Patents by Inventor Roald Skurtveit
Roald Skurtveit has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7892522Abstract: Ultrasound contrast agents comprising microbubbles of biocompatible gas, e.g. a sulphur halide or a perfluorocarbon, stabilized by opsonisable amphiphilic material, e.g. a membrane-forming lipid such as a phospholipid, especially a negatively charged phospholipid such as a phosphatidylserine, may exhibit prolonged contrast-generating residence time in the liver following intravenous administration.Type: GrantFiled: September 13, 2001Date of Patent: February 22, 2011Assignee: GE Healthcare ASInventors: David Johnson, Jonny Østensen, Morten Eriksen, Audun Tornes, Sigmund Frigstad, Harald Dugstad, Jo Klaveness, Pål Rongved, Roald Skurtveit, Jorunn Brænden
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Publication number: 20090191131Abstract: The present invention relates to a method of imaging of an animate human or non-human animal body, which method comprises: administering parenterally to said body a particulate material comprising a matrix or membrane material and at least one contrast generating species, which matrix or membrane material is responsive to a pre-selected physiological parameter whereby to alter the contrast efficacy of said species in response to a change in the value of said parameter; generating image data of at least part of said body in which said species is present; and generating therefrom a signal indicative of the value or variation of said parameter in said part of said body. The invention also relates to contrast media for imaging a physiological parameter.Type: ApplicationFiled: January 15, 2009Publication date: July 30, 2009Inventors: Sigrid Lise Fossheim, Jo Klaveness, Atle Bjornerud, Pal Rongved, Klaes Golman, Roald Skurtveit
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Publication number: 20050201942Abstract: Microbubble dispersions stabilised by phospholipids predominantly comprising molecules which individually have an overall net charge exhibit advantageous stability, rendering them useful as efficacious contrast agents. An improved process for preparing microbubble-containing contrast agents is also disclosed, this comprising lyophilising an aqueous dispersion of gas microbubbles stabilised by one or more membrane-forming lipids to yield a dried product which may be reconstituted in an injectable carrier liquid to generate a microbubble-containing contrast agent.Type: ApplicationFiled: March 4, 2005Publication date: September 15, 2005Inventors: Harald Dugstad, Jo Klaveness, Pal Rongved, Roald Skurtveit, Jorunn Braenden
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Publication number: 20050136002Abstract: The present invention relates to a method of imaging of an animate human or non-human animal body, which method comprises: administering parenterally to said body a particulate material comprising a matrix or membrane material and at least one contrast generating species, which matrix or membrane material is responsive to a pre-selected physiological parameter whereby to alter the contrast efficacy of said species in response to a change in the value of said parameter; generating image data of at least part of said body in which said species is present; and generating therefrom a signal indicative of the value or variation of said parameter in said part of said body. The invention also relates to contrast media for imaging a physioloogical parameter.Type: ApplicationFiled: September 21, 2004Publication date: June 23, 2005Inventors: Sigrid Fossheim, Jo Klaveness, Atle Bjornerud, Pal Rongved, Klaes Golman, Roald Skurtveit
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Publication number: 20040197392Abstract: The invention relates to pH-sensitive liposome systems, compositions comprising said pH sensitive liposome systems and the use of such compositions as contrast agents and medicaments.Type: ApplicationFiled: January 8, 2004Publication date: October 7, 2004Inventors: Knut-Egil Loekling, Roald Skurtveit, Sigrid Lise Fossheim
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Publication number: 20040170564Abstract: Ultrasonic visualisation of a subject, particularly of perfusion in the myocardium and other tissues, is performed using novel gas-containing contrast agent preparations which provide controllable and temporary growth of the gas phase in vitro following administration and can therefore act as deposited perfusion tracers. The preparations comprise an injectable aqueous gas dispersion and an administrable substance or substances capable of destabilising the dispersed gas to provide temporary growth thereof. In cardiac perfusion imaging the preparations may advantageously be coadministered with vasodilator drugs such as adenosine in order to enhance the differences between return signal intensity from normal and hypoperfused myocardial tissue respectively.Type: ApplicationFiled: November 19, 2003Publication date: September 2, 2004Inventors: Roald Skurtveit, Olaug Hjelstuen, Jonny Ostensen
