Patent number: 7786129
Abstract: The present invention is concerned with new 3,3-disubstituted indol-2-one derivatives of the general Formula (I), wherein R1 stands for hydrogen, halogen, alkyl having 1-7 carbon atom(s) or sulfonamido; R2 represents hydrogen or halogen; R3 denotes hydrogen, alkyl having 1-7 carbon atom(s) optionally carrying an aryl substituent or aryl optionally carrying one or two halogen substituent(s); R4 stands for alkyl having 1-7 carbon atom(s); R5 represents a group of the general Formula (II a) or (II b), wherein Q and W each represents nitrogen or CH; R6, R7 and R8 each stands for hydrogen, halogen, trifluoromethyl, alkyl or alkoxy having 1-7 carbon atom(s), or R6 and R7 together represent ethylenedioxy; m is 0, 1, or 2; a is a single, double or triple bond; n is 0, 1 or 2; and pharmaceutically acceptable acid addition salts thereof which are useful in the treatment or prophylaxis of diseases of the central nervous system, the gastrointestinal system and the cardiovascular system.
Type:
Grant
Filed:
May 11, 2005
Date of Patent:
August 31, 2010
Assignee:
Egis Gyogyszergyar Nyrt
Inventors:
Balázs Volk, József Barkóczy, Gyula Simig, Tibor Mezei, Rita Kapillerné Dezsöfi, Endréné Flórian, István Gacsályi, Katalin Pallagi, Gábor Gigler, György Lévay, Krisztina Móricz, Csilla Leveleki, Nóra Sziray, Gábor Szénási, András Egyed, László Gábor Hársing
