Patents by Inventor Rinat Esenaliev
Rinat Esenaliev has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230233088Abstract: The systems, devices, and methods herein make optoacoustic measurements and correct or normalize them for variations in optical energy level of the different light pulses used. An optical source directs optical pulses to tissue, an optical energy meter measures the optical energy of the different optical pulses, an acoustic detector measures an acoustic response generated by the tissue in response to the optical pulses, and a processor calculates a concentration of an analyte based on the measured acoustic response and as corrected or normalized for the different energy levels among the optical pulses.Type: ApplicationFiled: March 21, 2023Publication date: July 27, 2023Inventors: Rinat ESENALIEV, Irene Petrov, Yuriy Petrov
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Patent number: 11045121Abstract: Optoacoustic diagnostic systems, devices, and methods are described. A system may comprise a console unit and a handheld probe. The console unit comprises a controller, a processor, a photodiode array, an acoustic processing subsystem, and a cooling subsystem. The probe directs light signals from the photodiode array to patient tissue. The light signals each have different wavelengths selected based on the physiological parameter of interest. The probe further comprises an acoustic transducer that receives acoustic signals generated in response to the directed light signals. The probe may comprise a finger-held working end that can be directed to the skull of a fetus within the uterus during labor. The probe can then accurately determine blood oxygenation of the fetus to determine if a caesarian section is necessary.Type: GrantFiled: January 22, 2019Date of Patent: June 29, 2021Assignee: Noninvasix, Inc.Inventors: Rinat Esenaliev, Donald S. Prough, Yuriy Petrov, Irene Petrov, George Saade, Gayle L. Olson, Tommy G. Cooper
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Publication number: 20190216376Abstract: Optoacoustic diagnostic systems, devices, and methods are described. A system may comprise a console unit and a handheld probe. The console unit comprises a controller, a processor, a photodiode array, an acoustic processing subsystem, and a cooling subsystem. The probe directs light signals from the photodiode array to patient tissue. The light signals each have different wavelengths selected based on the physiological parameter of interest. The probe further comprises an acoustic transducer that receives acoustic signals generated in response to the directed light signals. The probe may comprise a finger-held working end that can be directed to the skull of a fetus within the uterus during labor. The probe can then accurately determine blood oxygenation of the fetus to determine if a caesarian section is necessary.Type: ApplicationFiled: January 22, 2019Publication date: July 18, 2019Inventors: Rinat ESENALIEV, Donald S. PROUGH, Yuriy PETROV, Irene PETROV, George SAADE, Gayle L. OLSON, Tommy G. COOPER
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Patent number: 10307088Abstract: Optoacoustic diagnostic systems, devices, and methods are described. A system may comprise a console unit and a handheld probe. The console unit comprises a controller, a processor, a photodiode array, an acoustic processing subsystem, and a cooling subsystem. The probe directs light signals from the photodiode array to patient tissue. The light signals each have different wavelengths selected based on the physiological parameter of interest. The probe further comprises an acoustic transducer that receives acoustic signals generated in response to the directed light signals. The probe may comprise a finger-held working end that can be directed to the skull of a fetus within the uterus during labor. The probe can then accurately determine blood oxygenation of the fetus to determine if a caesarian section is necessary.Type: GrantFiled: July 8, 2015Date of Patent: June 4, 2019Assignee: The Board of Regents of the University of TexasInventors: Rinat Esenaliev, Donald S. Prough, Yuriy Petrov, Irene Petrov, George Saade, Gayle L. Olson
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Patent number: 10231656Abstract: Optoacoustic diagnostic systems, devices, and methods are described. A system may comprise a console unit and a handheld probe. The console unit comprises a controller, a processor, a photodiode array, an acoustic processing subsystem, and a cooling subsystem. The probe directs light signals from the photodiode array to patient tissue. The light signals each have different wavelengths selected based on the physiological parameter of interest. The probe further comprises an acoustic transducer that receives acoustic signals generated in response to the directed light signals. The probe may comprise a finger-held working end that can be directed to the skull of a fetus within the uterus during labor. The probe can then accurately determine blood oxygenation of the fetus to determine if a caesarian section is necessary.Type: GrantFiled: July 8, 2015Date of Patent: March 19, 2019Assignees: Noninvasix, Inc., The Board of Regents of The University of TexasInventors: Rinat Esenaliev, Donald S. Prough, Yuriy Petrov, Irene Petrov, George Saade, Gayle L. Olson, Tommy G. Cooper
