Abstract: Geldanamycin derivatives that block the uPA-plasmin network and inhibit growth and invasion by glioblastoma cells and other tumors at femtomolar concentrations are potentially highly active anti-cancer drugs. GA and various 17-amino-17-demethoxygelddanamycin derivatives are disclosed that block HGF/SF-mediated Met tyrosine kinase receptor-dependent uPA activation at fM levels. Other ansamycins (macbecins I and II), GA derivatives, and radicicol required concentrations several logs higher (?nM) to achieve such inhibition. The inhibitory activity of tested compounds was discordant with the known ability of drugs of this class to bind to hsp90, indicating the existence of a novel target(s) for HGF/SF-mediated events in tumor development. Methods of using such compounds to inhibit cancer cell activities and to treat tumors are disclosed.

Abstract: A method of recycling or destroying the components of viscous oil well drilling mud and saltwater which includes reducing the mud to an aqueous slurry; separating and collecting the useable hydrocarbons from the slurry by evaporation or chemical action; injecting deleterious substances including saltwater into an environmentally approved injection well; and or forming fertilizer pellets from remaining dehydrated solids.