Patents by Inventor Rita Scarpelli

Rita Scarpelli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SUBSTITUTED N-HETEROCYCLIC CARBOXAMIDES AS ACID CERAMIDASE INHIBITORS AND THEIR USE AS MEDICAMENTS
    Publication number: 20220402901
    Abstract: The invention provides substituted N-heterocyclic carboxamides and related compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat a medical disorder, e.g., cancer, lysosomal storage disorder, neurodegenerative disorder, inflammatory disorder, in a patient.
    Type: Application
    Filed: September 17, 2020
    Publication date: December 22, 2022
    Inventors: Renato T. Skerlj, Rita Scarpelli, Vincenzo Cilibrasi, Samantha Caputo
  • SUBSTITUTED, SATURATED AND UNSATURATED N-HETEROCYCLIC CARBOXAMIDES AND RELATED COMPOUNDS FOR THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS
    Publication number: 20220380314
    Abstract: The invention provides substituted, saturated and unsaturated N-heterocyclic carboxamides and related compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat medical disorders, e.g., cancer, lysosomal storage disorder, neurodegenerative disorder, inflammatory disorder, in a patient.
    Type: Application
    Filed: September 17, 2020
    Publication date: December 1, 2022
    Inventors: Renato T. Skerlj, Elyse Marie Josee Bourque, Soumya Ray, Rita Scarpelli, Vincenzo Cilibrasi
  • Piperazinyl methanone NAAA inhibitors
    Patent number: 10556892
    Abstract: Disclosed herein, inter alia, are compositions and methods for modulating the activity of N-acylethanolamine acid amidase for the treatment of a pathological state, including pain, an inflammatory condition, or a neurodegenerative disorder.
    Type: Grant
    Filed: May 16, 2017
    Date of Patent: February 11, 2020
    Assignees: The Regents of the University of California, Fondazione Istituto Italiano di Technologia
    Inventors: Daniele Piomelli, Rita Scarpelli, Marco Migliore, Roger Heim, Miguel Garcia-Guzmàn
  • Inhibitors of fatty acid amide hydrolase (FAAH) enzyme with improved oral bioavailability and their use as medicaments
    Patent number: 10435355
    Abstract: Described herein, inter alia, are compositions and methods useful for inhibiting fatty acid amide hydrolase.
    Type: Grant
    Filed: October 13, 2017
    Date of Patent: October 8, 2019
    Assignees: The Regents of the University of California, Fondazione Istituto Italiano di Tecnologia
    Inventors: Daniele Piomelli, Tiziano Bandiera, Rita Scarpelli
  • PIPERZINYL METHANONE NAAA INHIBITORS
    Publication number: 20190177313
    Abstract: Disclosed herein, inter alia, are compositions and methods for modulating the activity of N-acylethanolamine acid amidase for the treatment of a pathological state, including pain, an inflammatory condition, or a neurodegenerative disorder.
    Type: Application
    Filed: May 16, 2017
    Publication date: June 13, 2019
    Inventors: Daniele Piomelli, Rita Scarpelli, Marco Migliore
  • Substituted benzoxazolone derivatives as acid ceramidase inhibitors, and their use as medicaments
    Patent number: 10213416
    Abstract: The present invention relates to substituted benzoxazolone derivatives as acid ceramidase inhibitors, pharmaceutical compositions containing these inhibitors and methods of inhibiting acid ceramidase for the treatment of disorders in which modulation of the levels of ceramide is clinically relevant. The invention also provides substituted benzoxazolone derivatives for use in the treatment of cancer, inflammation, pain, inflammatory pain or pulmonary diseases.
    Type: Grant
    Filed: November 8, 2016
    Date of Patent: February 26, 2019
    Assignees: The Regents of the University of Chicago, Fondazione Istituto Italiano di Technologia
    Inventors: Daniele Piomelli, Daniela Pizzirani, Anders Bach, Rita Scarpelli, Laurin Melzig, Marco Mor
  • INHIBITORS OF FATTY ACID AMIDE HYDROLASE (FAAH) ENZYME WITH IMPROVED ORAL BIOAVAILABILITY AND THEIR USE AS MEDICAMENTS
    Publication number: 20180194722
    Abstract: Described herein, inter alia, are compositions and methods useful for inhibiting fatty acid amide hydrolase.
    Type: Application
    Filed: October 13, 2017
    Publication date: July 12, 2018
    Inventors: Daniele PIOMELLI, Tiziano Bandiera, Rita Scarpelli
  • Dual inhibitor compounds for use in the treatment of neurodegenerative disorders and alzheimer's disease
    Patent number: 9975861
    Abstract: The present invention relates to Compounds of Formula (I) and pharmaceutical compositions containing the same. It further relates to their use in the prevention or treatment of central nervous system diseases or disorders, in particular, cognitive, neurodegenerative or neuronal diseases or disorders.
