Abstract: The present invention provides a method for manufacturing a compound of formula (I) or a pharmaceutically acceptable salt thereof; wherein R1 R2, R4 and X1 are defined herein.

Abstract: A heat transfer system that includes one or more heat exchangers and one or more variable control pumps that control flow through the one or more heat exchangers. At least one variable control pump is on the source side of the heat exchanger for controlling flow of a first circulation medium and at least one flow controlling mechanical device is on the load side of the heat exchanger for controlling flow of a second circulation medium. Sensors are used for detecting variables of the first circulation medium and the second circulation medium. At least one controller is configured to control at least one parameter of the first circulation medium or the second circulation medium by controlling at least one of the variable control pump or the flow controlling mechanical device using a feed forward control loop calculated from the detected variables to achieve control of the at least one parameter.

Abstract: The present invention relates to a stable pharmaceutical composition comprising a fixed dose combination of a therapeutically effective amount of DPP-IV inhibitor and a therapeutically effective amount of SGLT2 inhibitor for reducing blood glucose level in patients with diabetes. The present invention specifically relates to a stable pharmaceutical composition comprising Sitagliptin or a pharmaceutically acceptable salts or solvate or hydrate or premix thereof and Empagliflozin or a pharmaceutically acceptable salt or solvate or hydrate or premix thereof in the presence of one or more pharmaceutically acceptable excipients. Moreover, the present invention relates to a stable pharmaceutical composition comprising Sitagliptin Phosphate Monohydrate, Empagliflozin and one or more pharmaceutically acceptable excipients with high content uniformity, reduced degradation impurities and optimum dissolution.

Abstract: A heat transfer system that includes one or more heat exchangers and one or more control pumps that control flow through the heat exchangers. In order to source a variable load, the control pumps can be controlled to operate at less than full duty flow. In an example embodiment, a controller can calculate, when each heat exchanger is clean, coefficient values of each respective heat exchanger. The controller can determine, during real-time operation, real-time coefficient values of the heat exchanger to compare with the respective coefficient values when clean, in order to determine whether there is fouling in that heat exchanger. In some examples, the controller can determine that maintenance is required on the heat exchanger due to the fouling, and perform flushing of the heat exchanger by operating one or more of the control pumps at full duty load during real-time operation to source the variable load.

Abstract: A heat transfer system that includes one or more heat exchangers and one or more control pumps that control flow through the heat exchangers. In order to source a variable load, the control pumps can be controlled to operate at less than full duty flow. In an example embodiment, a controller can calculate, when each heat exchanger is clean, coefficient values of each respective heat exchanger. The controller can determine, during real-time operation, real-time coefficient values of the heat exchanger to compare with the respective coefficient values when clean, in order to determine whether there is fouling in that heat exchanger. In some examples, the controller can determine that maintenance is required on the heat exchanger due to the fouling, and perform flushing of the heat exchanger by operating one or more of the control pumps at full duty load during real-time operation to source the variable load.

Abstract: A multi-assistant speech-processing system that centrally determines multiple execution plans to respond to a user input. A central component determines whether a particular input should be processed using a requested assistant or a different assistant or should be terminated. Assistant handoff may be determined based on system policies as well as user input-specific data. A ranked list of execution options may be supplemented by augmented data corresponding to messages to a user. The system may attempt to execute plans in the ranked order until a plan succeeds.

Abstract: The present disclosure is directed to simple, efficient and economically viable process for preparing anthranilamide compounds of Formula (I) useful as insecticidal agents for combating harmful pests, such as insects which destroy agricultural plants and crops wherein R is Cl or CN

Abstract: A heat transfer system that includes one or more heat exchangers and one or more variable control pumps that control flow through the one or more heat exchangers. At least one variable control pump is on the source side of the heat exchanger for controlling flow of a first circulation medium and at least one flow controlling mechanical device is on the load side of the heat exchanger for controlling flow of a second circulation medium. Sensors are used for detecting variables of the first circulation medium and the second circulation medium. At least one controller is configured to control at least one parameter of the first circulation medium or the second circulation medium by controlling at least one of the variable control pump or the flow controlling mechanical device using a feed forward control loop calculated from the detected variables to achieve control of the at least one parameter.

Abstract: A heat transfer system that includes one or more heat exchangers and one or more variable control pumps that control flow through the one or more heat exchangers. At least one variable control pump is on the source side of the heat exchanger for controlling flow of a first circulation medium and at least one flow controlling mechanical device is on the load side of the heat exchanger for controlling flow of a second circulation medium. Sensors are used for detecting variables of the first circulation medium and the second circulation medium. At least one controller is configured to control at least one parameter of the first circulation medium or the second circulation medium by controlling at least one of the variable control pump or the flow controlling mechanical device using a feed forward control loop calculated from the detected variables to achieve control of the at least one parameter.

