Patents by Inventor Rima McLeod

Rima McLeod has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200289629
    Abstract: Disclosed herein are polynucleotides encoding multi-epitope polypeptides and assemblies thereof, and their use for treating or limiting Toxoplasma gondii infection.
    Type: Application
    Filed: June 3, 2020
    Publication date: September 17, 2020
    Inventors: Rima MCLEOD, Kamal EL BISSATI, Ying ZHOU, Jeff ALEXANDER, Lo VANG, Steve REED, Sara M. PAULILLO, Senthil K. RAMAN, Peter BURKHARD, Mariane MELO, Darrel IRVINE, Ron WEISS, Yuan ZHANG, Alessandro SETTE, John SIDNEY, Brian D. LIVINGSTON, Hernan LORENZI
  • Publication number: 20200283391
    Abstract: Disclosed herein; are novel compounds for treating apicomplexan parasite related disorders, methods for their use; cell line and non-human animal models of the dormant parasite phenotype and methods for their use in identifying new drugs to treat apicomplexan parasite related disorders, and biomarkers to identify disease due to the parasite and its response to treatment.
    Type: Application
    Filed: December 20, 2016
    Publication date: September 10, 2020
    Inventors: Rima McLeod, Martin McPhillie, Colin W.G. Fishwick, Hernan Alejandro Lorenzi, Kai Wang, Taek-Kyun Kim, Yong Zhou, Leroy E. Hood, Ying Zhou, Kamal El Bissati, James Gordon, Mark Hickman, QiGui Li, Craig Roberts
  • Publication number: 20200057057
    Abstract: Point-of-care (POC) testing for T. gondii infection can potentially address cost concerns and lead to better clinical outcomes through improved access to screening. This disclosure provides methods and compositions for whole blood POC testing to identify T. gondii infection with high sensitivity and specificity, obviating the need for venipuncture and sample processing infrastructure, making it an efficient, low-cost POC test.
    Type: Application
    Filed: August 16, 2019
    Publication date: February 20, 2020
    Inventors: Denis LIMONNE, Rima MCLEOD, Francois PEYRON, Kamal EL-BISSATI, Joe LYKINS
  • Publication number: 20190282679
    Abstract: Disclosed herein are polynucleotides encoding multi-epitope polypeptides and assemblies thereof, and their use for treating or limiting Toxoplasma gondii infection.
    Type: Application
    Filed: April 14, 2017
    Publication date: September 19, 2019
    Inventors: Rima MCLEOD, Kamal EL BISSATI, Ying ZHOU, Jeff ALEXANDER, Lo VANG, Steve REED, Sara M. PAULILLO, Senthil K. RAMAN, Peter BURKHARD, Mariane MELO, Darrel IRVINE, Ron WEISS, Yuan ZHANG, Alessandro SETTE, John SIDNEY, Brian D. LIVINGSTON, Hernan LORENZI
  • Patent number: 9408899
    Abstract: Vaccines are disclosed against parasites. The vaccines include peptides in an immunological composition. In particular, the parasite is Toxoplas gondii.
    Type: Grant
    Filed: November 3, 2011
    Date of Patent: August 9, 2016
    Assignees: The University of Chicago, Infectious Disease Research Institute, Paxvax, Inc.
    Inventors: Rima McLeod, Tze Guan Tan, Jeffery L. Alexander, Hua Cong, William H. Witola, Kamal El Bissati, Ernest J. Mui, Steven G. Reed
  • Publication number: 20130324555
    Abstract: The present invention is directed to the method of use of effective pharmaceutical formulations for the treatment of diseases caused by apicomplexan parasites, said formulation comprised of a salicylanilide or salicylanilide derivative, disclosed herein, alone or in combination with one or more other active or excipient pharmaceutical substances. The present invention is further directed to the method of use of effective pharmaceutical formulations for the treatment of diseases caused by apicomplexan parasites, said formulation comprised of a combination of salicylanilides or salicylanilide derivatives, disclosed herein. The present invention is further directed to the method of use of effective pharmaceutical formulations for the treatment of diseases caused by apicomplexan parasites, said formulation comprised of a combination of salicylanilides or salicylanilide derivatives, disclosed herein, further comprised of one or more active or excipient pharmaceutical substances.