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Publication number: 20040146462Abstract: Ultrasonic visualisation of a subject, particularly of perfusion in the myocardium and other tissues, is performed using novel gas-containing contrast agent preparations which promote controllable and temporary growth of the gas phase in vivo following administration and can therefore act as deposited perfusion tracers. The preparations comprise an injectable aqueous medium comprising dispersed gas and an injectable oil-in-water emulsion in which the oil phase comprises a diffusible component capable of diffusion in vivo into the dispersed gas to promote temporary growth thereof, such that material present at the surfaces of the dispersed gas phase and material present at the surfaces of the dispersed oil phase have affinity for each other, e.g. as a result of having opposite charges.Type: ApplicationFiled: November 19, 2003Publication date: July 29, 2004Inventors: Morten Eriksen, Helge Tolleshaug, Roald Skurtveit, Alan Cuthbertson, Jonny Ostensen, Sigmund Frigstad, Pal Rongved
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Publication number: 20040131547Abstract: Ultrasound contrast agents of the phase shift colloid type, comprising emulsions of volatile oils in water, are provided with gas-containing nucleation sites associated with (e.g. within) droplets of the dispersed oil phase, in order to enhance efficacy and control of the liquid-to-gas phase transition.Type: ApplicationFiled: November 21, 2003Publication date: July 8, 2004Inventors: Balin Balinov, Roald Skurtveit, Unni Nordby Wiggen, Jonny Ostensen
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Publication number: 20030202942Abstract: Microbubble dispersions stabilised by phospholipids predominantly comprising molecules which individually have an overall net charge exhibit advantageous stability, rendering them useful as efficacious contrast agents. An improved process for preparing microbubble-containing contrast agents is also disclosed, this comprising lyophilising an aqueous dispersion of gas microbubbles stabilised by one or more membrane-forming lipids to yield a dried product which may be reconstituted in an injectable carrier liquid to generate a microbubble-containing contrast agent.Type: ApplicationFiled: November 22, 2002Publication date: October 30, 2003Inventors: Harald Dugstad, Jo Klaveness, Pal Rongved, Roald Skurtveit, Jorunn Braenden
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Publication number: 20020106328Abstract: Ultrasound contrast agents comprising microbubbles of biocompatible gas, e.g. a sulphur halide or a perfluorocarbon, stabilized by opsonisable amphiphilic material, e.g. a membrane-forming lipid such as a phospholipid, especially a negatively charged phospholipid such as a phosphatidylserine, may exhibit prolonged contrast-generating residence time in the liver following intravenous administration.Type: ApplicationFiled: September 13, 2001Publication date: August 8, 2002Inventors: David Johnson, Jonny Ostensen, Morten Eriksen, Audun Tornes, Sigmund Frigstad, Harald Dugstad, Jo Klaveness, Pal Rongved, Roald Skurtveit, Jorunn Braenden
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Publication number: 20020039556Abstract: The stability of phospholipid compositions is enhanced by the inclusion of a buffer system comprising ammonia or a water soluble amine having a pH at 15° C. of less than or equal to 9.5.Type: ApplicationFiled: October 19, 2001Publication date: April 4, 2002Inventors: Kari Dyvik, Harald Dugstad, Jo Klaveness, Roald Skurtveit, Jonny Ostensen, Kiyoto Yachi
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Patent number: 6274120Abstract: Microparticulate contrast agents comprising gas or a gas precursor encapsulated by a non-polymeric and non-polymerisable wall-forming material are readily characterisable materials exhibiting surprising structural integrity and stability.Type: GrantFiled: October 14, 1999Date of Patent: August 14, 2001Assignee: Nycomed Imaging ASInventors: Harald Dugstad, Per Antonius Foss, Jo Klaveness, Pål Rongved, Roald Skurtveit, Jan Solberg, Inger Reidun Fjeldskaar Aukrust
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Publication number: 20010010811Abstract: Microbubble dispersions stabilized by phospholipids predominantly comprising molecules which individually have an overall net charge exhibit advantageous stability, rendering them useful as efficacious contrast agents. An improved process for preparing microbubble-containing contrast agents is also disclosed, this comprising lyophilising an aqueous dispersion of gas microbubbles stabilized by one or more membrane-forming lipids to yield a dried product which may be reconstituted in an injectable carrier liquid to generate a microbubble-containing contrast agent.Type: ApplicationFiled: February 15, 2001Publication date: August 2, 2001Inventors: Harald Dugstad, Jo Klaveness, Pal Rongved, Roald Skurtveit, Jorunn Braenden