Abstract: The present technology generally relates to metadata based generation and management of event presentations. The technology may include selecting a plurality of target audiences, programmatically generating a plurality of presentations and a presentation plan, programmatically executing the presentation plan, and programmatically adjusting the presentation plan based on monitored efficiency. The adjusting of the presentation plan may be based, for example, on performance of constituent elements of particular presentations relative to other constituent elements, e.g., from other presentations.

Abstract: A heat transfer system that includes one or more heat exchangers and one or more control pumps that control flow through the heat exchangers. In order to source a variable load, the control pumps can be controlled to operate at less than full duty flow. In an example embodiment, a controller can calculate, when each heat exchanger is clean, coefficient values of each respective heat exchanger. The controller can determine, during real-time operation, real-time coefficient values of the heat exchanger to compare with the respective coefficient values when clean, in order to determine whether there is fouling in that heat exchanger. In some examples, the controller can determine that maintenance is required on the heat exchanger due to the fouling, and perform flushing of the heat exchanger by operating one or more of the control pumps at full duty load during real-time operation to source the variable load.

Abstract: Natural disintegrant pre-mixes which are useful for formulating solid dosage forms for oral administration of drugs, vitamins, food supplements, etc. The composition comprises a blend about 20% to about 90% by weight of Psyllium Husk and about 5% to about 60% by weight of Oat Fiber (all weight percentages being based on the dry weight of the disintegrant composition). The composition may further comprise about 1% to about 25% by weight of at least one further component selected from guar gum, Locust bean gum, gum karaya, Aegle marmelose gum, Mangifera indica gum, and a combination thereof and/or about 1% to about 20% by weight of at least one further component selected Apple Fiber, Wheat Fiber, Pea Fiber, Cellulose Powder, Agave Powder, Bamboo Fiber, and a combination thereof (all weight percentages being based on the dry weight of the disintegrant composition).

Abstract: The present technology generally relates to metadata based generation and management of event presentations. The technology may include selecting a plurality of target audiences, programmatically generating a plurality of presentations and a presentation plan, programmatically executing the presentation plan, and programmatically adjusting the presentation plan based on monitored efficiency. The adjusting of the presentation plan may be based, for example, on performance of constituent elements of particular presentations relative to other constituent elements, e.g., from other presentations.

Abstract: A heat transfer system that includes one or more heat exchangers and one or more variable control pumps that control flow through the one or more heat exchangers. At least one variable control pump is on the source side of the heat exchanger for controlling flow of a first circulation medium and at least one flow controlling mechanical device is on the load side of the heat exchanger for controlling flow of a second circulation medium. Sensors are used for detecting variables of the first circulation medium and the second circulation medium. At least one controller is configured to control at least one parameter of the first circulation medium or the second circulation medium by controlling at least one of the variable control pump or the flow controlling mechanical device using a feed forward control loop calculated from the detected variables to achieve control of the at least one parameter.

Abstract: Chewable gelatin formulations that include a bovine gelatin and a fish gelatin.

Abstract: The present technology generally relates to metadata based generation and management of event presentations. The technology may include selecting a plurality of target audiences, programmatically generating a plurality of presentations and a presentation plan, programmatically executing the presentation plan, and programmatically adjusting the presentation plan based on monitored efficiency. The adjusting of the presentation plan may be based, for example, on performance of constituent elements of particular presentations relative to other constituent elements, e.g., from other presentations.

Abstract: The present technology generally relates to content distribution via a network of computing devices. The technology may include presenting online content to users via computer networks, such as the Internet and, more particularly, to methods and systems for establishing relationships between users wherein these relationships are employed to deliver content to users based, e.g., on potential interest in events. The present technology may additionally or alternately be employed, for example, to increase the distribution of content via a network of computing devices, to select and/or manage the presentation of content over the network of computing devices, and to select targets for the presentation of content over the network of computing devices.

Abstract: Solid mixed catalysts and methods for use in conversion of triglycerides and free fatty acids to biodiesel are described. A batch or continuous process may be used with the catalysts for transesterification of triglycerides with an alkyl alcohol to produce corresponding mono carboxylic acid esters and glycerol in high yields and purity. Similarly, alkyl and aryl carboxylic acids and free fatty acids are also converted to corresponding alkyl esters. The described catalysts are thermostable, long lasting, and highly active.

Abstract: Solid mixed catalysts and methods for use in conversion of triglycerides and free fatty acids to biodiesel are described. A batch or continuous process may be used with the catalysts for transesterification of triglycerides with an alkyl alcohol to produce corresponding mono carboxylic acid esters and glycerol in high yields and purity. Similarly, alkyl and aryl carboxylic acids and free fatty acids are also converted to corresponding alkyl esters. The described catalysts are thermostable, long lasting, and highly active.

Abstract: Solid mixed catalysts and methods for use in conversion of triglycerides and free fatty acids to biodiesel are described. A batch or continuous process may be used with the catalysts for transesterification of triglycerides with an alkyl alcohol to produce corresponding mono carboxylic acid esters and glycerol in high yields and purity. Similarly, alkyl and aryl carboxylic acids and free fatty acids are also converted to corresponding alkyl esters. The described catalysts are thermostable, long lasting, and highly active.