Abstract: The present invention concerns an improved optical method and optical sensing device for determining the levels of polyhydroxyl-substituted organic molecules in vitro and/or in vivo in aqueous media. The range of detection is between about 400 and 800 nm. In particular, a sensory devise is implemented in a mammal to determine sugar levels. Specifically, a dye is combined with a conjugated nitrogen-containing heterocyclic aromatic boronic acid-substituted bis-onium compound in the presence of a sugar, such as fructose or glucose. The viologens are preferred as the aromatic conjugated nitrogen-containing boronic acid substituted compounds. The method is useful to determine sugar levels in a human being.

Abstract: The invention relates to a class of glucose-responsive, polyviologen boronic acid quenchers that may be used in combination with fluophores to achieve real-time measurement of glucose levels in vivo.

Abstract: The present invention concerns an improved optical method and optical sensing device for determining the levels of polyhydroxyl-substituted organic molecules in vitro and/or in vivo in aqueous media. The range of detection is between about 400 and 800 nm. In particular, a sensory devise is implemented in a mammal to determine sugar levels. Specifically, a dye is combined with a conjugated nitrogen-containing heterocyclic aromatic boronic acid-substituted bis-onium compound in the presence of a sugar, such as fructose or glucose. The viologens are preferred as the aromatic conjugated nitrogen-containing boronic acid substituted compounds. The method is useful to determine sugar levels in a human being.

Abstract: Novel pyridinium salts functionalized with boronic acid and methods of making them are disclosed. When combined with a fluorescent dye, the compounds are useful in the detection of polyhydroxyl-substituted organic molecules.

Abstract: Novel optical devices, methods and systems relating to the detection of glucose, and more particularly to real-time glucose monitoring, are disclosed herein. More particularly, various hardware and methodological means are disclosed for ratiometric correction of optical glucose measurements for artifacts of optical systems.

Abstract: In preferred embodiments, the present invention relates to methods for polymerizing a monomer solution within a cavity covered by a porous membrane to generate a smooth polymer surface. More specifically, the method can be used to provide a medical device or sensor with a smooth polymer surface.

Abstract: Embodiments of the present invention are directed to an optical sensor capable of measuring two analytes simultaneously with a single indicator system. In preferred embodiments, the sensor comprises a fluorescent dye having acid and base forms that facilitate ratiometric pH sensing, wherein the dye is further associated with a glucose binding moiety and configured to generate a signal that varies in intensity with the concentration of glucose.

Abstract: The present invention concerns an improved optical method and optical sensing device for determining the levels of polyhydroxyl-substituted organic molecules in vitro and/or in vivo in aqueous media. In particular, a sensory devise is implemented in a mammal to determine sugar levels. Specifically, a dye is combined with a conjugated nitrogen-containing heterocyclic aromatic boronic acid-substituted bis-onium compound in the presence of a sugar, such as fructose or glucose. The viologens are preferred as the aromatic conjugated nitrogen-containing boronic acid substituted compounds. The method is useful to determine sugar levels in a human being.

Abstract: The present invention concerns an improved optical method and optical sensing device for determining the levels of polyhydroxyl-substituted organic molecules in vitro in aqueous or organic media. Specifically, a dye is combined with an conjugated nitrogen-containing aromatic heterocyclic aromatic boronic acid-substituted bis-onium compound in the presence of a sugar, such as fructose or glucose. The viologens are preferred as the aromatic conjugated nitrogen containing boronic acid substituted compounds. The method is useful to determine sugar levels in fermentation and process streams.

Abstract: The present invention concerns an improved optical method and optical sensing device for determining the levels of polyhydroxyl-substituted organic molecules in vivo in aqueous media. Specifically, a dye is combined with a conjugated nitrogen-containing heterocyclic aromatic boronic acid-substituted bis-onium compound in the presence of a sugar, such as fructose or glucose. The viologens are preferred as the aromatic conjugated nitrogen-containing boronic acid substituted compounds. The method is useful to determine sugar levels in a human being.

