Abstract: Disclosed herein are devices, methods, and systems relating to in-situ calibration of biosensors. In an embodiment, a multiport stopcock device comprises: one or more inlet ports, receiving fluid from a fluid source, fluidically connected by a flow cell comprising one or more fluid channels, to one or more outlet ports; and a mechanism for diverting flow of fluid between ports and fluid channels, wherein: at least one of the one or more inlet ports comprises an inlet tip, connectable to a syringe, and a slip tip, connectable to said fluid source, and at least one of the one or more outlet ports comprises an inlet tip, connectable to a syringe, and a slip tip, connectable to a reservoir. Computer implemented methods of in-situ calibration of biosensors are disclosed. The devices, systems, and methods disclosed herein for in-situ calibration, may preferably decrease the risk of infection in patients requiring biofluid monitoring.

Abstract: Disclosed herein are computer-implemented methods and systems for assessing a risk value of a target patient, the method comprising: receiving at a server, via a connection mechanism, target patient data; estimating at the server, using one or more risk assessment models, one or more risk values associated with the target patient data. Target patient data may comprise historical data, patient population-level data, and real-time data. Risk assessment models may comprise one or more of: historical data risk assessment models, real-time data risk assessment models, or a combined risk assessment model. Methods for training such models are described. Systems and methods as described preferably enable continuous patient monitoring based on a patient's historical data and continuous, real-time physiological data.

Abstract: A monitoring device includes an input port attachable for fluid communication with a catheter, the catheter for insertion in a body of a user, for receiving fluid from the body of the user, an output port, generally parallel to the input port, in fluid communication with a fluid reservoir, a fluid channel defining fluid communication between the input port and the output port, and a biosensor for continuously measuring bio-signal data of the fluid in the fluid channel, the biosensor including an electrode pair. The biosensor is in communication with a computing device for determining a condition of the user based at least in part on the bio-signal data.