Patents by Inventor Rita Pfeifer

Rita Pfeifer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ENDOGENOUS SIGNALING MOLECULE ACTIVATING CHIMERIC ANTIGEN RECEPTORS AND METHODS OF GENERATION THEREOF
    Publication number: 20250339464
    Abstract: The present invention provides an endogenous signaling molecule activating chimeric antigen receptor (ESMA-CAR) comprising a) an antigen binding domain specific for an antigen, b) a first transmembrane domain, and c) an intracellular signaling domain comprising a co-stimulatory domain but no stimulatory domain, wherein said first transmembrane domain, when expressed on the cell surface of an immune cell, is able to recruit a stimulatory domain of an endogenous signaling molecule of said immune cell, wherein said endogenous signaling molecule is a protein comprising a second transmembrane domain and an intracellular signaling domain comprising a stimulatory domain, and wherein the interaction of the first transmembrane domain and the second transmembrane domain activates said immune cell upon binding of said antigen to said antigen binding domain of said ESMA-CAR. The present invention also discloses an immune cell expressing said ESMA-CAR and an in-vitro method for the generation of said ESMA-CAR.
    Type: Application
    Filed: May 15, 2023
    Publication date: November 6, 2025
    Applicant: MILTENYI BIOTEC B.V. & CO. KG
    Inventors: Mira Ebbinghaus, Rita Pfeifer
  • Chimeric antigen receptor with a spacer comprising C2-set Ig-like domains
    Patent number: 12286465
    Abstract: Provided herein are chimeric antigen receptors (CARs) that include a) an antigen binding domain specific for an antigen, b) a spacer, c) a transmembrane domain, and d) an intracellular signaling domain, wherein the spacer consists of 1, 2 or 3 C2-set Ig-like domain(s) e.g., C2-set Ig-like domains of the sialic acid binding Ig-like lectin (Siglec) family. Also provided herein are compositions including a) an immune cell expressing a CAR, wherein the CAR is specific for a tag and b) a tagged polypeptide.
    Type: Grant
    Filed: May 27, 2021
    Date of Patent: April 29, 2025
    Assignee: Miltenyi Biotec B.V. & Co. KG
    Inventors: Rita Pfeifer, Daniel Schäfer, Ian Johnston
  • Chimeric antigen receptor with a spacer comprising C2-set Ig-like domains
    Publication number: 20210371490
    Abstract: The present invention provides a CAR comprising a) an antigen binding domain specific for an antigen, b) a spacer, c) a transmembrane domain, and d) an intracellular signaling domain, wherein said spacer consists of 1, 2 or 3 C2-set Ig-like domain(s). Said C2-set Ig-like domain(s) may be selected from the group of C2-set Ig-like domains of the sialic acid binding Ig-like lectin (Siglec) family. A composition comprising a) an immune cell expressing said CAR, wherein said CAR is specific for a tag and b) a tagged polypeptide is also disclosed.
    Type: Application
    Filed: May 27, 2021
    Publication date: December 2, 2021
    Inventors: Rita Pfeifer, Daniel Schäfer, Ian Johnston