Patents by Inventor Rimma Sandler Bradley

Rimma Sandler Bradley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Diheterocyclic metalloprotease inhibitors
    Patent number: 6399598
    Abstract: The invention provides compounds of formula as described in the claims, or an optical isomer, diastereomer or enantiomer thereof, or a pharmaceutically-acceptacle salt, or biohydrolyzable amide, ester, or imide thereof are useful as inhibitors of metalloproteases. Also disclosed are pharmaceutical compositions and methods of treating diseases, disorders and conditions characterized by metalloprotease activity using these compounds or the pharmaceutical compositions containing them.
    Type: Grant
    Filed: March 1, 2000
    Date of Patent: June 4, 2002
    Assignee: The Procter & Gamble Company
    Inventors: Stanislaw Pikul, Neil Gregory Almstead, Rimma Sandler Bradley, Kelly Lynn McDow-Dunham, Biswanath De, Michael George Natchus, Yetunde Olabisi Taiwo, Thomas Lee Cupps
  • Acyclic metalloprotease inhibitors
    Patent number: 6218389
    Abstract: The invention provides compounds of formula as described in the claims, or an optical isomer, diastereomer or enantiomer thereof, or a pharmaceutically-acceptable salt, or biohydrolyzable amide, ester, or imide thereof are useful as inhibitors of metalloproteases. Also disclosed are pharmaceutical compositions and methods of treating diseases, disorders and conditions characterized by metalloprotease activity using these compounds or the pharmaceutical compositions containing them.
    Type: Grant
    Filed: July 31, 1998
    Date of Patent: April 17, 2001
    Assignee: The Procter & Gamble Co.
    Inventors: Neil Gregory Almstead, Roger Gunnard Bookland, Yetunde Olabisi Taiwo, Rimma Sandler Bradley, Rodney Dean Bush, Biswanath De, Michael George Natchus, Stanislaw Pikul
  • Bidentate metalloprotease inhibitors
    Patent number: 6121272
    Abstract: The invention provides compounds which are useful as inhibitors of metalloproteases, and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the present invention relates to a compound having a structure according to Formula (I) ##STR1## as described in the claims, or an optical isomer, diastereomer or enantiomer thereof, or a pharmaceutically-acceptable salt, or biohydrolyzable alkoxyamide, ester, acyloxyamide, or imide thereof. Also disclosed are compounds, pharmaceutical compositions and methods of treating diseases characterized by metalloprotease activity using these compounds or the pharmaceutical compositions containing them.
    Type: Grant
    Filed: August 26, 1997
    Date of Patent: September 19, 2000
    Assignee: The Procter & Gamble Company
    Inventors: Neil Gregory Almstead, Biswanath De, Rimma Sandler Bradley, Garry Steven Garrett, John Emory Marlin, II, John McMillan McIver, Zhe Wang, Yetunde Olabisi Taiwo
  • 1,5-heterocyclic metalloprotease inhibitors
    Patent number: 6121258
    Abstract: The invention provides compounds of formula ##STR1## as described in the claims, or an optical isomer, diastereomer or enantiomer thereof, or a pharmaceutically-acceptable salt, or biohydrolyzable amide, ester, or imide thereof are useful as inhibitors of metalloproteases.Also disclosed are pharmaceutical compositions and methods of treating diseases, disorders and conditions characterized by metalloprotease activity using these compounds or the pharmaceutical compositions containing them.
    Type: Grant
    Filed: August 26, 1997
    Date of Patent: September 19, 2000
    Assignee: The Procter & Gamble Company
    Inventors: Stanislaw Pikul, Neil Gregory Almstead, Rimma Sandler Bradley, Kelly Lynn McDow-Dunham, Biswanath De, Michael George Natchus, Yetunde Olabisi Taiwo, Thomas Lee Cupps
  • Spirocyclic containing hydroxamic acids useful as metalloprotease inhibitors
    Patent number: 6015912
    Abstract: The invention provides compounds of formula ##STR1## as described in the claims, or an optical isomer, diastereomer or enantiomer thereof, or a pharmaceutically-acceptable salt, or biohydrolyzable amide, ester, or imide thereof are useful as inhibitors of metalloproteases.Also disclosed are pharmaceutical compositions and methods of treating diseases, disorders and conditions characterized by metalloprotease activity using these compounds or the pharmaceutical compositions containing them.
    Type: Grant
    Filed: August 26, 1997
    Date of Patent: January 18, 2000
    Assignee: The Procter & Gamble Company
    Inventors: Zhe Wang, Neil Gregory Almstead, Rimma Sandler Bradley, Michael George Natchus, Biswanath De, Stanislaw Pikul, Yetunde Olabisi Taiwo