Patents by Inventor Ricky M. S. WONG

Ricky M. S. WONG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Imaging beta-amyloid peptides aggregation
    Patent number: 9795694
    Abstract: The present invention is in the field of pharmaceuticals and chemical industries. In particular, one aspect of the present invention relates to methods for labeling, imaging and detecting the beta-amyloid (A?) peptides, oligomers, and fibrils in vitro and in vivo via magnetic resonance and florescence imaging by using modified carbazole-based fluorophores. A further aspect of the present invention relates to a method of reducing and preventing aggregation of beta-amyloid peptides for Alzheimer's disease (AD) as well as of treating and/or preventing Alzheimer's disease by using the modified carbazole-based fluorophore. The modified carbazole-based fluorophore according to an embodiment of the present invention is prepared by conjugating a carbazole-based fluorophore with magnetic nanoparticles to form a conjugate which is permeable to blood brain barrier of a subject being introduced therewith.
    Type: Grant
    Filed: February 21, 2016
    Date of Patent: October 24, 2017
    Assignee: Hong Kong Baptist University
    Inventors: Yinhui Li, Di Xu, See-Lok Ho, Chung-Yan Poon, Hei-Nga Chan, Hung Wing Li, Ricky M. S. Wong
  • Imaging Beta-Amyloid Peptides Aggregation
    Publication number: 20160243264
    Abstract: The present invention is in the field of pharmaceuticals and chemical industries. In particular, one aspect of the present invention relates to methods for labeling, imaging and detecting the beta-amyloid (A?) peptides, oligomers, and fibrils in vitro and in vivo via magnetic resonance and florescence imaging by using modified carbazole-based fluorophores. A further aspect of the present invention relates to a method of reducing and preventing aggregation of beta-amyloid peptides for Alzheimer's disease (AD) as well as of treating and/or preventing Alzheimer's disease by using the modified carbazole-based fluorophore. The modified carbazole-based fluorophore according to an embodiment of the present invention is prepared by conjugating a carbazole-based fluorophore with magnetic nanoparticles to form a conjugate which is permeable to blood brain barrier of a subject being introduced therewith.
    Type: Application
    Filed: February 21, 2016
    Publication date: August 25, 2016
    Inventors: Yinhui LI, Di XU, See-Lok HO, Chung-Yan POON, Hei-Nga CHAN, Hung Wing LI, Ricky M. S. WONG
  • Imaging beta-amyloid peptides and inhibition of beta-amyloid peptide aggregation
    Patent number: 9403794
    Abstract: The present invention is in the field of pharmaceuticals and chemical industries. In particular, the present invention relates to methods for labeling, imaging and detecting the beta-amyloid (A?) peptides, oligomers, and fibrils in vitro by using carbazole-based fluorophores. A further aspect of the present invention relates to a method of reducing and preventing aggregation of beta-amyloid peptides for Alzheimer's disease (AD) as well as of treating and/or preventing Alzheimer's disease by using carbazole-based fluorophores.
    Type: Grant
    Filed: March 31, 2014
    Date of Patent: August 2, 2016
    Assignee: HONG KONG BAPTIST UNIVERSITY
    Inventors: Lei Guo, Di Xu, See-Lok Ho, Chung-Yan Poon, Olivia T. W. Ng, Hung Wing Li, Ken K. L. Yung, Daniel W. J. Kwong, Ricky M. S. Wong
  • Imaging beta-amyloid peptides and inhibition of beta-amyloid peptide aggregation
    Patent number: 9255933
    Abstract: The present invention is in the field of pharmaceuticals and chemical industries. In particular, the present invention relates to methods for labeling, imaging and detecting the beta-amyloid (A?) peptides, oligomers, and fibrils in vitro by using carbazole-based fluorophores. A further aspect of the present invention relates to a method of reducing and preventing aggregation of beta-amyloid peptides for Alzheimer's disease (AD) as well as of treating and/or preventing Alzheimer's disease by using carbazole-based fluorophores.
