Abstract: Disclosed are methods of treating cardiac injury in a subject comprising administering a therapeutically effective amount of angiotensin II to the subject. Also disclosed are methods of treating catecholamine-associated cardiac injury in a subject comprising administering a therapeutically effective amount of angiotensin II to the subject. The subject can have cardiac injury, or the subject can be at risk of having cardiac injury.

Abstract: Provided herein are methods for treating or preventing a condition, and/or symptom or clinical manifestation, associated with systemic infection wherein a subject is intravenously administered ascorbic acid or a pharmaceutically acceptable salt, ester or isomer thereof in an amount of between about 700 mg/kg body weight and about 4,000 mg/kg body weight per day, optionally as a first bolus infusion followed by a subsequent continuous infusion. Also provided are methods comprising intravenously administering to the subject ascorbic acid or a pharmaceutically acceptable salt, ester or isomer thereof: (i) as a bolus dose of from about 350 mg/kg body weight to about 500 mg/kg body weight; and (ii) following (i), by continuous infusion over at least several hours at a dose of from about 60 mg/kg body weight/hr to about 500 mg/kg body weight/hr. Typically, the condition is sepsis or septic shock.

Abstract: Provided are methods and compositions for predicting the development of kidney disease, including acute kidney injury. In certain aspects and embodiments the provided methods and compositions are particularly useful for predicting kidney injury following an event likely to cause kidney injury and/or kidney failure in a patient, such as a cardiac surgery, e.g., a surgery involving a cardiopulmonary bypass (CPB), such as a coronary artery bypass graft surgery. In some embodiments, the higher the urinary hepcidin-to-urinary creatinine ratio (uHep/uCr) at 6-24 hours following initiation of CPB, the lower is the risk for development of AKI determined by RIFLE criteria in the ensuing four to five days. Conversely, the higher the urinary NGAL to urinary creatinine ratio (uNGAL/uCr) at 6-24 hours following initiation of CPB, the higher is the risk of developing CPB-mediated AKI over the same time period.

Abstract: Provided are methods and compositions for predicting the development of kidney disease, including acute kidney injury. In certain aspects and embodiments the provided methods and compositions are particularly useful for predicting kidney injury following an event likely to cause kidney injury and/or kidney failure in a patient, such as a cardiac surgery, e.g., a surgery involving a cardiopulmonary bypass (CPB), such as a coronary artery bypass graft surgery. In some embodiments, the higher the urinary hepcidin-to-urinary creatinine ratio (uHep/uCr) at 6-24 hours following initiation of CPB, the lower is the risk for development of AKI determined by RIFLE criteria in the ensuing four to five days. Conversely, the higher the urinary NGAL to urinary creatinine ratio (uNGAL/uCr) at 6-24 hours following initiation of CPB, the higher is the risk of developing CPB-mediated AKI over the same time period.

Abstract: A method for determining the likelihood of a medical event occurring, comprising the steps of applying a data mining technique to a dataset containing temporal patient data, wherein the data mining technique provides information regarding the likelihood of a medical event occurring.

Abstract: The present invention provides a method of attenuating or preventing acute kidney injury occurring in a subject following cardiac surgery involving cardio-pulmonary bypass. The method comprises administration of at least one agent which cause alkalinization of urine to the subject at a level effective to cause alkalinization of the subject's urine. Preferably the agent which cause alkalinization of urine is selected from the group consisting of sodium bicarbonate, lactate, acetate, citrate, tromethamine and combinations thereof and is most preferably sodium bicarbonate.

Abstract: The present invention relates generally to a method of treatment and in particular a method of treating a subject exhibiting symptoms of kidney failure or are at risk of developing same.