Patents by Inventor Rita Barresi

Rita Barresi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Increasing functional glycosylation of alpha-dystroglycan in the treatment of muscle degeneration
    Patent number: 8119766
    Abstract: Disclosed is a method for the prevention and/or treatment of muscle degeneration. In this method, a subject recognized as having muscle degeneration is treated with a composition effective to increase functional glycosylation of ?-dystroglycan in an affected tissue in the subject. Functional glycosylation is to be increased to an extent wherein the binding of ?-dystroglycan to its ligands in the affected tissue is rescued to levels substantially similar to those in an evenly matched tissue unaffected by degeneration. One effective means for increasing functional glycosylation of ?-dystroglycan in a subject includes increasing glycosyltransferase activity, such as LARGE or LARGE2 activity, in the muscle of the subject. Therapeutic glycosylated peptide compositions are also provided.
    Type: Grant
    Filed: June 2, 2005
    Date of Patent: February 21, 2012
    Assignee: University of Iowa Research Foundation
    Inventors: Kevin P. Campbell, Rita Barresi
  • Increasing functional glycosylation of alpha-dystroglycan in the treatment of muscle degeneration
    Publication number: 20060276376
    Abstract: Disclosed is a method for the prevention and/or treatment of muscle degeneration. In this method, a subject recognized as having muscle degeneration is treated with a composition effective to increase functional glycosylation of ?-dystroglycan in an affected tissue in the subject. Functional glycosylation is to be increased to an extent wherein the binding of ?-dystroglycan to its ligands in the affected tissue is rescued to levels substantially similar to those in an evenly matched tissue unaffected by degeneration. One effective means for increasing functional glycosylation of ?-dystroglycan in a subject includes increasing glycosyltransferase activity, such as LARGE or LARGE2 activity, in the muscle of the subject. Therapeutic glycosylated peptide compositions are also provided.
    Type: Application
    Filed: June 2, 2005
    Publication date: December 7, 2006
    Inventors: Kevin Campbell, Rita Barresi