Abstract: HIV-1 Env ectodomain trimers stabilized in a prefusion mature closed conformation and methods of their use and production are disclosed. In several embodiments, the HIV-1 Env ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to HIV-1 in a subject. In additional embodiments, the therapeutically effective amount of the HIV-1 Env ectodomain trimers can be administered to a subject in a method of treating or preventing HIV-1 infection.

Abstract: HIV-1 Env ectodomain trimers stabilized in a prefusion mature closed conformation and methods of their use and production are disclosed. In several embodiments, the HIV-1 Env ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to HIV-1 in a subject. In additional embodiments, the therapeutically effective amount of the HIV-1 Env ectodomain trimers can be administered to a subject in a method of treating or preventing HIV-1 infection.

Abstract: HIV-1 Env ectodomain trimers stabilized in a prefusion mature closed conformation and methods of their use and production are disclosed. In several embodiments, the HIV-1 Env ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to HIV-1 in a subject. In additional embodiments, the therapeutically effective amount of the HIV-1 Env ectodomain trimers can be administered to a subject in a method of treating or preventing HIV-1 infection.

Abstract: Vehicle entertainment systems can determine an entertainment preference of a passenger based on the interactions of the passenger with media devices on board the vehicle. The interactions can include how the passenger rates content, whether the passenger views the entirety of the content, or information regarding the passenger such as frequent flier data. The analysis to determine the preferences of the passenger are done without placing cookies on the passenger's devices and by components on board the vehicle. The analysis can include machine learning techniques that build trained models of passenger preferences. Additionally, the trained models can develop profiles for each passenger. At the end of the travel experience, the preferences of a passenger can be deleted such that a new passenger does not see content that was based on the prior passenger's preferences.

Abstract: Methods, systems, and computer programs are presented for generating location-based playlists. The disclosed method includes providing a music service for generating playlists for a location, identifying users having respective user devices within the defined boundaries of the location, and aggregating music preferences of the identified users. Each of the user devices have access to the music service and the aggregated music preferences of the identified users identify a plurality of music tracks. The disclosed method further includes generating a playlist having the plurality of music tracks based on the aggregated music preferences and providing an access to the generated playlist to the identified users at the location. The plurality of music tracks of the playlist is provided for listening by the music service to one or more of the user devices.

Abstract: Methods, systems, and computer programs are presented for generating location-based playlists. The disclosed method includes providing a music service for generating playlists for a location, identifying users having respective user devices within the defined boundaries of the location, and aggregating music preferences of the identified users. Each of the user devices have access to the music service and the aggregated music preferences of the identified users identify a plurality of music tracks. The disclosed method further includes generating a playlist having the plurality of music tracks based on the aggregated music preferences and providing an access to the generated playlist to the identified users at the location. The plurality of music tracks of the playlist is provided for listening by the music service to one or more of the user devices.

Abstract: Methods, systems, and computer programs are presented for discovering and selecting location-based music. The disclosed method includes identifying a user having a user device, determining a distance zone proximate to the user device, and identifying a group of users having respective nearby devices within the distance zone. Each of the nearby devices is in progress of playing a selected music track. Each of the identified user device and the nearby devices has access to an application for accessing online music. The disclosed method further includes generating a playlist for the user device based on examination of the selected music tracks being played by the users and forwarding the generated playlist to the user device.

Abstract: HIV-1 Env ectodomain trimers stabilized in a prefusion mature closed conformation and methods of their use and production are disclosed. In several embodiments, the HIV-1 Env ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to HIV-1 in a subject. In additional embodiments, the therapeutically effective amount of the HIV-1 Env ectodomain trimers can be administered to a subject in a method of treating or preventing HIV-1 infection.

Abstract: Disclosed are recombinant insect ferritin nanoparticles that can be used to display two different trimeric antigens at an equal ratio. Also disclosed are nucleic acids encoding the recombinant insect ferritin nanoparticles and methods of producing the recombinant insect ferritin nanoparticles. Methods for eliciting an immune response in a subject are also provided.

Abstract: Methods, systems, and computer programs are presented for generating location-based playlists. The disclosed method includes providing a music service for generating playlists for a location, identifying users having respective user devices within the defined boundaries of the location, and aggregating music preferences of the identified users. Each of the user devices have access to the music service and the aggregated music preferences of the identified users identify a plurality of music tracks. The disclosed method further includes generating a playlist having the plurality of music tracks based on the aggregated music preferences and providing an access to the generated playlist to the identified users at the location. The plurality of music tracks of the playlist is provided for listening by the music service to one or more of the user devices.

