Abstract: The invention relates to various methods of detecting and analyzing protein interactions in a cell, which methods involve the appearance of a specific protein interaction being converted to a permanent detection signal by means of providing, in a manner dependent on said protein interaction, a recombinase activity or protease activity.

Abstract: The invention relates to the use of G-CSF for the treatment of cerebral stroke, particularly cerebral stroke with a large baseline infarct volume. Administration of G-CSF at a total dose of 30 to 180 ?g per kg body weight over a treatment period of about 3 days is suitable for the treatment of stroke. Treatment in accordance with the invention with a total dose of 80 to 150 ?g per kg body weight is preferred.

Abstract: The present invention relates to the use of piperine and derivatives thereof for the preparation of a pharmaceutical composition for treating and/or preventing a neuronal condition where there is a need of neuroprotection and/or neuroregeneration. The invention furthermore relates to the use of piperine and derivatives thereof for the in vitro differentiation of neural stem cells and the use of such pre-treated cells for stem cell therapy von neurological conditions.

Abstract: The invention relates to various methods of detecting and analyzing protein interactions in a cell, which methods involve the appearance of a specific protein interaction being converted to a permanent detection signal by means of providing, in a manner dependent on said protein interaction, a recombinase activity or protease activity.

Abstract: Described are various methods of detecting and analyzing protein interactions in a cell. The specific protein interaction is detected by a permanent signal generated by a recombinase activity or protease activity that depends on the protein interaction.

Abstract: The invention relates to a method of detecting and analyzing protein interactions in a cell, which comprises the steps: d) provision of the activity of at least one enzyme from the group consisting of recombinases and proteases in the cell as a result of a protein interaction, e) continual generation of an active reporter protein in the cell in question as a result of the enzymic activity of step a) for a period of time which exceeds the duration of the protein interaction of step a), f) generation of a detection signal by the reporter proteins generated in b). The invention furthermore relates to reverse embodiments of the method above of detecting and analyzing protein interactions in a cell, with, as a result of the induced dissociation of a defined interaction between proteins, the activity of at least one enzyme from the group consisting of recombinases and proteases being provided in the cell and converted to a permanent detection signal of said cell.