Patents by Inventor Rino Antonio Bit

Rino Antonio Bit has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Benzimidazole derivatives as bromodomain inhibitors
    Patent number: 11053212
    Abstract: Compounds of formula (I) and salts thereof: wherein R1, R2, R3, R4 are defined herein. Compounds of formula (I) and salts thereof have been found to inhibit the binding of the BET family of bromodomain proteins to, for example, acetylated lysine residues and thus may have use in therapy, for example in the treatment of autoimmune and inflammatory diseases, such as rheumatoid arthritis; and cancers.
    Type: Grant
    Filed: August 22, 2019
    Date of Patent: July 6, 2021
    Assignee: GlaxoSmithKline Intellectual Property Development Limited
    Inventors: Rino Antonio Bit, John Alexander Brown, Philip G. Humphreys, Katherine Louise Jones
  • BENZIMIDAZOLE DERIVATIVES AS BROMODOMAIN INHIBITORS
    Publication number: 20200039953
    Abstract: Compounds of formula (I) and salts thereof: wherein R1, R2, R3, R4 are defined herein. Compounds of formula (I) and salts thereof have been found to inhibit the binding of the BET family of bromodomain proteins to, for example, acetylated lysine residues and thus may have use in therapy, for example in the treatment of autoimmune and inflammatory diseases, such as rheumatoid arthritis; and cancers.
    Type: Application
    Filed: August 22, 2019
    Publication date: February 6, 2020
    Inventors: Rino Antonio BIT, John Alexander Brown, Philip G. Humphreys, Katherine Louise Jones
  • Benzimidazole derivatives as bromodomain inhibitors
    Patent number: 10442786
    Abstract: Compounds of formula (I) and salts thereof: wherein R1, R2, R3, R4 are defined herein. Compounds of formula (I) and salts thereof have been found to inhibit the binding of the BET family of bromodomain proteins to, for example, acetylated lysine residues and thus may have use in therapy, for example in the treatment of autoimmune and inflammatory diseases, such as rheumatoid arthritis; and cancers.
    Type: Grant
    Filed: March 17, 2016
    Date of Patent: October 15, 2019
    Assignee: GlaxoSmithKline Intellectual Property Development Limited
    Inventors: Rino Antonio Bit, John Alexander Brown, Philip G. Humphreys, Katherine Louise Jones
  • IMIDAZOLE DERIVATIVES AND THEIR USE IN THE TREATMENT OF AUTOIMMUNE OR INFLAMMATORY DISEASES OR CANCERS
    Publication number: 20190202799
    Abstract: Compounds of formula (I) and salts thereof: wherein R1, R2, R3, a, X1, X2, X3, X4, and X5 are as defined hereinbefore. Compounds of formula (I) and salts thereof have been found to inhibit the binding of the BET family of bromodomain containing proteins to, for example, acetylated lysine residues and thus may have use in therapy, for example in the treatment of autoimmune and inflammatory diseases, such as rheumatoid arthritis; and cancers.
    Type: Application
    Filed: August 31, 2017
    Publication date: July 4, 2019
    Inventors: Andrew BAXTER, Rino Antonio BIT, John Alexander BROWN, David HIRST, Philip HUMPHREYS, Katherine Louise JONES, Vipulkumar Kantibhai PATEL
  • BENZIMIDAZOLE DERIVATIVES AS BROMODOMAIN INHIBITORS
    Publication number: 20180044317
    Abstract: Compounds of formula (I) and salts thereof: wherein R1, R2, R3, R4 are defined herein. Compounds of formula (I) and salts thereof have been found to inhibit the binding of the BET family of bromodomain proteins to, for example, acetylated lysine residues and thus may have use in therapy, for example in the treatment of autoimmune and inflammatory diseases, such as rheumatoid arthritis; and cancers.
    Type: Application
    Filed: March 17, 2016
    Publication date: February 15, 2018
    Inventors: Rino Antonio BIT, John Alexander BROWN, Philip G HUMPHREYS, Katherine Louise JONES
  • Furopyridines as bromodomain inhibitors
    Patent number: 9670221
    Abstract: The present invention relates to novel compounds, pharmaceutical compositions containing such compounds and to their use in therapy.
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: June 6, 2017
    Assignee: GlaxoSmithKline Intellectual Property (No. 2) Limited
    Inventors: Dominique Amans, Paul Bamborough, Michael David Barker, Rino Antonio Bit, John Alexander Brown, Matthew Campbell, Neil Stuart Garton, Matthew J. Lindon, Tracy Jane Shipley, Natalie Hope Theodoulou, Christopher Roland Wellaway, Susan Marie Westaway
  • Thieno[3,2-C]pyridin-4(5H)-ones as BET inhibitors
    Patent number: 9663533
    Abstract: Thienopyridone compounds of formula (I): or a salt thereof, pharmaceutical compositions containing such compounds and their use in therapy, in particular in the treatment of diseases or conditions for which a bromodomain inhibitor is indicated.
