Patents by Inventor Rino Rappuoli

Rino Rappuoli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Detoxified mutants of bacterial ADP-ribosylating toxins as parenteral adjuvants
    Publication number: 20060159701
    Abstract: The present invention provides parenteral adjuvants comprising detoxified mutants of bacterial ADP-ribosylating toxins, particularly those from pertussis (PT), cholera (CT), and heat-labile E. coli (LT).
    Type: Application
    Filed: March 2, 2006
    Publication date: July 20, 2006
    Applicant: Chiron Corporation
    Inventors: Gail Barchfeld, Giuseppe Del Giudice, Rino Rappuoli
  • Nontoxic mucosal adjuvant
    Patent number: 7070781
    Abstract: A non-toxic mucosal adjuvant is provided which may be admixed with further antigens to provide a vaccine administrable to mucosal surfaces in organisms including man. Preferably, the non-toxic mucosal adjuvant is a detoxified mutant of a bacterial ADP-ribosylating toxin, optionally comprising one or more amino acid additions, deletions or substitutions.
    Type: Grant
    Filed: January 24, 2003
    Date of Patent: July 4, 2006
    Assignee: Chiron SRL
    Inventor: Rino Rappuoli
  • Detoxified mutants of bacterial ADP-ribosylating toxins as parenteral adjuvants
    Patent number: 7056521
    Abstract: The present invention provides parenteral adjuvants comprising detoxified mutants of bacterial ADP-ribosylating toxins, particularly those from pertussis (PT), cholera (CT), and heat-labile E. coli (LT).
    Type: Grant
    Filed: August 26, 2004
    Date of Patent: June 6, 2006
    Assignee: Chiron Corporation
    Inventors: Gail Barchfeld, Giuseppe Del Giudice, Rino Rappuoli
  • Adp-ribosylating bacterial toxins
    Publication number: 20060057155
    Abstract: ADP-ribosylating toxins from Neisseria meningitidis, Streptomyces coelicolor, Mycoplasma pneumoniae, Salmonella typhimurium Salmonella paratyphi, and Streptococcus pyogenes are disclosed, together with mutant toxins and uses therefor. There is only a low level of sequence identity between these toxins and toxins such as cholera toxin and E. coli heat labile toxin.
    Type: Application
    Filed: March 28, 2002
    Publication date: March 16, 2006
    Inventors: Vega Masignani, Mariagrazis Pizza, Rino Rappuoli
  • Meningococcal antigens
    Publication number: 20050287165
    Abstract: The invention provides proteins from Neisseria meningitidis (strains A & B), including amino acid sequences, the corresponding nucleotide sequences, expression data, and serological data. The proteins are useful antigens for vaccines, immunogenic compositions, and/or diagnostics.
    Type: Application
    Filed: August 24, 2005
    Publication date: December 29, 2005
    Applicant: Chiron Corporation
    Inventors: Vincenzo Scarlato, Vega Masignani, Rino Rappuoli, Mariagrazia Pizza, Guido Grandi
  • Immunologically active peptides with altered toxicity useful for the preparation of antipertussis vaccine
    Publication number: 20050281837
    Abstract: Immunologically active polypeptides with no or reduced toxicity useful for the preparation of an antipertussis vaccine. Method for the preparation of said polypeptides which comprises, cultivating a microorganisms transformed with a hybrid plasmid including the gene/s which codes for at least one of said polypeptides in a suitable medium and recovering the desired polypeptide from the cells or from the culture medium.
    Type: Application
    Filed: January 29, 2004
    Publication date: December 22, 2005
    Applicant: Chiron S.r.l.
    Inventors: Mariagrazia Pizza, Antonella Bartoloni, Rino Rappuoli
  • Helicobacter pylori CAI antigen
    Publication number: 20050276819
    Abstract: This invention provides polynucleotides encoding Helicobacter pylori cytotoxin associated immunodominant antigen. The polynucleotides can be used as probes to identify the presence of complementary target nucleotide sequences. The invention also provides kits and vectors containing the polynucleotides of the invention.
