarsky, Nassim Usman, Rick Wagner
  • Methods of Detection of Changes in Cells
    Publication number: 20090130703
    Abstract: Methods are provided to detect changes in cells without the use of detection labels.
    Type: Application
    Filed: December 15, 2008
    Publication date: May 21, 2009
    Applicant: SRU Biosystems, Inc.
    Inventors: Rick Wagner, Rafael Fernandez, Brian T. Cunningham, Lance Laing
  • Error recovery for input/output operations
    Patent number: 7478265
    Abstract: Method, system, and apparatus for executing input/output operations. The method including selecting a level of error recovery for input/output operations, receiving a request to execute the input/output operation, attempting the input/output operation, and when the input/output operation fails, performing the level of error recovery specified. The selection of the error recovery level may be done by a user, or embedded within the input/output request itself.
    Type: Grant
    Filed: October 14, 2004
    Date of Patent: January 13, 2009
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventors: Frederick Earl Knight, Susan Rundbaken, Rick Wagner
  • Method for Employing a Biosensor to Detect Small Molecules ("Fragments") that Bind Directly to Immobilized Protein Targets
    Publication number: 20080299673
    Abstract: The invention provides method of detecting interactions of small molecules with target molecules.
    Type: Application
    Filed: April 19, 2008
    Publication date: December 4, 2008
    Inventors: Rick Wagner, Lance Laing
  • Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines
    Patent number: 7057027
    Abstract: Novel oligomers are disclosed which have enhanced ability with respect to forming duplexes or triplexes compared with oligomers containing only conventional bases. The oligomers contain the bases 5-(1-propynyl)uracil, 5-(1-propynyl)cytosine or related analogs. The oligomers of the invention are capable of (i) forming triplexes with various target sequences such as virus or oncogene sequences by coupling into the major groove of a target DNA duplex at physiological pH or (ii) forming duplexes by binding to single-stranded DNA or to RNA encoded by target genes. The oligomers of the invention can be incorporated into pharmaceutically acceptable carriers and can be constructed to have any desired sequence, provided the sequence normally includes one or more bases that is replaced with the analogs of the invention.
    Type: Grant
    Filed: December 8, 2003
    Date of Patent: June 6, 2006
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Brian Froehler, Rick Wagner, Mark Mattencci, Robert J. Jones, Arnold J. Gutierrez, Jeff Pudlo
  • Error recovery for input/output operations
    Publication number: 20060085665
    Abstract: Method, system, and apparatus for executing input/output operations. The method including selecting a level of error recovery for input/output operations, receiving a request to execute the input/ output operation, attempting the input/output operation, and when the input/output operation fails, performing the level of error recovery specified. The selection of the error recovery level may be done by a user, or embedded within the input/output request itself.
    Type: Application
    Filed: October 14, 2004
    Publication date: April 20, 2006
    Inventors: Frederick Knight, Susan Rundbaken, Rick Wagner
  • Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines
    Patent number: 6962783
    Abstract: Novel oligomers are disclosed which have enhanced ability with respect to forming duplexes or triplexes compared with oligomers containing only conventional bases. The oligomers contain the bases 5-(1-propynyl)uracil, 5-(1-propynyl)cytosine or related analogs. The oligomers of the invention are capable of (i) forming triplexes with various target sequences such as virus or oncogene sequences by coupling into the major groove of a target DNA duplex at physiological pH or (ii) forming duplexes by binding to single-stranded DNA or to RNA encoded by target genes. The oligomers of the invention can be incorporated into pharmaceutically acceptable carriers and can be constructed to have any desired sequence, provided the sequence normally includes one or more bases that is replaced with the analogs of the invention.
    Type: Grant
    Filed: December 18, 2001
    Date of Patent: November 8, 2005
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Brian Froehler, Rick Wagner, Mark Matteucci, Robert J. Jones, Arnold J. Gutierrez, Jeff Pudlo
  • Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines
    Patent number: 6875593
    Abstract: Novel oligomers are disclosed which have enhanced ability with respect to forming duplexes or triplexes compared with oligomers containing only conventional bases. The oligomers contain the bases 5-(1-propynyl)uracil, 5-(1-propynyl)cytosine or related analogs. The oligomers of the invention are capable of (i) forming triplexes with various target sequences such as virus or oncogene sequences by coupling into the major groove of a target DNA duplex at physiological pH or (ii) forming duplexes by binding to single-stranded DNA or to RNA encoded by target genes. The oligomers of the invention can be incorporated into pharmaceutically acceptable carriers and can be constructed to have any desired sequence, provided the sequence normally includes one or more bases that is replaced with the analogs of the invention.
    Type: Grant
    Filed: November 14, 2002
    Date of Patent: April 5, 2005
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Brian Froehler, Rick Wagner, Mark Matteucci, Robert J. Jones, Arnold J. Gutierrez, Jeff Pudlo
  • ENHANCED TRIPLE-HELIX AND DOUBLE-HELIX FORMATION WITH OLIGOMERS CONTAINING MODIFIED PYRIMIDINES
    Publication number: 20040265802
    Abstract: Novel oligomers are disclosed which have enhanced ability with respect to forming duplexes or triplexes compared with oligomers containing only conventional bases. The oligomers contain the bases 5-(1-propynyl)uracil, 5-(1-propynyl)cytosine or related analogs. The oligomers of the invention are capable of (i) forming triplexes with various target sequences such as virus or oncogene sequences by coupling into the major groove of a target DNA duplex at physiological pH or (ii) forming duplexes by binding to single-stranded DNA or to RNA encoded by target genes. The oligomers of the invention can be incorporated into pharmaceutically acceptable carriers and can be constructed to have any desired sequence, provided the sequence normally includes one or more bases that is replaced with the analogs of the invention.
    Type: Application
    Filed: November 14, 2002
    Publication date: December 30, 2004
    Inventors: Brian Froehler, Rick Wagner, Mark Matteucci, Robert J. Jones, Arnold J. Gutierrez, Jeff Pudlo