    Type: Grant
    Filed: June 12, 2015
    Date of Patent: May 22, 2018
    Assignees: FONDAZIONE ISTITUTO ITAIANO DI TECNOLOGIA, ALMA MATER STUDIORUM—UNIVERSITA'DI BOLOGNA
    Inventors: Andrea Cavalli, Federica Prati, Giovanni Bottegoni, Angelo Danilo Favia, Daniela Pizzirani, Rita Scarpelli, Maria Laura Bolognesi
  • Diarylalkylamine REV-ERB antagonists and their use as medicaments
    Patent number: 9949968
    Abstract: The present invention relates to compounds of Formula (I) or pharmaceutically acceptable salts or solvates thereof: It further discloses a pharmaceutical composition comprising the compounds of Formula (I) and their uses as anti-proliferative and proapoptotic agents for cancer therapy.
    Type: Grant
    Filed: November 22, 2016
    Date of Patent: April 24, 2018
    Assignee: Fondazione Istituto Italiano Di Tecnologia
    Inventors: Benedetto Grimaldi, Esther Torrente, Rita Scarpelli, Giovanni Bottegoni, Tiziano Bandiera, Marina Veronesi
  • Inhibitors of fatty acid amide hydrolase (FAAH) enzyme with improved oral bioavailability and their use as medicaments
    Patent number: 9822068
    Abstract: Described herein, inter alia, are compositions and methods useful for inhibiting fatty acid amide hydrolase.
    Type: Grant
    Filed: October 6, 2016
    Date of Patent: November 21, 2017
    Assignees: The Regents of the University of California, Fondazione Istituto Italiano di Technologia
    Inventors: Daniele Piomelli, Tiziano Bandiera, Rita Scarpelli
  • SUBSTITUTED BENZOXAZOLONE DERIVATIVES AS ACID CERAMIDASE INHIBITORS, AND THEIR USE AS MEDICAMENTS
    Publication number: 20170182009
    Abstract: The present invention relates to substituted benzoxazolone derivatives as acid ceramidase inhibitors, pharmaceutical compositions containing these inhibitors and methods of inhibiting acid ceramidase for the treatment of disorders in which modulation of the levels of ceramide is clinically relevant. The invention also provides substituted benzoxazolone derivatives for use in the treatment of cancer, inflammation, pain, inflammatory pain or pulmonary diseases.
    Type: Application
    Filed: November 8, 2016
    Publication date: June 29, 2017
    Inventors: Daniele PIOMELLI, Daniela PIZZIRANI, Anders BACH, Rita SCARPELLI, Laurin MELZIG, Marco MOR
  • DIARYLALKYLAMINE REV-ERB ANTAGONISTS AND THEIR USE AS MEDICAMENTS
    Publication number: 20170136009
    Abstract: The present invention relates to compounds of Formula (I) or pharmaceutically acceptable salts or solvates thereof: It further discloses a pharmaceutical composition comprising the compounds of Formula (I) and their uses as anti-proliferative and proapoptotic agents for cancer therapy.
    Type: Application
    Filed: November 22, 2016
    Publication date: May 18, 2017
    Inventors: Benedetto Grimaldi, Esther Torrente, Rita Scarpelli, Giovanni Bottegoni, Tiziano Bandiera, Marina Veronesi
  • Multitarget FAAH and COX inhibitors and therapeutical uses thereof
    Patent number: 9630914
    Abstract: Multitarget inhibitors of the enzymes Fatty Acid Amide Hydrolase (FAAH), Cyclooxygenase-1 (COX-1) and/or Cyclooxygenase-2 (COX-2) having a specific carbamate moiety on the meta or ortho position of the A ring of a substituted biphenyl core and having an halogen in the ortho position of the B ring of the biphenyl core. Also concerns the therapeutical application of the multitarget inhibitors, in particular, in the prevention and treatment of cancer.
    Type: Grant
    Filed: August 1, 2013
    Date of Patent: April 25, 2017
    Assignees: Fondazione Istituto Italiano Di Tecnologia, The Regents of the University of California, Alma Mater Studiorum—Universita' Di Bologna
    Inventors: Marco De Vivo, Rita Scarpelli, Andrea Cavalli, Marco Migliore, Daniele Piomelli, Damien Habrant, Angelo Favia
  • Dual Inhibitor Compounds for Use in the Treatment of Neurodegenerative Disorders and Alzheimer's Disease
    Publication number: 20170096406
    Abstract: The present invention relates to Compounds of Formula (I) and pharmaceutical compositions containing the same. It further relates to their use in the prevention or treatment of central nervous system diseases or disorders, in particular, cognitive, neurodegenerative or neuronal diseases or disorders.