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Patent number: 9380967Abstract: Optoacoustic diagnostic systems, devices, and methods are described. A system may comprise a console unit and a handheld probe. The console unit comprises a controller, a processor, a photodiode array, an acoustic processing subsystem, and a cooling subsystem. The probe directs light signals from the photodiode array to patient tissue. The light signals each have different wavelengths selected based on the physiological parameter of interest. The probe further comprises an acoustic transducer that receives acoustic signals generated in response to the directed light signals. The probe may comprise a finger-held working end that can be directed to the skull of a fetus within the uterus during labor. The probe can then accurately determine blood oxygenation of the fetus to determine if a caesarian section is necessary.Type: GrantFiled: July 8, 2015Date of Patent: July 5, 2016Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEMInventors: Rinat Esenaliev, Donald S. Prough, Yuriy Petrov, Irene Petrov, George Saade, Gayle L. Olson
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Publication number: 20160015304Abstract: Optoacoustic diagnostic systems, devices, and methods are described. A system may comprise a console unit and a handheld probe. The console unit comprises a controller, a processor, a photodiode array, an acoustic processing subsystem, and a cooling subsystem. The probe directs light signals from the photodiode array to patient tissue. The light signals each have different wavelengths selected based on the physiological parameter of interest. The probe further comprises an acoustic transducer that receives acoustic signals generated in response to the directed light signals. The probe may comprise a finger-held working end that can be directed to the skull of a fetus within the uterus during labor. The probe can then accurately determine blood oxygenation of the fetus to determine if a caesarian section is necessary.Type: ApplicationFiled: July 8, 2015Publication date: January 21, 2016Inventors: Rinat ESENALIEV, Donald S. PROUGH, Yuriy PETROV, Irene PETROV, George SAADE, Gayle L. OLSON, Tommy G. COOPER
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Publication number: 20160007895Abstract: Optoacoustic diagnostic systems, devices, and methods are described. A system may comprise a console unit and a handheld probe. The console unit comprises a controller, a processor, a photodiode array, an acoustic processing subsystem, and a cooling subsystem. The probe directs light signals from the photodiode array to patient tissue. The light signals each have different wavelengths selected based on the physiological parameter of interest. The probe further comprises an acoustic transducer that receives acoustic signals generated in response to the directed light signals. The probe may comprise a finger-held working end that can be directed to the skull of a fetus within the uterus during labor. The probe can then accurately determine blood oxygenation of the fetus to determine if a caesarian section is necessary.Type: ApplicationFiled: July 8, 2015Publication date: January 14, 2016Inventors: Rinat ESENALIEV, Donald S. PROUGH, Yuriy PETROV, Irene PETROV, George SAADE, Gayle L. OLSON
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Publication number: 20160007892Abstract: Optoacoustic diagnostic systems, devices, and methods are described. A system may comprise a console unit and a handheld probe. The console unit comprises a controller, a processor, a photodiode array, an acoustic processing subsystem, and a cooling subsystem. The probe directs light signals from the photodiode array to patient tissue. The light signals each have different wavelengths selected based on the physiological parameter of interest. The probe further comprises an acoustic transducer that receives acoustic signals generated in response to the directed light signals. The probe may comprise a finger-held working end that can be directed to the skull of a fetus within the uterus during labor. The probe can then accurately determine blood oxygenation of the fetus to determine if a caesarian section is necessary.Type: ApplicationFiled: July 8, 2015Publication date: January 14, 2016Inventors: Rinat ESENALIEV, Donald S. PROUGH, Yuriy PETROV, Irene PETROV, George SAADE, Gayle L. OLSON
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Patent number: 7863038Abstract: A new class of biosensors and methods for making and using same are disclosed. The biosensors are multi-layered membrane composites, where at least one layer is prepared by the layer-by-layer process and at least one layer is responsive to changes is a property of a biological system such as changes in the concentration of an atom, ion, molecule or molecular assembly. Because the biosensors are multi-layered, a single biosensor is capable monitor a number of different properties of a biological system simultaneously. The biosensors are monitored by systems that impinge an excitation waveform on the biosensors and analyze a reflected and/or a transmitted resultant waveform. Additionally, the biosensors can be associated with field activated electronic components so that implantable, self-contained analytical devices can be constructed and monitored by field generators, where data is transmitted to an analyzer after field activation.Type: GrantFiled: March 31, 2003Date of Patent: January 4, 2011Assignee: Board of Regents, The University of Texas SystemInventors: Massoud Motamedi, Nicholas A. Kotov, James P. Wicksted, Rinat Esenaliev
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Publication number: 20070255141Abstract: New methods and systems for noninvasive glucose monitoring and sensing with electromagnetic waves or ultrasound are disclosed. The methods are based on absolute or relative measurement of tissue dimensions (or changes in the dimensions) including, but not limited to: thickness, length, width, diameter, curvature, roughness as well as time of flight of ultrasound and optical pulses and optical thickness, which change with changing blood glucose concentrations. By measuring noninvasively absolute or relative changes in at least one dimension of at least one tissue or tissue layer or absolute or relative changes in time of flight of ultrasound or optical pulses, one can monitor blood glucose concentration noninvasively.Type: ApplicationFiled: January 22, 2007Publication date: November 1, 2007Inventors: Rinat Esenaliev, Donald Prough
