Abstract: An isolator system includes: a main body case including a substantially box-shaped work space isolated from its surroundings; a spray device configured to spray a sterilizing mist from a nozzle mounted within the main body case, the sterilizing mist being obtained by converting a sterilizing liquid into mist; a diffusion fan mounted within the main body case to diffuse the sterilizing mist; and a control device configured to control operations of the spray device and the diffusion fan, the spray device being configured to spray the sterilizing mist when spraying, the diffusion fan being configured to be intermittently operated in the spray process of the spray device, the diffusion fan being configured to be continuously operated from an end of the spray process of the spray device.