    Type: Grant
    Filed: November 12, 2013
    Date of Patent: May 30, 2017
    Assignee: GlaxoSmithKline LLC
    Inventors: Dominique Amans, Paul Bamborough, Rino Antonio Bit, John Alexander Brown, Matthew Campbell, Matthew John Lindon, Tracy Jane Shipley, Natalie Hope Theodoulou, Christopher Roland Wellaway, Susan Marie Westaway
  • THIENO[3,2-C]PYRIDIN-4(5H)-ONES AS BET INHIBITORS
    Publication number: 20160297832
    Abstract: Thienopyridone compounds of formula (I): or a salt thereof, pharmaceutical compositions containing such compounds and their use in therapy, in particular in the treatment of diseases or conditions for which a bromodomain inhibitor is indicated.
    Type: Application
    Filed: November 12, 2013
    Publication date: October 13, 2016
    Inventors: Dominique AMANS, Paul BAMBOROUGH, Rino Antonio BIT, John Alexander BROWN, Matthew CAMPBELL, Matthew John LINDON, Tracy Jane SHIPLEY, Natalie Hope THEODOULOU, Christopher Roland WELLAWAY, Susan Marie WESTAWAY
  • FUROPYRIDINES AS BROMODOMAIN INHIBITORS
    Publication number: 20160016966
    Abstract: The present invention relates to novel compounds, pharmaceutical compositions containing such compounds and to their use in therapy.
    Type: Application
    Filed: March 12, 2014
    Publication date: January 21, 2016
    Inventors: Dominique AMANS, Paul BAMBOROUGH, Michael David BARKER, Rino Antonio BIT, John Alexander BROWN, Matthew CAMPBELL, Neil Stuart GARTON, Matthew J. LINDON, Tracy Jane SHIPLEY, Natalie Hope THEODOULOU, Christopher Roland WELLAWAY, Susan Marie WESTAWAY
  • S1P1 AGONISTS COMPRISING A BICYCLIC N-CONTAINING RING
    Publication number: 20120101083
    Abstract: The present invention relates to novel compounds of formula (I) having S1P1 agonist activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.
    Type: Application
    Filed: June 17, 2010
    Publication date: April 26, 2012
    Applicant: GLAXO GROUP LIMITED
    Inventors: James Matthew Bailey, Rino Antonio Bit, Emmanuel Hubert Demont, Lee Andrew Harrison, Katherine Louise Jones, Christian Alan Paul Smethurst, Jason Witherington
  • Furan Compounds Useful As Ep1 Receptor Antagonists
    Publication number: 20080287430
    Abstract: Compounds of formula (I) or a pharmaceutically acceptable derivative thereof wherein X, Z, R1, R2a, R2b, R3, and Rx are as defined in the specification, a process for the preparation of such compounds, pharmaceutical compositions comprising such compounds and the use of such compounds in medicine.
    Type: Application
    Filed: April 24, 2006
    Publication date: November 20, 2008
    Inventors: Rino Antonio Bit, Gerard Martin Paul Giblin, Adrian Hall, David Nigel Hurst, Ian Reginald Kilford, Tiziana Scoccitti
  • Phenyl compounds
    Patent number: 7446222
    Abstract: Compounds of formula (I) or derivatives thereof: wherein A, B, Z, R1, R2a, R2b, Rx, R8, and R9 are as defined in the specification, a process for the preparation of such compounds, pharmaceutical compositions comprising such compounds and the use of such compounds in medicine.
    Type: Grant
    Filed: October 30, 2003
    Date of Patent: November 4, 2008
    Assignee: Glaxo Group Limited
    Inventors: Rino Antonio Bit, Gerard Martin Paul Giblin, Adrian Hall, David Nigel Hurst, Ian Reginald Kilford, Neil Derek Miller, Tiziana Scoccitti
  • Oxazole and Thiazole Compounds and Their Use in the Treatment of Pge2 Mediated Disorders
    Publication number: 20080207708
    Abstract: Compounds of formula (I) or a pharmaceutically acceptable derivative thereof: wherein X, Z, Y?, Y?, R1, R2a, R2b, and Rx are as defined in the specification, a process for the preparation of such compounds, pharmaceutical compositions comprising such compounds and the use of such compounds in medicine.
    Type: Application
    Filed: April 24, 2006
    Publication date: August 28, 2008
    Applicant: GLAXO GROUP LIMITED
    Inventors: Rino Antonio Bit, Adrian Hall, David Nigel Hurst, Tiziana Scoccitti