Abstract: Peptide compositions and methods of producing and using same are provided. The peptide compositions are based on pilin peptides derived from Pseudomonas aeruginosa. The compositions include antigens and antibodies immunoreactive against the antigens. The compositions can be utilized in vaccines for treatment purposes, such as to treat or prevent infection associated with Pseudomonas aeruginosa and/or other infectious agents. Further, the compositions can be utilized to produce antibody or monoclonal antibody therapeutic to treat or prevent infection associated with Pseudomonas aeruginosa and/or other infectious agents.