    Type: Application
    Filed: July 8, 2003
    Publication date: December 15, 2005
    Inventors: Antonio Covacci, Massimo Bugnoli, John Telford, Giovanni Macchia, Rino Rappuoli
  • Combination Neisserial compositions
    Publication number: 20050244436
    Abstract: Compositions comprising a first biological molecule from a Neisseria bacterium and a second biological molecule from a Neisseria bacterium. The term “biological molecule” includes proteins and nucleic acids. Preferred Neisseria species are N.meningitidis and N.gonorrhoeae.
    Type: Application
    Filed: November 9, 2004
    Publication date: November 3, 2005
    Inventors: Marzia Giuliani, Mariagrazia Pizza, Rino Rappuoli
  • Neisseria genomic sequences and methods of their use
    Publication number: 20050191316
    Abstract: The invention provides methods of obtaining immunogenic proteins from genomic sequences including Neisseria, including the amino acid sequences and the corresponding nucleotide sequences, as well as the genomic sequence of Neisseria meningitidis B. The proteins so obtained are useful antigens for vaccines, immunogenic compositions, and/or diagnostics.
    Type: Application
    Filed: August 11, 2004
    Publication date: September 1, 2005
    Inventors: Claire Fraser, Erin Hickey, Jeremy Peterson, Herve Tettelin, Craig Venter, Vega Masignani, Cesira Galeotti, Marirosa Mora, Giulio Ratti, Maria Scarselli, Vincenzo Scarlato, Rino Rappuoli, Mariagrazia Pizza, Guido Grandi
  • Neisserial antigens
    Patent number: 6914131
    Abstract: The invention provides proteins from Neisseria meningitidis (strains A & B) and from Neisseria gonorrhoeae, including amino acid sequences, the corresponding nucleotide sequences, expression data, and serological data. The proteins are useful antigens for vaccines, immunogenic compositions, and/or diagnostics.
    Type: Grant
    Filed: April 30, 1999
    Date of Patent: July 5, 2005
    Assignee: Chiron S.r.l.
    Inventors: Vincenzo Scarlato, Vega Masignani, Rino Rappuoli, Mariagrazia Pizza, Guido Grandi
  • Immunogenic detoxified mutants of cholera toxin
    Publication number: 20050136076
    Abstract: An immunogenic detoxified protein comprising the amino acid sequence of subunit A of a cholera toxin (CT-A) or a fragment thereof or the amino acid sequence of subunit A of an Escherichia coli heat labile toxin (LT-A) or a fragment thereof wherein the amino acids at, or in positions corresponding to Ser-63 and Arg-192 are replaced with another amino acid. The immunogenic detoxified protein is useful as vaccine for Vibrio cholerae or an enterotoxigenic strain of Escherichia coli and is produced by recombinant DNA means by site-directed mutagenesis.
    Type: Application
    Filed: November 12, 2004
    Publication date: June 23, 2005
    Inventors: Mariagrazia Pizza, Maria Fontana, Valentina Giannelli, Rino Rappuoli
  • Detoxified mutants of bacterial ADP-ribosylating toxins as parenteral adjuvants
    Publication number: 20050106180
    Abstract: The present invention provides parenteral adjuvants comprising detoxified mutants of bacterial ADP- ribosylating toxins, particularly those from pertussis (PT), cholera (CT), and heat-labile E. coli (LT).
    Type: Application
    Filed: August 26, 2004
    Publication date: May 19, 2005
    Inventors: Gail Barchfeld, Giuseppe Giudice, Rino Rappuoli
  • Culture medium with yeast or soy bean extract as amino acid source and no protein complexes of animal origin
    Publication number: 20050089968
    Abstract: The present invention relates to a medium containing non-animal derived proteinaceous material for cultivating patheogenic bacteria to produce an immunogenic factor and processes employing such medium.
    Type: Application
    Filed: November 3, 2004
    Publication date: April 28, 2005
    Applicant: Chiron S.p.A.
    Inventors: Roberto Olivieri, Fabio Sabbatini, Maria Kontakou, Lucia Tagliaferri, Antonella Giglioli, Rino Rappuoli
  • Compositions comprising neisseria meningitidis antigens from serogroups b and c
    Publication number: 20050074450
    Abstract: International patent application WO99/61053 discloses immunogenic compositions that comprise N. meningitidis serogroup C oligosaccharide conjugated to a carrier, in combination with N. meningitidis serogroup B outer membrane protein. These are disclosed in the present application in combination with further Neisserial proteins and/or protective antigens against other pathogenic organisms (e.g. Haemophilus influenzae, DTP, HBV, etc.).