    Type: Grant
    Filed: March 31, 2014
    Date of Patent: February 9, 2016
    Assignee: HONG KONG BAPTIST UNIVERSITY
    Inventors: Lei Guo, Di Xu, See-Lok Ho, Chung-Yan Poon, Olivia T. W. Ng, Hung Wing Li, Ken K. L. Yung, Daniel W. J. Kwong, Ricky M. S. Wong
  • Imaging beta-amyloid peptides and inhibition of beta-amyloid peptide aggregation
    Patent number: 9156814
    Abstract: The present invention relates to methods of detecting and monitoring aggregation of beta-amyloid peptides which are associated with neurodegenerative diseases as well as treating and/or preventing the neurodegenerative diseases by using carbazole-based fluorophores. In particular, the present invention provides methods for labeling and imaging the beta-amyloid (A?) peptides, oligomers, and fibrils in vitro and/or in vivo, as well as treating and/or preventing Alzheimer's disease by using the carbazole-based fluorophores of the present invention.
    Type: Grant
    Filed: April 13, 2012
    Date of Patent: October 13, 2015
    Assignee: HONG KONG BAPTIST UNIVERSITY
    Inventors: Wanggui Yang, Yi Wong, Olivia T. W. Ng, Hung Wing Li, Ken K. L. Yung, Daniel W. J. Kwong, Ricky M. S. Wong
  • Imaging Beta-Amyloid Peptides and Inhibition of Beta-Amyloid Peptide Aggregation
    Publication number: 20140212360
    Abstract: The present invention is in the field of pharmaceuticals and chemical industries. In particular, the present invention relates to methods for labeling, imaging and detecting the beta-amyloid (A?) peptides, oligomers, and fibrils in vitro by using carbazole-based fluorophores. A further aspect of the present invention relates to a method of reducing and preventing aggregation of beta-amyloid peptides for Alzheimer's disease (AD) as well as of treating and/or preventing Alzheimer's disease by using carbazole-based fluorophores.
    Type: Application
    Filed: March 31, 2014
    Publication date: July 31, 2014
    Applicant: Hong Kong Baptist University
    Inventors: Lei GUO, Di XU, See-Lok HO, Chung-Yan POON, Olivia T. W. NG, Hung Wing LI, Ken K. L. YUNG, Daniel W. J. KWONG, Ricky M. S. WONG
  • Imaging Beta-Amyloid Peptides and Inhibition of Beta-Amyloid Peptide Aggregation
    Publication number: 20140213614
    Abstract: The present invention is in the field of pharmaceuticals and chemical industries. In particular, the present invention relates to methods for labeling, imaging and detecting the beta-amyloid (A?) peptides, oligomers, and fibrils in vitro by using carbazole-based fluorophores. A further aspect of the present invention relates to a method of reducing and preventing aggregation of beta-amyloid peptides for Alzheimer's disease (AD) as well as of treating and/or preventing Alzheimer's disease by using carbazole-based fluorophores.
    Type: Application
    Filed: March 31, 2014
    Publication date: July 31, 2014
    Applicant: Hong Kong Baptist University
    Inventors: Lei GUO, Di XU, See-Lok HO, Chung-Yan POON, Olivia T. W. NG, Hung Wing LI, Ken K. L. YUNG, Daniel W. J. KWONG, Ricky M. S. WONG
  • Imaging Beta-Amyloid Peptides and Inhibition of Beta-Amyloid Peptide Aggregation
    Publication number: 20120269738
    Abstract: The present invention relates to methods of detecting and monitoring aggregation of beta-amyloid peptides which are associated with neurodegenerative diseases as well as treating and/or preventing the neurodegenerative diseases by using carbazole-based fluorophores. In particular, the present invention provides methods for labeling and imaging the beta-amyloid (A?) peptides, oligomers, and fibrils in vitro and/or in vivo, as well as treating and/or preventing Alzheimer's disease by using the carbazole-based fluorophores of the present invention.
    Type: Application
    Filed: April 13, 2012
    Publication date: October 25, 2012
    Applicant: Hong Kong Baptist University
    Inventors: Wanggui YANG, Yi WONG, Olivia T. W. NG, Hung Wing LI, Ken K. L. YUNG, Daniel W. J. KWONG, Ricky M. S. WONG