Abstract: In some aspects, the invention teaches pharmaceutical compositions that include a TGF-? ligand trap, and methods of using a TGF-? ligand trap to treat, prevent, or reduce the progression rate of pulmonary hypertension (PH). The invention also provides methods of using a TGF-? ligand trap to treat, prevent, or reduce the progression rate of a variety of conditions including, but not limited to, pulmonary vascular remodeling, pulmonary fibrosis, right ventricular hypertrophy, diseases associated with excessive TGF-? signaling, diseases associated with excessive GDF15 signaling, and diseases associated with excessive PAI-1 signaling. The invention further provides methods of using a TGF-? ligand trap to reduce right ventricular systolic pressure in a subject.

Abstract: The present invention relates to a bacterium strain of accession no. MTCC 5099, a process for the preparation of inoculum of the said strain, and a process for the reduction of color from pulp mill effluent using the above said inoculum, which comprises steps of inoculating appropriate aliquots of the pulp and paper mill effluent with the cell slurry obtained, incubating the mixture at about 37 degree C. at about 100 rpm for time duration ranging between 24-48 hours, assessing color and total lignin levels to determine the color removal efficiency of the above said bacterium.

Abstract: The present invention deals with a device for quick estimation of biochemical oxygen demand of beverage waste water. This device consists of an immobilized microbial membrane attached to an electrode, multimeter and a laptop workstation installed with a developed software. BOD measurement of beverage waste water using this device is rapid, reproducible and effective as compared to conventional titration based methods. This device also excludes COD estimation as required for BOD estimation of waste water. This bio-electrochemical device may find wide commercial application in beverage industries emanating waste waters.

Abstract: The present invention relates to an environment friendly, safe, and efficient four-step method of bio-bleaching Kraft pulp using the following strains of bacteria: (a) Serratia marcescens, MTCC 5094, (b) Pseudomonas aeruginosa, MTCC 5095, (c) Providencia rettgeri, MTCC 5096, (d) Pseudomonas aeruginosa, MTCC 5098. The present invention also provides a microbial consortium comprising a synergistic mixture of ligninolytic bacterial isolates Serratia marcescens, MTCC 5094, Pseudomonas aeruginosa, MTCC 5095, and Pseudomonas aeruginosa, MTCC 5098, or comprising bacterial strains Providencia rettgeri, MTCC 5096, Serratia marcescens, MTCC 5094, Pseudomonas aeruginosa, MTCC 5095, and Pseudomonas aeruginosa, MTCC 5098, and a process for preparing an inoculum of the bacterial isolate Providencia rettgeri, MTCC 5096.

Abstract: The invention relates to a microbial composition for the neutralization of alkaline waste waters by biological means and a method of neutralization of alkaline waste waters using a synergistic mixture of the bacterial strains of Bacillus alkalophilus and Bacillus sp.

Abstract: The present invention relates to a bacterium strain of accession no. MTCC 5099, a process for the preparation of inoculum of the said strain, and a process for the reduction of color from pulp mill effluent using the above said inoculum, which comprises steps of inoculating appropriate aliquots of the pulp and paper mill effluent with the cell slurry obtained, incubating the mixture at about 37 degree C. at about 100 rpm for time duration ranging between 24-48 hours, assessing color and total lignin levels to determine the color removal efficiency of the above said bacterium.

Abstract: The present invention provides a seeding material for accurate and reproducible monitoring of BOD load of pulp and paper wastewater, wherein the bacteria are isolated from various locations in India and comprise Micrococcus sp., Staphylococcus sp., Kurthia zopfii, Alcaligenes faecalis, and Pseudomonas aeruginosa, the microbial composition being capable of exerting an appropriate BOD for pulp and paper industrial wastewater due to the specificity of bacterial strains present therein towards the refractory organic compounds found in these effluents.

Abstract: The present invention provides a process of neutralizing beverage industrial wastewater by a bacterial strain Exiguobacterium sp. isolated in India, which strain is capable of bring down the pH of wastewater from 12.00 to 7.00 units within 1 to 1.5 hours.

Abstract: The invention relates to a microbial composition for the neutralization of alkaline waste waters by biological means and a method of neutralization of alkaline waste waters using a synergistic mixture of the bacterial strains of Bacillus alkalophilus and Bacillus sp.

Abstract: The present invention deals with a device for quick estimation of biochemical oxygen demand of beverage waste water. This device consists of an immobilized microbial membrane attached to an electrode, multimeter and a laptop workstation installed with a developed software. BOD measurement of beverage waste water using this device is rapid, reproducible and effective as compared to conventional titration based methods. This device also excludes COD estimation as required for BOD estimation of waste water. This bio-electrochemical device may find wide commercial application in beverage industries emanating waste waters.