    Type: Application
    Filed: June 12, 2015
    Publication date: April 6, 2017
    Inventors: Andrea Cavalli, Federica Prati, Giovanni Bottegoni, Angelo Danilo Favia, Daniela Pizzirani, Rita Scarpelli, Maria Laura Bolognesi
  • Diarylalkylamine REV-ERB antagonists and their use as medicaments
    Patent number: 9611245
    Abstract: The present invention relates to compounds of Formula (I) or pharmaceutically acceptable salts or solvates thereof: It further discloses a pharmaceutical composition comprising the compounds of Formula (I) and their uses as anti-proliferative and pro-apoptotic agents for cancer therapy.
    Type: Grant
    Filed: October 9, 2014
    Date of Patent: April 4, 2017
    Assignee: Fondazione Istituto Italiano Di Tecnologia
    Inventors: Benedetto Grimaldi, Esther Torrente, Rita Scarpelli, Giovanni Bottegoni, Tiziano Bandiera, Marina Veronesi
  • INHIBITORS OF FATTY ACID AMIDE HYDROLASE (FAAH) ENZYME WITH IMPROVED ORAL BIOAVAILABILITY AND THEIR USE AS MEDICAMENTS
    Publication number: 20170088510
    Abstract: Described herein, inter alia, are compositions and methods useful for inhibiting fatty acid amide hydrolase.
    Type: Application
    Filed: October 6, 2016
    Publication date: March 30, 2017
    Inventors: Daniele PIOMELLI, Tiziano BANDIERA, Rita SCARPELLI
  • Acid ceramidase inhibitors and their use as medicaments
    Patent number: 9428465
    Abstract: The present invention concerns, in a first aspect, compounds of Formula I as defined herein, pharmaceutically acceptable salts thereof and pharmaceutical compositions containing such compounds. The present invention also relates to compounds of Formula I for use as acid ceramidase inhibitors, and in the treatment of cancer and other disorders in which modulation of the levels of ceramide is clinically relevant.
    Type: Grant
    Filed: May 27, 2013
    Date of Patent: August 30, 2016
    Assignee: Fondazione Istituto Italiano Di Technologia
    Inventors: Daniele Piomelli, Natalia Realini, Marco Mor, Chiara Pagliuca, Daniela Pizzirani, Rita Scarpelli, Tiziano Bandiera
  • DIARYLALKYLAMINE REV-ERB ANTAGONISTS AND THEIR USE AS MEDICAMENTS
    Publication number: 20160237057
    Abstract: The present invention relates to compounds of Formula (I) or pharmaceutically acceptable salts or solvates thereof: It further discloses a pharmaceutical composition comprising the compounds of Formula (I) and their uses as anti-proliferative and pro-apoptotic agents for cancer therapy.
    Type: Application
    Filed: October 9, 2014
    Publication date: August 18, 2016
    Inventors: Benedetto Grimaldi, Esther Torrente, Rita Scarpelli, Giovanni Bottegoni, Tiziano Bandiera, Marina Veronesi
  • MULTITARGET FAAH AND COX INHIBITORS AND THERAPEUTICAL USES THEREOF
    Publication number: 20150203447
    Abstract: Multitarget inhibitors of the enzymes Fatty Acid Amide Hydrolase (FAAH), Cyclooxygenase-1 (COX-1) and/or Cyclooxygenase-2 (COX-2) having a specific carbamate moiety on the meta or ortho position of the A ring of a substituted biphenyl core and having an halogen in the ortho position of the B ring of the biphenyl core. Also concerns the therapeutical application of the multitarget inhibitors, in particular, in the prevention and treatment of cancer.
    Type: Application
    Filed: August 1, 2013
    Publication date: July 23, 2015
    Applicants: Fondazione Istituti Italiano di Tecnologia, The Regents of the University of California, Alma Mater Studiorum-Universitá di Bologna
    Inventors: Marco De Vivo, Rita Scarpelli, Andrea Cavalli, Marco Migliore, Daniele Piomelli, Damien Habrant, Angelo Favia
  • ACID CERAMIDASE INHIBITORS AND THEIR USE AS MEDICAMENTS
    Publication number: 20150111892
    Abstract: The present invention concerns, in a first aspect, compounds of Formula I as defined herein, pharmaceutically acceptable salts thereof and pharmaceutical compositions containing such compounds. The present invention also relates to compounds of Formula I for use as acid ceramidase inhibitors, and in the treatment of cancer and other disorders in which modulation of the levels of ceramide is clinically relevant.
    Type: Application
    Filed: May 27, 2013
    Publication date: April 23, 2015
    Inventors: Daniele Piomelli, Natalia Realini, Marco Mor, Chiara Pagliuca, Daniela Pizzirani, Rita Scarpelli, Tiziano Bandiera