Abstract: The present invention concerns an improved optical method and optical sensing device for determining the levels of polyhydroxyl-substituted organic molecules in vivo in aqueous media. Specifically, a dye is combined with a conjugated nitrogen-containing heterocyclic aromatic boronic acid-substituted bis-onium compound in the presence of a sugar, such as fructose or glucose. The viologens are preferred as the aromatic conjugated nitrogen-containing boronic acid substituted compounds. The method is useful to determine sugar levels in a human being.

Abstract: The present invention concerns an improved optical method and optical sensing device for determining the levels of polyhydroxyl-substituted organic molecules in vitro in aqueous or organic media. Specifically, a dye is combined with an conjugated nitrogen-containing aromatic heterocyclic aromatic boronic acid-substituted bis-onium compound in the presence of a sugar, such as fructose or glucose. The viologens are preferred as the aromatic conjugated nitrogen containing boronic acid substituted compounds. The method is useful to determine sugar levels in fermentation and process streams.

Abstract: This invention relates to a method of an apparatus and method for separating component gases in a gas mixture employing a glassy polymer membrane at temperatures at or slightly above the freezing point of any liquid present so as to achieve superior separator of gas components. The composition of certain monomers and polymers are claimed.

Abstract: Described is a process for preparing a three-dimensional article of a lyotropic polymer comprising the steps of (a) forming a shaped article of a liquid crystalline solution of a lyotropic polymer; (b) washing the shaped article with a washing fluid under conditions sufficient to reduce the solvent content of the article to less than about 2,000 parts per million, wherein the dimensions of the washed article are no less than 0.05 inches by 0.05 inches by 0.05 inches. Such articles are useful for many applications, particularly those requiring fire- and/or heat-resistance.

Abstract: The present invention further provides a substantially non-aqueous agricultural pesticide concentrate formulation of a non-ionic surfactant and a amphipathic graft copolymer composition in admixture with a water-insoluble organic agricultural pesticide which concentrate formulation can be easily diluted with water to form non-settling, freeze-thaw stable formulations.The present invention further provides methods for the use of water-diluted agricultural pesticide concentrate formulations of the above non-ionic surfactant concentrate formulations in the kill and control of agricultural pest.

Abstract: The present invention further provides a substantially non-aqueous agricultural pesticide concentrate formulation of a non-ionic surfactant and a amphipathic graft copolymer composition in admixture with a water-insoluble organic agricultural pesticide which concentrate formulation can be easily diluted with water to form non-settling, freeze-thaw stable formulations.The present invention further provides methods for the use of water-diluted agricultural pesticide concentrate formulations of the above non-ionic surfactant concentrate formulations in the kill and control of agricultural pest.

Abstract: The unsaturation of a hydroxyl-containing compound can be reduced by reaction with a nitrile oxide compound such as tetramethyl terephthalonitrile, N,N'-dioxide. The reaction of a nitrile oxide with terminal unsaturation associated with the preparation of a polyol from propylene oxide reduces the monol content of the polyol composition.

Abstract: This invention relates to a method of and apparatus for separating component gases in a gas mixture employing a glassy polymer membrane at temperatures of 5.degree. C. or less so as to achieve superior separation of gas components.

Abstract: The invention is a process for the preparation of polybenzazole staple fibers which includes extruding a solution of polybenzazole polymer to form a dope filament, cutting the dope filament to a desired length, and washing and drying the cut filament. It has been discovered that the process of the invention provides a suitable means to prepare staple fibers which does not require the cutting of washed, rigid polybenzazole filaments.

Abstract: Described is a method for preparing a polybenzazole filament which comprises extruding a polybenzazole dope filament, drawing the filament across an air gap, coagulating and washing the filament, and drying the filament, characterized in that a solution of a compound selected from the group consisting of ferrocenes, ruthocene, iodide-, cobalt-, and copper-containing compounds, dyes, and mixtures thereof is contacted with a filament subsequent to the washing step and prior to the drying step. This method provides a means to improve the tensile strength retention of damaged polybenzazole filaments following exposure to sunlight.