Patents by Inventor Rishi Bhatt

Rishi Bhatt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of assessing amyloid-beta peptides in the central nervous system by blood-brain barrier permeable peptide compositions comprising a vab domain of a camelid single domain heavy chain antibody against an anti-amyloid-beta peptide
    Patent number: 10112988
    Abstract: Blood-brain barrier permeable peptide compositions that contain variable antigen binding domains from camelid and/or shark heavy-chain only single-domain antibodies are described. The variable antigen binding domains of the peptide compositions bind to therapeutic and diagnostic biomarkers in the central nervous system, such as the amyloid-beta peptide biomarker for Alzheimer's disease. The peptide compositions contain constant domains from human IgG, camelid IgG, and/or shark IgNAR. The peptide compositions include heavy-chain only single-domain antibodies and compositions with one or more variable antigen binding domain bound to one or more constant domains.
    Type: Grant
    Filed: June 13, 2013
    Date of Patent: October 30, 2018
    Assignee: ICB INTERNATIONAL, INC.
    Inventors: Ram S. Bhatt, Rishi Bhatt
  • Blood-brain barrier permeable peptide compositions comprising a vab domain of a camelid single domain heavy chain antibody against an amyloid-beta peptide
    Patent number: 10112987
    Abstract: Blood-brain barrier permeable peptide compositions that contain variable antigen binding domains from camelid and/or shark heavy-chain only single-domain antibodies are described. The variable antigen binding domains of the peptide compositions bind to therapeutic and diagnostic biomarkers in the central nervous system, such as the amyloid-beta peptide biomarker for Alzheimer's disease. The peptide compositions contain constant domains from human IgG, camelid IgG, and/or shark IgNAR. The peptide compositions include heavy-chain only single-domain antibodies and compositions with one or more variable antigen binding domain bound to one or more constant domains.
    Type: Grant
    Filed: January 8, 2013
    Date of Patent: October 30, 2018
    Assignee: ICB INTERNATIONAL, INC.
    Inventors: Ram S. Bhatt, Rishi Bhatt
  • METHODS FOR USING ANTIBODIES AND ANALOGS THEREOF
    Publication number: 20180238902
    Abstract: Camelid and shark single-domain heavy chain antibodies lacking the light chains, and their analogs are disclosed. Methods for using the antibodies and their analogs to detect antigens are disclosed. Methods to derivatize such antibodies and analogs to develop diagnostic assays are described. Also provided are kits, and methods of using such diagnostics assays.
    Type: Application
    Filed: November 7, 2017
    Publication date: August 23, 2018
    Inventors: Ram S. Bhatt, Rishi Bhatt
  • BLOOD-BRAIN BARRIER PERMEABLE PEPTIDE COMPOSITIONS
    Publication number: 20140193834
    Abstract: Blood-brain barrier permeable peptide compositions that contain variable antigen binding domains from camelid and/or shark heavy-chain only single-domain antibodies are described. The variable antigen binding domains of the peptide compositions bind to therapeutic and diagnostic biomarkers in the central nervous system, such as the amyloid-beta peptide biomarker for Alzheimer's disease. The peptide compositions contain constant domains from human IgG, camelid IgG, and/or shark IgNAR. The peptide compositions include heavy-chain only single-domain antibodies and compositions with one or more variable antigen binding domain, bound to one or more constant domains.
    Type: Application
    Filed: June 13, 2013
    Publication date: July 10, 2014
    Applicant: ICB International, Inc.
    Inventors: Ram S. Bhatt, Rishi Bhatt
  • METHODS FOR USING ANTIBODIES AND ANALOGS THEREOF
    Publication number: 20100136584
    Abstract: Camelid and shark single-domain heavy chain antibodies lacking the light chains, and their analogs are disclosed. Methods for using the antibodies and their analogs to detect antigens are disclosed. Methods to derivatize such antibodies and analogs to develop diagnostic assays are described. Also provided are kits, and methods of using such diagnostics assays.
    Type: Application
    Filed: October 27, 2009
    Publication date: June 3, 2010
    Inventors: Ram S. Bhatt, Rishi Bhatt