Patents by Inventor Risako ONODERA

Risako ONODERA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BRAIN-PENETRATING LIGAND AND DRUG CARRIER
    Publication number: 20220072150
    Abstract: An exemplary substance is provided that permeates the blood-brain barrier and shows a property of penetrating into the brain. Further, exemplary use of the substance as a drug carrier is provided for delivering into the brain, and a pharmaceutical composition containing the substance. Additionally, exemplary lactose-modified cyclodextrin or dendrimer/glucuronyl glucosyl-cyclodextrin is provided that permeates the blood-brain barrier and shows a property of penetrating into the brain. Exemplary blood-brain barrier permeable pharmaceutical composition is also provided which comprises a lactose-modified cyclodextrin or dendrimer/glucuronyl glucosyl-cyclodextrin, and a drug.
    Type: Application
    Filed: December 27, 2019
    Publication date: March 10, 2022
    Inventors: Hidetoshi ARIMA, Keiichi MOTOYAMA, Taishi HIGASHI, Risako ONODERA, Ryoma YOKOYAMA
  • Composition stably containing single-stranded nucleic acid molecule that suppresses expression of TGF-?1 gene
    Patent number: 10751426
    Abstract: The present invention provides a composition containing a single-stranded nucleic acid molecule consisting of a nucleotide sequence shown by 5?-AGCAGAGUACACACAGCAUAUACC-P-GGUAUAUGCUGUGUGUACUCUGCUUC-P-G-3? (SEQ ID NO: 1) (in the sequence, P is a proline derivative linker represented by (I) in the DESCRIPTION) and a buffer, and having the following features: (a) being in the form of a solution at ambient temperature; and (b) a content of the nucleic acid molecule after storage at 25° C., relative humidity 60% for 4 weeks, of not less than 80% relative to the content at the time of start of the storage.
    Type: Grant
    Filed: October 28, 2016
    Date of Patent: August 25, 2020
    Assignees: BONAC CORPORATION
    Inventors: Taimu Yamada, Hidekazu Toyofuku, Kohei Tahara, Risako Onodera, Hirofumi Takeuchi
  • COMPOSITION STABLY CONTAINING SINGLE-STRANDED NUCLEIC ACID MOLECULE THAT SUPPRESSES EXPRESSION OF TGF-BETA1 GENE
    Publication number: 20180339064
    Abstract: The present invention provides a composition containing a single-stranded nucleic acid molecule consisting of a nucleotide sequence shown by 5?-AGCAGAGUACACACAGCAUAUACC-P-GGUAUAUGCUGUGUGUACUCUGCUUC-P-G-3? (SEQ ID NO: 1) (in the sequence, P is a proline derivative linker represented by (I) in the DESCRIPTION) and a buffer, and having the following features: (a) being in the form of a solution at ambient temperature; and (b) a content of the nucleic acid molecule after storage at 25° C., relative humidity 60% for 4 weeks, of not less than 80% relative to the content at the time of start of the storage.
    Type: Application
    Filed: October 28, 2016
    Publication date: November 29, 2018
    Applicants: BONAC CORPORATION
    Inventors: Taimu YAMADA, Hidekazu TOYOFUKU, Kohei TAHARA, Risako ONODERA, Hirofumi TAKEUCHI
  • THERAPEUTIC AGENT FOR EYE DISEASE
    Publication number: 20180099004
    Abstract: The present invention provides a single stranded nucleic acid molecule represented by the following formula (I): (I) (SEQ?ID?NO:?1) 5?-uagcaccauuugaaaucaguguucc-P- ggaacacugauuucaaauggugcuauu-3? wherein —P— shows a proline derivative linker represented by the following formula (Ia): an agent for treating corneal diseases such as ocular surface disorders and the like, comprising the single stranded nucleic acid molecule as an active ingredient.
    Type: Application
    Filed: April 15, 2016
    Publication date: April 12, 2018
    Applicants: THE UNIVERSITY OF TOKYO, TOKYO MEDICAL UNIVERSITY, BONAC CORPORATION
    Inventors: Hirofumi TAKEUCHI, Tomohiko USUI, Masahiko KURODA, Masakatsu TAKANASHI, Shinichiro OHNO, Hidekazu TOYOFUKU, Kohei TAHARA, Risako ONODERA