    Type: Application
    Filed: November 29, 2000
    Publication date: April 7, 2005
    Inventors: Marzia Giuliani, Mariagrazia Pizza, Rino Rappuoli
  • Polyepitope carrier protein
    Patent number: 6855321
    Abstract: The invention relates to polyepitope carrier proteins that comprise at least five CD4+ T cell epitopes, for conjugation to capsular polysaccharides. The carrier proteins are use useful as components of vaccines that can elicit a T-cell dependent immune response. These vaccines arm particularly useful to confer protection against infection from encapsulated bacteria in infants between the ages of 3 months and about 2 years.
    Type: Grant
    Filed: April 27, 1999
    Date of Patent: February 15, 2005
    Assignee: Chiron S.r.l.
    Inventors: Rino Rappuoli, Guido Grandi
  • Immunization against and treatment for infection by H. pylori
    Patent number: 6841155
    Abstract: Methods for treating and/or protecting H. pylori infection are described. The methods utilize non-mucosal administration of an effective amount of one or more H. pylori antigens.
    Type: Grant
    Filed: April 30, 1999
    Date of Patent: January 11, 2005
    Assignee: Chiron S.r.l.
    Inventors: Guiseppe Del Giudice, Rino Rappuoli
  • Outer membrane vesicle (omv) vaccine comprising n. meningitidis serogroup b outer membrane proteins
    Publication number: 20040249125
    Abstract: A composition comprising (a) Neisseria meningitidis serogroup B outer membrane vesicles (OMVs), and (b) an immunogenic component selected from other Neisseria proteins, or immunogenic fragments thereof. Component (b) preferably includes a protein from a different NmB strain from that from which the OMV of component (a) is derived. The OMVs are preferably obtained by deoxycholate extraction. Optionally, the composition may also comprise a protective antigen against other pathogens.
    Type: Application
    Filed: March 31, 2003
    Publication date: December 9, 2004
    Inventors: Mariagrazia Pizza, Rino Rappuoli, Marzia Monica Giuliani
  • Detoxified mutants of bacterial ADP-ribosylating toxins as parenteral adjuvants
    Patent number: 6818222
    Abstract: The present invention provides parenteral adjuvants comprising detoxified mutants of bacterial ADP-ribosylating toxins, particularly those from pertussis (PT), cholera (CT), and heat-labile E. coli (LT).
    Type: Grant
    Filed: March 18, 1998
    Date of Patent: November 16, 2004
    Assignee: Chiron Corporation
    Inventors: Gail Barchfeld, Giuseppe Del Giudice, Rino Rappuoli
  • Immunogenic detoxified mutants of cholera toxin
    Publication number: 20040137017
    Abstract: An immunogenic detoxified protein comprising the amino acid sequence of subunit A of a cholera toxin (CT-A) or a fragment thereof or the amino acid sequence of subunit A of an Escherichia coli heat labile toxin (LT-A) or a fragment thereof wherein the amino acids at, or in positions corresponding to Ser-63 and Arg-192 are replaced with another amino acid. The immunogenic detoxified protein is useful as vaccine for Vibrio cholerae or an enterotoxigenic strain of Escherichia coli and is produced by recombinant DNA means by site-directed mutagenesis.
    Type: Application
    Filed: June 30, 2003
    Publication date: July 15, 2004
    Applicant: Chiron S.p.A.
    Inventors: Mariagrazia Pizza, Maria Rita Fontana, Valentina Giannelli, Rino Rappuoli
  • Meningococcal antigens
    Publication number: 20040126391
    Abstract: The invention provides proteins from Neissena meningitidis (strains A & B), including amino acid sequences, the corresponding nucleotide sequences, expression data, and serological data. The proteins are useful antigens for vaccines, immunogenic compositions, and/or diagnostics.
    Type: Application
    Filed: October 28, 2003
    Publication date: July 1, 2004
    Applicant: Chiron S.P.A.
    Inventors: Vincenzo Scarlato, Vega Masignani, Rino Rappuoli, Mariagrazia Pizza, Guido Grandi