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Publication number: 20070232872Abstract: New optical coherence tomography (OCT) techniques are disclosed which are designed to improve OCT glucose concentration measure accuracy and are capable of being performed on a continuous basis. New multi-wavelength optical coherence tomography (OCT) techniques are also disclosed and designed to reduce artifacts do to water. New optical coherence tomography (OCT) techniques are also disclosed for determining local profusion rates, local analyte transport rates and tissue analyte transport rates as a measure of tissue health, disease progression and state and tissue transplantation effectiveness.Type: ApplicationFiled: March 13, 2007Publication date: October 4, 2007Applicant: The Board of Regents of The University of Texas SystemInventors: Donald Prough, Rinat Esenaliev, Massoud Motamedi
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Publication number: 20070232873Abstract: A new OCT system and method are disclosed, where the system includes a probe equipped with a heating element and a high heat conductive member to warm a tissue site to be scanned to an elevated and/or to maintain the elevated tissue temperature with a temperature variation of less than or equal to 1° C. to improve an accuracy and reliability of an OCT glucose concentration value other long measurement durations. The new OCT system and method can also be equipped with pressure components to reduce a pressure exerted on the tissue site to a minimal constant pressure.Type: ApplicationFiled: March 13, 2007Publication date: October 4, 2007Applicant: The Board of Regents of The University of Texas SyatemInventors: Rinat Esenaliev, Donald Prough
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Publication number: 20070078290Abstract: The disclosure provides a method and apparatus for noninvasive and minimally-invasive treatment of skin and subcutaneous tissues with ultrasound with or without nano- or microparticles. The treatment includes, but is not limited to, hair removal, skin rejuvenation (wrinkle removal), scar removal, treatment of spider veins and varicose veins, removal of birthmarks, acne treatment, wound treatment, abnormal pigmentation and stretch mark removal, abnormal tissues in skin and subcutaneous layers, and tattoo removal. Skin and subcutaneous tissues which can be treated with the methods described include, but are not limited to, the dermis, epidermis, subcutaneous fat, connective tissue, muscle tissue, blood vessels, scar tissues, tendons, and cartilage tissues, and abnormal tissues in skin and subcutaneous layers. The disclosure is especially applicable to hair removal and skin rejuvenation.Type: ApplicationFiled: October 2, 2006Publication date: April 5, 2007Inventor: Rinat Esenaliev
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Patent number: 6751490Abstract: An optoacoustic apparatus is disclosed which includes a radiation source of pulsed optical radiation and a probe having a front face to be placed in contact with a tissue site of an animal body. The probe further includes an optical fiber terminating at the surface of the front face of the probe and connected to a pulsed laser. The front face of the probe also has mounted therein or thereon a piezoelectric transducer for detecting an acoustic response to the radiation pulses connected to a processing unit which converts the transducer signal into a measure of hemoglobin concentration and/or hematocrit of blood.Type: GrantFiled: March 1, 2001Date of Patent: June 15, 2004Assignee: The Board of Regents of the University of Texas SystemInventors: Rinat Esenaliev, Massoud Motamedi, Donald Prough
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Publication number: 20040054268Abstract: An optoacoustic apparatus is disclosed which includes a radiation source of pulsed radiation and a probe having a front face to be placed in contact with a tissue site of an animal body. The probe further includes an optical fiber terminating at the surface of the front face of the probe and connected at their other end to a pulsed laser. The front face of the probe also has mounted therein or thereon a piezoelectric transducer for detecting an acoustic response to the radiation pulses connected to a processing unit which converts the transducer signal into a measure of hemoglobin concentration and/or hematocrit of blood.Type: ApplicationFiled: March 1, 2001Publication date: March 18, 2004Inventors: Rinat Esenaliev, Massoud Motamedi, Donald Prough
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Publication number: 20040023317Abstract: A new class of biosensors and methods for making and using same are disclosed. The biosensors are multi-layered membrane composites, where at least one layer is prepared by the layer-by-layer process and at least one layer is responsive to changes is a property of a biological system such as changes in the concentration of an atom, ion, molecule or molecular assembly. Because the biosensors are multi-layered, a single biosensor is capable monitor a number of different properties of a biological system simultaneously. The biosensors are monitored by systems that impinge an excitation waveform on the biosensors and analyze a reflected and/or a transmitted resultant waveform. Additionally, the biosensors can be associated with field activated electronic components so that implantable, self-contained analytical devices can be constructed and monitored by field generators, where data is transmitted to an analyzer after field activation.Type: ApplicationFiled: March 31, 2003Publication date: February 5, 2004Applicants: BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM, OKLAHOMA STATE UNIVERSITYInventors: Massoud Motamedi, Nicholas A. Kotov, James P. Wicksted, Rinat Esenaliev