Abstract: An electric discharge apparatus includes electrode specification input means for inputting each electrode specification of a plurality of integral electrode where electrodes corresponding to a plurality of machining forms are arranged continuously on the same axis, machining detail input means for inputting data of a workpiece when electric discharge machining is performed using the integral electrode, and a machining program generation means for generating a machining program consisting of machining start position and a machining depth when electric discharge machining is performed using each electrodes based on the electrode specification and the thickness data of the workpiece thus input.

Abstract: An electric discharge apparatus includes electrode specification input means for inputting each electrode specification of a plurality of integral electrode where electrodes corresponding to a plurality of machining forms are arranged continuously on the same axis, machining detail input means for inputting data of a workpiece when electric discharge machining is performed using the integral electrode, and a machining program generation means for generating a machining program consisting of machining start position and a machining depth when electric discharge machining is performed using each electrodes based on the electrode specification and the thickness data of the workpiece thus input.

Abstract: [Problems] To provide a novel cyclic isodityrosine derivative having a physiological effect. [Means for solving problems] A compound represented by general formula (I) or a pharmacologically acceptable salt thereof has an effect of potentiating activity of imipenem, an effect of inhibiting the synthesis of a cholesteryl ester, and so forth: wherein R1 represents a hydrogen atom, an amido group, a Boc group, a Cbz group, an Fmoc group, a BocNH(CH2)5CO— group, a BocNHCH(CH2C6H5)CO— group, or a linear or branched alkyl group; R2 represents a benzoyl group, a benzyl group, a modified benzyl group, or a linear or branched alkyl group; R3 represents a hydrogen group, an —OR5 group, wherein R5 represents a linear or branched alkyl group or an aromatic ring, or an amido group; R4 represents a hydrogen atom, or a linear or branched alkyl group; and X1 and X2 each represent a halogen atom, wherein X1 and X2 may be the same as or different from each other.

Abstract: The present invention relates to antitumor 4'-demethylepipodophyllotoxin glycosides having the formula ##STR1## wherein R is a pentose selected from the group consisting of .beta.-D-ribopyranosyl, peracyl .beta.-D-ribopyranosyl, .beta.-D-xylopyranosyl, peracyl .beta.-D-xylopyranosyl, .alpha.-D-xylopyranosyl, peracyl .alpha.-D-xylopyranosyl, .alpha.-D-arabinopyranosyl, 3,4-O-(C.sub.1-4)alkylidene-D-ribopyranosyl, 2-O-acyl-3,4-O-(C.sub.1-4)alkylidene-D-ribopyranosyl, and .beta.-D-ribofuranosyl; P is hydrogen, or --PO.sub.3 H.sub.2 or a pharmaceutically acceptable salt thereof.

Abstract: The epipodophyllotoxin glucosides disclosed are acylated at herein one or both sugar hydroxyl groups. These compounds exhibit significant activity against P388 murine leukemia.