Abstract: HIV-1 Env ectodomain trimers stabilized in a prefusion mature closed conformation and methods of their use and production are disclosed. In several embodiments, the HIV-1 Env ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to HIV-1 in a subject. In additional embodiments, the therapeutically effective amount of the HIV-1 Env ectodomain trimers can be administered to a subject in a method of treating or preventing HIV-1 infection.

Abstract: HIV-1 Env ectodomain trimers stabilized in a prefusion mature closed conformation and methods of their use and production are disclosed. In several embodiments, the HIV-1 Env ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to HIV-1 in a subject. In additional embodiments, the therapeutically effective amount of the HIV-1 Env ectodomain trimers can be administered to a subject in a method of treating or preventing HIV-1 infection.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for displaying, within a web page, a representation of a content sharing interface, the content sharing interface including a content input area, receiving user input to the content input area, in response to the user input, expanding the content sharing interface to include an expanded content input area and a distribution interface, the expanded content input area displaying a graphical representation of digital content that is to be distributed, receiving user input to the distribution interface, the user input indicating contact(s) to which the digital content is to be distributed, in response to receiving the user input, displaying an icon within the distribution interface, the icon being a graphical representation of the contact(s), and in response to the user input, transmitting a post data set including digital content data and distribution data to a server computing system.

Abstract: Methods, systems, and computer programs are presented for generating location-based playlists. The disclosed method includes providing a music service for generating playlists for a location, identifying users having respective user devices within the defined boundaries of the location, and aggregating music preferences of the identified users. Each of the user devices have access to the music service and the aggregated music preferences of the identified users identify a plurality of music tracks. The disclosed method further includes generating a playlist having the plurality of music tracks based on the aggregated music preferences and providing an access to the generated playlist to the identified users at the location. The plurality of music tracks of the playlist is provided for listening by the music service to one or more of the user devices.

Abstract: An interactive digital map of a geographic area is provided via a user interface of a computing device. A selection of a point on the digital map is received, where the selected point corresponds to a selected location within the geographic area. In response to receiving the selection of the point and without receiving a request for directions from a user via the user interface, an indication of a length of a trip between a current location of the computing device and the selected location is automatically obtained. The indication of the length of the trip along with the interactive digital map are displayed via the user interface.

Abstract: Provided are systems, methods, and computer-readable media for identifying reviews from comments associated with a location. User-submitted comments to various services are evaluated to identify the comment as a review. If the comment is not identified as a review, no further action is taken. If the comment is identified as a review, the user is prompted for permission to publish the comment as a review of the location. If the user provides permission, the comment is stored as a review of the location.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for presenting, within a web page, a graphical representation of a content sharing interface including at least one button icon, receiving user input to the button icon, in response to the user input, expanding the content sharing interface to include an expanded content input area and a distribution interface, the expanded content input area displaying a graphical representation of digital content that is to be distributed, receiving user input to the distribution interface, the user input indicating contact(s) to which the digital content is to be distributed, in response to receiving the user input, displaying icon(s) within the distribution interface, the icon(s) being a graphical representation of the contact(s), and transmitting a post data set including digital content data and distribution data to a server computing system.

Abstract: A system and method for estimating travel time are provided. A general travel time is determined for a first route. A personal travel time for the first route is determined based on travel data of a user while traveling the first route. A scaling factor is determined based on at least one travel characteristic associated with the user or the route. A travel time for is estimated a second route based on the general travel time, the personal travel time and the scaling factor.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for presenting, within a web page, a graphical representation of a content sharing interface including at least one button icon, receiving user input to the button icon, in response to the user input, expanding the content sharing interface to include an expanded content input area and a distribution interface, the expanded content input area displaying a graphical representation of digital content that is to be distributed, receiving user input to the distribution interface, the user input indicating contact(s) to which the digital content is to be distributed, in response to receiving the user input, displaying icon(s) within the distribution interface, the icon(s) being a graphical representation of the contact(s), and transmitting a post data set including digital content data and distribution data to a server computing system.

Abstract: The disclosed subject matter relates to computer-implemented methods for calculating a travel route based on navigational preferences and travel history of a user. In one aspect, a method includes storing the navigational preferences and travel history of the user. The stored navigational preferences include routing preferences and points of interest of the user. The travel history of the user includes location data from a respective date and time received from a location-aware device associated with the user. The method further includes receiving request for a travel route from an origin location to a destination location. The method further includes calculating, in response to the received request, the travel route from the origin location to the destination location, based on the stored navigational preferences and the stored travel history of the user.