Patents by Inventor Rintze Zelle

Rintze Zelle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Acetate toxicity tolerance in recombinant microbial host cells
    Patent number: 11739338
    Abstract: Acetate is a potent microbial inhibitor which can affect the performance of yeast in ethanolic fermentation. The present disclosure provides a recombinant microbial host cell having (i) a first genetic modification for increasing the activity of one or more proteins that function in a first metabolic pathway to convert acetate into an alcohol in the microbial host cell; (ii) a second genetic modification for increasing the activity of one or more proteins that function in a second metabolic pathway to import glycerol in the recombinant microbial host cell (iii) a third genetic modification for increasing the activity of one or more proteins that function in a third metabolic pathway to convert a C5 carbohydrate into ethanol in the microbial host cell. The recombinant microbial host cell comprises and natively expresses native proteins that function in a fourth native metabolic pathway to produce glycerol in the microbial host cell.
    Type: Grant
    Filed: September 18, 2018
    Date of Patent: August 29, 2023
    Assignee: LALLEMAND HUNGARY LIQUIDITY MANAGEMENT LLC
    Inventors: Brooks Henningsen, Sean Covalla, Rintze Zelle, Allan Froehlich
  • ACETATE TOXICITY TOLERANCE IN RECOMBINANT MICROBIAL HOST CELLS
    Publication number: 20210155944
    Abstract: Acetate is a potent microbial inhibitor which can affect the performance of yeast in ethanolic fermentation. The present disclosure provides a recombinant microbial host cell having (i) a first genetic modification for increasing the activity of one or more proteins that function in a first metabolic pathway to convert acetate into an alcohol in the microbial host cell; (ii) a second genetic modification for increasing the activity of one or more proteins that function in a second metabolic pathway to import glycerol in the recombinant microbial host cell (iii) a third genetic modification for increasing the activity of one or more proteins that function in a third metabolic pathway to convert a C5 carbohydrate into ethanol in the microbial host cell. The recombinant microbial host cell comprises and natively expresses native proteins that function in a fourth native metabolic pathway to produce glycerol in the microbial host cell.
    Type: Application
    Filed: September 18, 2018
    Publication date: May 27, 2021
    Inventors: Brooks Henningsen, Sean Covalla, Rintze Zelle, Allan Froehlich