Abstract: The present disclosure provides cocrystals of an active pharmaceutical ingredient and a co-former. The co-former may be either an excipient or a second active pharmaceutical ingredient. These particular co-crystals may be made through either an extension based process or a solvent based method. These cocrystals may be used in additive manufacturing processes. These pharmaceutical compositions may be used in the treatment of a disease or disorder.

Abstract: The present disclosure provides methods of preparing pharmaceutical compositions using an additive manufacturing technique containing cocrystals. The cocrystals used in these compositions may be formed using an active pharmaceutical ingredient and a co-former. The co-former may be either an excipient or a second active pharmaceutical ingredient. These pharmaceutical compositions may be used in the treatment of a disease or disorder.

Abstract: The present disclosure provides pharmaceutical compositions prepared using an additive manufacturing process where the active pharmaceutical ingredient has been rendered into the amorphous form or prepared as an amorphous solid dispersion at a temperature below the melting point of the active pharmaceutical ingredient or the glass transition of the physical mixture or composition of the individual components. The present disclosure also provides methods of preparing these compositions by using properties such as the chamber and surface temperature and the electron laser density.

Abstract: The present disclosure provides pharmaceutical compositions which exhibit improved flowability as measured by the angle of repose. The pharmaceutical compositions comprise an active pharmaceutical ingredient, two or more absorbents, and optionally surfactant. These pharmaceutical compositions may be used in the manufacturing of pharmaceutical dosage forms or an additive manufacturing process such as 3D selective laser sintering printing.