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Patent number: 6221337Abstract: Microbubble dispersions stabilised by phospholipids predominantly comprising molecules which individually have an overall net charge exhibit advantageous stability, rendering them useful as efficacious contrast agents. An improved process for preparing microbubble-containing contrast agents is also disclosed, this comprising lyophilising an aqueous dispersion of gas microbubbles stabilised by one or more membrane-forming lipids to yield a dried product which may be reconstituted in an injectable carrier liquid to generate a microbubble-containing contrast agent.Type: GrantFiled: August 19, 1998Date of Patent: April 24, 2001Assignee: Nycomed Imaging ASInventors: Harald Dugstad, Jo Klaveness, Pål Rongved, Roald Skurtveit, Jorunn Brænden
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Patent number: 6217850Abstract: Microbubble dispersions stabilised by phospholipids predominantly comprising molecules which individually have an overall net charge exhibit advantageous stability, rendering them useful both as efficacious contrast agents per se and as intermediates in the preparation of contrast agents wherein the phospholipids are crosslinked or polymerised. An improved process for preparing microbubble-containing contrast agents is also disclosed, this comprising lyophilising an aqueous dispersion of gas microbubbles stabilised by one or more membrane-forming lipids to yield a dried product which may be reconstituted in an injectable carrier liquid to generate a microbubble-containing contrast agent.Type: GrantFiled: May 26, 1998Date of Patent: April 17, 2001Assignee: Nycomed Imaging ASInventors: Harald Dugstad, Jo Klaveness, Pål Rongved, Roald Skurtveit, Jorunn Braenden
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Patent number: 6177061Abstract: A contrast agent for use in diagnostic studies, particularly ultrasound imaging, comprising a dispersion in an injectable aqueous medium of a biocompatible azeotropic mixture which is in gaseous form at 37° C., at least one component of said mixture being a halocarbon having a molecular weight of at least 100.Type: GrantFiled: October 21, 1999Date of Patent: January 23, 2001Assignee: Nycomed Imaging ASInventors: Jo Klaveness, Roald Skurtveit, Pål Rongved, Lars Hoff
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Patent number: 6106806Abstract: Ultrasound contrast agents having microbubbles of gas or a gas precursor encapsulated by non-proteinaceous crosslinked or polymerised amphiphilic moieties, e.g. in the form of micelles, exhibit good stability in vivo upon administration and may if desired incorporate biodegradable linkages so as to possess particular desired levels of biodegradability.Type: GrantFiled: June 7, 1995Date of Patent: August 22, 2000Assignee: Nycomed Imaging ASInventors: Jo Klaveness, Hanno Priebe, P.ang.l Rongved, Lars Stubberud, Roald Skurtveit, Harald Dugstad
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Patent number: 5990263Abstract: Novel extended polymer surfactants comprising a methoxy-terminated polyethylene glycol hydrophilic block acylated with a hydrophobic moiety comprising a chain of at least two fatty acid units, e.g. an acyloxyacyl group such as 16-hexadecanoyloxyhexadecanoyl, are useful in the preparation of polymer-based gas-containing contrast agents by emulsion techniques.Type: GrantFiled: March 4, 1996Date of Patent: November 23, 1999Assignee: Nycomed Imaging ASAInventors: Harald Dugstad, P.ang.l Rongved, Roald Skurtveit
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Patent number: 5919434Abstract: The present invention relates to polymer-based gas-containing contrast agents in which microbubbles of gas are encapsulated by non-polymerizable wall-forming block or graft copolymer surfactants. The polymer surfactants are preferably biodegradable and include block and graft copolymers containing linkages of formula (I):--(O).sub.m --CO--O--C(R.sup.1 R.sup.2)--O--CO--(O).sub.n --(I)where R.sup.1 and R.sup.2 each represent a hydrogen atom or a carbon-attached monovalent organic group, or R.sup.1 and R.sup.2 together form a carbon-attached divalent organic group and m and n are each zero or 1.Type: GrantFiled: March 14, 1997Date of Patent: July 6, 1999Assignee: Nycomed Imaging ASInventors: Harald Dugstad, Per Antonius Foss, Jo Klaveness, P.ang.l Rongved, Roald Skurtveit