Patents by Inventor Rintze M. Zelle

Rintze M. Zelle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Regulation of the RAS/cAMP/PKA signaling pathway in yeasts for obtaining a fermentation product during fermentation
    Patent number: 11667680
    Abstract: The present disclosure relates to the modulation in the RAS/cAMP/PKA signaling pathway for maintaining the propagation efficiency and increasing fermentation efficiency of yeast cells. The present disclosure provides yeast cells having or engineered to exhibit a modulation in signaling in a RAS/cAMP/PKA pathway, depending on conditions. For example the yeast cells can be selected or genetically modified to express a mutated Ras1 protein, a mutated Ras2 protein, a mutated Ira1 protein and/or a mutated Ira2 protein, optionally in combination with specific promoters. Also provided herewith are methods for propagating the yeast cells as well as using the yeast cells to generate a fermented product (such as ethanol).
    Type: Grant
    Filed: March 17, 2017
    Date of Patent: June 6, 2023
    Assignee: Lallemand Hungary Liquidity Management LLC
    Inventors: Michelle Oeser, Brooks Henningsen, Janet Fisher, Charles F. Rice, Allan Froehlich, Aaron Argyros, Rintze M. Zelle
  • Mutations in iron-sulfur cluster proteins that improve xylose utilization
    Patent number: 11306304
    Abstract: There is provided an engineered host cells comprising (a) one or more mutations in one or more endogenous genes encoding a protein associated with iron metabolism; and (b) at least one gene encoding a polypeptide having xylose isomerase activity, and methods of their use thereof.
    Type: Grant
    Filed: September 18, 2019
    Date of Patent: April 19, 2022
    Assignee: Lallemand Hungary Liquidity Management LLC
    Inventors: Allan Froehlich, Brooks Henningsen, Sean Covalla, Rintze M. Zelle
  • MUTATIONS IN IRON-SULFUR CLUSTER PROTEINS THAT IMPROVE XYLOSE UTILIZATION
    Publication number: 20200115697
    Abstract: There is provided an engineered host cells comprising (a) one or more mutations in one or more endogenous genes encoding a protein associated with iron metabolism; and (b) at least one gene encoding a polypeptide having xylose isomerase activity, and methods of their use thereof.
    Type: Application
    Filed: September 18, 2019
    Publication date: April 16, 2020
    Inventors: Allan Froehlich, Brooks Henningsen, Sean Covalla, Rintze M. Zelle
  • Mutations in iron-sulfur cluster proteins that improve xylose utilization
    Patent number: 10465181
    Abstract: There is provided an engineered host cells comprising (a) one or more mutations in one or more endogenous genes encoding a protein associated with iron metabolism; and (b) at least one gene encoding a polypeptide having xylose isomerase activity, and methods of their use thereof.
    Type: Grant
    Filed: January 31, 2018
    Date of Patent: November 5, 2019
    Assignee: Lallemand Hungary Liquidity Management LLC
    Inventors: Allan Froehlich, Brooks Henningsen, Sean Covalla, Rintze M. Zelle
  • REGULATION OF THE RAS/CAMP/PKA SIGNALING PATHWAY IN YEASTS
    Publication number: 20190106464
    Abstract: The present disclosure relates to the modulation in the RAS/cAMP/PKA signaling pathway for maintaining the propagation efficiency and increasing fermentation efficiency of yeast cells. The present disclosure provides yeast cells having or engineered to exhibit a modulation in signaling in a RAS/cAMP/PKA pathway, depending on conditions. For example the yeast cells can be selected or genetically modified to express a mutated Ras1 protein, a mutated Ras2 protein, a mutated Ira1 protein and/or a mutated Ira2 protein, optionally in combination with specific promoters. Also provided herewith are methods for propagating the yeast cells as well as using the yeast cells to generate a fermented product (such as ethanol).
    Type: Application
    Filed: March 17, 2017
    Publication date: April 11, 2019
    Inventors: Michelle Oeser, Brooks Henningsen, Janet Fisher, Charles F. Rice, Allan Froehlich, Aaron Argyros, Rintze M. Zelle
  • MUTATIONS IN IRON-SULFUR CLUSTER PROTEINS THAT IMPROVE XYLOSE UTILIZATION
    Publication number: 20180251750
    Abstract: There is provided an engineered host cells comprising (a) one or more mutations in one or more endogenous genes encoding a protein associated with iron metabolism; and (b) at least one gene encoding a polypeptide having xylose isomerase activity, and methods of their use thereof.
    Type: Application
    Filed: January 31, 2018
    Publication date: September 6, 2018
    Inventors: Allan Froehlich, Brooks Henningsen, Sean Covalla, Rintze M. Zelle
  • Mutations in iron-sulfur cluster proteins that improve xylose utilization
    Patent number: 9920312
    Abstract: There is provided an engineered host cells comprising (a) one or more mutations in one or more endogenous genes encoding a protein associated with iron metabolism; and (b) at least one gene encoding a polypeptide having xylose isomerase activity, and methods of their use thereof.
    Type: Grant
    Filed: August 10, 2015
    Date of Patent: March 20, 2018
    Assignee: Lallemand Hungary Liquidity Management LLC
    Inventors: Allan Froehlich, Brooks Henningsen, Sean Covalla, Rintze M. Zelle