    Type: Application
    Filed: May 29, 2013
    Publication date: December 5, 2013
    Inventors: Richard Delarey Wood, Rima McLeod, Ernest Mui, Alina Fomovska, William Welsh
  • Patent number: 8575126
    Abstract: Pharmaceutical formulations of antisense peptide-conjugated phosphorodiamidate morpholino olgomers and methods of use for treatment of apicomplexan infections are disclosed. The invention is particularly directed to treatment of Toxoplasma gondii infections.
    Type: Grant
    Filed: June 27, 2012
    Date of Patent: November 5, 2013
    Inventors: Rima McLeod, Bo Shiun Lai, William Witola, Kamal El Bissati, Ernest Mui, Hong Moulton, Jonathan B Rothbard, Jon D Moulton
  • Publication number: 20130273094
    Abstract: Vaccines are disclosed against parasites. The vaccines include peptides in an immunological composition. In particular, the parasite is Toxoplas gondii.
    Type: Application
    Filed: November 3, 2011
    Publication date: October 17, 2013
    Applicants: THE UNIVERSITY OF CHICAGO, PAXVAX, INC., INFECTIOUS DISEASE RESEARCH INSTITUTE
    Inventors: Rima McLeod, Tze Guan Tan, Jeffery L. Alexander, Hua Cong, William H. Witola, Kamal El Bissati, Ernest J. Mui, Steven G. Reed
  • Publication number: 20130053427
    Abstract: Pharmaceutical formulations of antisense peptide-conjugated phosphorodiamidate morpholino olgomers and methods of use for treatment of apicomplexan infections are disclosed. The invention is particularly directed to treatment of Toxoplasma gondii infections.
    Type: Application
    Filed: June 27, 2012
    Publication date: February 28, 2013
    Inventors: Rima McLeod, Bo Shiun Lai, William Witola, Kamal El Bissati, Ernest Mui, Hong Moulton, Jonathan B. Rothbard, Jon D. Moulton
  • Publication number: 20090156687
    Abstract: Discovery and characterization of an apicomplexan Fab I gene and encoded enzyme and discovery of the triclosan as a lead compound, provide means to rationally design novel inhibitory compositions useful for prevention and treatment of apicomplexan related diseases.
    Type: Application
    Filed: November 5, 2007
    Publication date: June 18, 2009
    Inventors: Rima McLeod, Michael Kirisits, Dennis Kyle, Douglas G. Mack, Wilbur Milhous, Stephen Muench, Ernest J. Mui, Sean Prigge, John Rafferty, David Rice, Craig W. Roberts, Benjamin Samuel
  • Publication number: 20050142113
    Abstract: This invention relates uses of components of plant-like metabolic pathways not including psbA or PPi phosphofructokinase and not generally operative in animals or encoded by the plastid DNA, to develop compositions that interfere with Apicomplexan growth and survival. Components of the pathways include enzymes, transit peptides and nucleotide sequences encoding the enzymes and peptides, or promoters of these nucleotide sequences to which antibodies, antisense molecules and other inhibitors are directed. Diagnostic and therapeutic reagents and vaccines are developed based on the components and their inhibitors.
    Type: Application
    Filed: April 14, 2004
    Publication date: June 30, 2005
    Inventors: Rima McLeod, Craig Roberts, Fiona Roberts, Jennifer Johnson, Michael Kirisits, David Ferguson, Russell Lyons, Ernest Mui, Doug Mack, Benjamin Samuel, Piotr Gornicki, Ellen Zuther
  • Publication number: 20040137446
    Abstract: Discovery and characterization of an apicomplexan Fab I gene and encoded enzyme and discovery of the triclosan as a lead compound, provide means to rationally design novel inhibitory compositions useful for prevention and treatment of apicomplexan related diseases.
    Type: Application
    Filed: June 18, 2003
    Publication date: July 15, 2004
    Inventors: Rima McLeod, Stephen P. Muench, John B. Rafferty, Dennis E. Kyle, Ernest J. Mui, Michael J. Kirisits, Douglas G. Mack, Craig W. Roberts, Benjamin U. Samuel, Russell E. Lyons, Wilbur K. Milhous, Sean Prigge, David W. Rice