Patents by Inventor Riyong LIU

Riyong LIU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ARGININE DEIMINASE MUTANT, COVALENT DIMER AND CONJUGATE AND USE THEREOF
    Publication number: 20260234595
    Abstract: Provided are an arginine deiminase mutant, a covalent dimer and a conjugate and a use thereof. The provided arginine deiminase mutant forms a covalent disulfide bond between arginine deiminase subunits by means of mutation of an amino acid site on arginine deiminase. Also provided are a covalent conjugate and a use in the field of cancer treatment. Site-directed mutagenesis of an amino acid site promotes formation of a covalent disulfide bond between non-covalent homodimeric arginine deiminase subunits, and a formed dimer has a more stable structure; in addition, the exposure level of an epitope on an interaction interface can be reduced, the in vivo immunogenicity is reduced, and a more excellent anti-tumor effect is exhibited.
    Type: Application
    Filed: January 26, 2024
    Publication date: August 13, 2026
    Applicant: PEG-BIO BIOPHARM CO., LTD. (CHONGQING)
    Inventors: Kai Fan, Yunfeng He, Riyong Liu, Qi Zhang, Guanghui Tang, Tangwei Nie, Qiong Ding, Haiyan Wen, Yanmin Bai, Qing Chen
  • STABILIZER FOR URATE OXIDASE AND PEGYLATED CONJUGATE THEREOF, AND PHARMACEUTICAL USE OF STABILIZER
    Publication number: 20260117204
    Abstract: Provided is a method for improving the stability of urate oxidase. The inventors have discovered that combining an active ingredient urate oxidase or chemically modified urate oxidase with a stabilizer xanthine through a non-covalent bond can significantly improve the in vivo and in vitro stability of urate oxidase and chemically modified urate oxidase in the form of a tetramer, thereby effectively improving the stability of urate oxidase.
    Type: Application
    Filed: December 29, 2025
    Publication date: April 30, 2026
    Applicants: Hangzhou Grand Biologic Pharmaceutical Inc., Peg-Bio Biopharm Co., Ltd. (Chongqing)
    Inventors: Qian WANG, Kai FAN, Yu WANG, Riyong LIU, Hongying WANG, Chunlan HU, Tianwen YAN, Yunfeng HE, Guowei SU, Zhicheng FU, Xupeng DING, Ying XU, Zeyu CHEN, Hui ZHANG, Yatong ZHOU
  • METHOD FOR PREPARING POLYETHYLENE GLYCOL-MODIFIED URATE OXIDASE
    Publication number: 20230346896
    Abstract: Provided is a method for preparing a polyethylene glycol-modified urate oxidase, at least 11 of the following amino acid sites of the polyethylene glycol-modified urate oxidase have a PEG modification: T1, K3, K4, K30, K35, K76, K79, K97, K112, K116, K120, K152, K179, K222, K231, K266, K272, K285, K291, and K293, and the preparation method includes: performing a coupling reaction between urate oxidase and polyethylene glycol, wherein the polyethylene glycol is provided in the form of an acidic solution, and a molar ratio of the urate oxidase to the polyethylene glycol is 1: (56 to 94), to obtain the polyethylene glycol-modified urate oxidase.
    Type: Application
    Filed: May 4, 2023
    Publication date: November 2, 2023
    Applicant: HANGZHOU GRAND BIOLOGIC PHARMACEUTICAL INC.
    Inventors: RIYONG LIU, Zhiming WANG, Yunfeng HE, Yu WANG, Zhicheng FU, Tianwen YAN, Chunlan HU, Guowei SU, Changcheng TAN, Xupeng DING, Hui YANG, Hongying WANG, Qiong DING, Qian WANG, Haiyan WEN, Kai FAN
  • URATE OXIDASE PREPARATION AND USE THEREOF
    Publication number: 20230346959
    Abstract: Provided is a urate oxidase preparation. The urate oxidase preparation includes polyethylene glycol-modified urate oxidase as an active ingredient and a buffer reagent as an excipient.
    Type: Application
    Filed: May 4, 2023
    Publication date: November 2, 2023
    Applicant: HANGZHOU GRAND BIOLOGIC PHARMACEUTICAL INC.
    Inventors: Yunfeng HE, Zhiming WANG, Zhicheng FU, Yu WANG, Haiyan WEN, Tianwen YAN, Chunlan HU, Guowei SU, Riyong LIU, Xupeng DING, Kai FAN, Hongying WANG, Qian WANG
  • POLYETHYLENE GLYCOL-MODIFIED URATE OXIDASE
    Publication number: 20220054598
    Abstract: The present disclosure provides a polyethylene glycol-modified urate oxidase. At least 11 of the following amino acid sites in the urate oxidase have a PEG modification: T1, K3, K4, K30, K35, K76, K79, K97, K112, K116, K120, K152, K179, K222, K231, K266, K272, K285, K291, and K293.
    Type: Application
    Filed: November 9, 2021
    Publication date: February 24, 2022
    Inventors: Kai FAN, Zhiming WANG, Riyong LIU, Yu WANG, Yunfeng HE, Tianwen YAN, Zhicheng FU, Guowei SU, Chunlan HU, Xupeng DING, Changcheng TAN, Hongying WANG, Hui YANG, Qiong DING, Haiyan WEN