Patents by Inventor Rikke E. Humble

Rikke E. Humble has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Intermediates for the preparation of citalopram and escitalopram
    Patent number: 7687645
    Abstract: Methods for manufacture of 5-alkoxycarbonylphthtalides are disclosed. The 5-alkoxycarbonylphthtalides are useful in syntheses of the well-known antidepresssants citalopram and escitalopram.
    Type: Grant
    Filed: March 17, 2004
    Date of Patent: March 30, 2010
    Assignee: H. Lundbeck A/S
    Inventors: Thomas Pittelkow, Andrea Castellin, Federico Sbrogiò, Poul D. Nielsen, Jacobo Zanon, Steen Sogaard, Rikke E. Humble
  • Process for the preparation of racemic citalopram diol and/or - or -citalopram diols and the use of such diols for the preparation of racemic citalopram, -citalopram and/or -citalopram
    Patent number: 7390913
    Abstract: In the following, citalopram diol means 4-(4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl)-benzonitrile, as free base and/or acid addition salt. The invention relates to a process for the preparation of racemic citalopram diol and/or R- or S-citalopram diol, comprising the separation of a non-racemic mixture of R- and S-citalopram diol with more than 50% of one of the enantiomers into a fraction being enriched with S- or R-citalopram diol and a fraction comprising RS-citalopram diol wherein the ratio of R-citalopram diol:S-citalopram diol is equal to 1:1 or closer to 1:1 than in the initial mixture.
    Type: Grant
    Filed: December 18, 2003
    Date of Patent: June 24, 2008
    Assignee: H. Lundbeck A/S
    Inventors: Hans Petersen, Brian Christiansen, Robert Dancer, Rikke E. Humble
  • Process for the preparation of racemic citalopram and/or S-or R-citalopram by separation of a mixture of R-and S-citalopram
    Patent number: 7112686
    Abstract: The invention relates to a process for the preparation of racemic citalopram free base or an acid addition salt thereof and/or R- or S-citalopram as the free base or an acid addition salt thereof by separation of a mixture of R- and S-citalopram with more than 50% of one of the enantiomers into a fraction consisting of racemic citalopram and/or a fraction of S-citalopram or R-citalopram characterized in that i) citalopram is precipitated from a solvent as the free base or as an acid addition salt thereof; ii) the precipitate formed is separated from the mother liquor; iia) if the precipitate is crystalline it is optionally recrystallised one or more times to form racemic citalopram, and then optionally converted into an acid addition salt thereof; iib) if the precipitate is not crystalline, steps i) and ii) are optionally repeated until a crystalline precipitate is obtained and the crystalline precipitate is recrystallised one or more times to form racemic citalopram, and then optionally converted into an aci
    Type: Grant
    Filed: June 25, 2002
    Date of Patent: September 26, 2006
    Assignee: H. Lundbeck A/S
    Inventors: Rikke E. Humble, Troels V. Christensen, Michael H. Rock, Ole Nielsen, Hans Petersen, Robert Dancer
  • Process for the preparation of racemic citalopram and/or s-or r-citalopram by separation of a mixture of r-and s-citalopram
    Publication number: 20040259940
    Abstract: The invention relates to a process for the preparation of racemic citalopram free base or an acid addition salt thereof and/or R- or S-citalopram as the free base or an acid addition salt thereof by separation of a mixture of R- and S-citalopram with more than 50% of one of the enantiomers into a fraction consisting of racemic citalopram and/or a fraction of S-citalopram or R-citalopram characterized in that i) citalopram is precipitated from a solvent as the free base or as an acid addition salt thereof; ii) the precipitate formed is separated from the mother liquor; iia) if the precipitate is crystalline it is optionally recrystallised one or more times to form racemic citalopram, and then optionally converted into an acid addition salt thereof; iib) if the precipitate is not crystalline, steps i) and ii) are optionally repeated until a crystalline precipitate is obtained and the crystalline precipitate is recrystallised one or more times to form racemic citalopram, and then optionally converted into an aci
    Type: Application
    Filed: February 9, 2004
    Publication date: December 23, 2004
    Inventors: Rikke E. Humble, Troels v Christensen, Michael h Rock, Ole Nielsen, Hans Petersen, Robert Dancer