Abstract: The invention provides a biological process for reduction of chemical and biological oxygen demand of pulp and paper industrial effluent using a mixed bacterial consortium comprising of bacterial strains isolated from natural sources which is capable of reducing chemical and biological oxygen demand of pulp and paper industrial effluent to standard discharge limits.

Abstract: The present invention provides a novel process of neutralizing textile industrial wastewater by a bacterial strain isolated in India. The isolated bacterial strain is capable to bring down the pH of wastewater from 12.00 to 7.00 units within two hours. The neutralization of alkaline textile industrial wastewater by such biotechnological process is highly effective and economical as compared to conventional neutralization by chemical means. This biotechnological process may find wide commercial application in textile industries emanating alkaline wastewater.

Abstract: The present invention provides a novel process of neutralizing textile industrial wastewater by a bacterial strain isolated in India. The isolated bacterial strain is capable to bring down the pH of wastewater from 12.00 to 7.00 units within two hours. The neutralization of alkaline textile industrial wastewater by such biotechnological process is highly effective and economical as compared to conventional neutralization by chemical means. This biotechnological process may find wide commercial application in textile industries emanating alkaline wastewater.

Abstract: The present invention provides a seeding material for accurate and reproducible monitoring of BOD load of pulp and paper wastewater, wherein the bacteria are isolated from various locations in India and comprise Micrococcus sp., Staphylococcus sp., Kurthia zopfii, Alcaligenes faecalis, and Pseudomonas aeruginosa, the microbial composition being capable of exerting an appropriate BOD for pulp and paper industrial wastewater due to the specificity of bacterial stows present therein towards the refractory organic compounds found in these effluents.

Abstract: The invention provides a biological process for reduction of chemical and biological oxygen demand of pulp and paper industrial effluent using a mixed bacterial consortium comprising of bacterial strains isolated from natural sources which is capable of reducing chemical and biological oxygen demand of pulp and paper industrial effluent to standard discharge limits.

Abstract: The present invention provides a process of neutralizing beverage industrial wastewater by a bacterial strain Exiguobacterium sp. isolated in India, which strain is capable of bring down the pH of wastewater from 12.00 to 7.00 units within 1 to 1.5 hours.

Abstract: The invention provides a novel process of lignin degradation using a consortium of bacteria. To date, biodegradation of lignin has been centered to fungi only. Degradation of lignin by bacteria confer a new understanding that may be of tremendous industrial significance.

Abstract: The invention provides a novel process of lignin degradation using a consortium of bacteria. To date, biodegradation of lignin has been centered to fungi only. Degradation of lignin by bacteria confer a new understanding that may be of tremendous industrial significance. This invention also discloses the isolation and acclimatization of ligninolytic bacteria from a specific site.

Abstract: The present invention relates to an environment friendly, safe, and efficient four-step method of bio-bleaching Kraft pulp using bacterial strains of accession no. MTCC 5096, MTCC 5094, MTCC 5095, and MTCC 5098, a microbial consortium comprising a synergistic mixture of ligninolytic bacterial isolates of accession no. MTCC 5094, MTCC 5095, and MTCC 5098, bacterial strains of accession Nos. MTCC 5096, MTCC 5094, MTCC 5095, and MTCC 5098, and a process of preparing an inoculum of the bacterial isolate of accession no. MTCC 5096, further, a process for the preparation of a consortium comprising the ligninolytic bacterial isolates of accession nos. MTCC 5094, MTCC 5095, and MTCC 5098, in addition, a process for the preparation of pulp suspension for the bio-bleaching.

Abstract: The present invention relates to an environment friendly, safe, and efficient four-step method of bio-bleaching Kraft pulp using bacterial strains of accession no. MTCC 5096, MTCC 5094, MTCC 5095, and MTCC 5098, a microbial consortium comprising a synergistic mixture of ligninolytic bacterial isolates of accession no. MTCC 5094, MTCC 5095, and MTCC 5098, bacterial strains of accession Nos. MTCC 5096, MTCC 5094, MTCC 5095, and MTCC 5098, and a process of preparing an inoculum of the bacterial isolate of accession no. MTCC 5096, further, a process for the preparation of a consortium comprising the ligninolytic bacterial isolates of accession nos. MTCC 5094, MTCC 5095, and MTCC 5098, in addition, a process for the preparation of pulp suspension for the bio-bleaching.