Patents by Inventor Rob Hooft Van Huijsduijnen

Rob Hooft Van Huijsduijnen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NIK Inhibitors cell-based screening assay
    Publication number: 20140234870
    Abstract: The present invention relates to a cell-based assay for the screening and the identification of inhibitors of NIK protein. The method according to the present invention allows the identification of compounds that inhibit NIK activity related to the phosphorylation of IKK1. The assay combines the use of transfected Human Embryonic Kidney (HEK) cells with a non-radioactive, homogeneous proximity assay using an “acceptor” bead and a “donor” bead.
    Type: Application
    Filed: July 26, 2012
    Publication date: August 21, 2014
    Applicant: Merck Patent GmbH
    Inventors: Rob Hooft Van Huijsduijnen, Sheraz Gul
  • Sulfonamide Derivatives for the Treatment of Bacterial Infections
    Publication number: 20090018169
    Abstract: This present invention is related to sulfonamide derivatives of Formula (I), pharmaceutical composition thereof, methods of preparation thereof and to their use for the treatment and/or prophylaxis of bacterial infections such as tuberculosis.
    Type: Application
    Filed: February 9, 2007
    Publication date: January 15, 2009
    Applicant: Laboratoires Serono SA
    Inventors: Jerome Gonzalez, Dominique Swinnen, Agnes Bombrun, Rob Hooft Van Huijsduijnen, Timothy Wells
  • Glepp-1 Inhibitors in the Treatment of Autoimmune and/or Inflammatory Disorders
    Publication number: 20080207722
    Abstract: The present invention is related to the use of a Glepp-1 inhibitor for the manufacture of a medicament for the treatment of an autoimmune and/or an inflammatory disorder.
    Type: Application
    Filed: July 14, 2006
    Publication date: August 28, 2008
    Applicant: LABORATORIES SERONO SA
    Inventors: Agnes Bombrun, Rob Hooft Van Huijsduijnen, Catherine Jorand-Lebrun, Pierre-Alain Vitte, Patrick Gerber
  • Use of methylene amide derivatives in cardiovascular disorders
    Publication number: 20070185118
    Abstract: The present invention is related to the use of substituted methylene amide derivatives of Formula (I) for the treatment and/or prevention of cardiovascular disorders such as coronary obstruction and heart failure. In particular, the present invention is related to the use of substituted methylene amide derivatives of Formula (I) in particular for the treatment and/or prevention of endothelial dysfunction in heart failure.
    Type: Application
    Filed: February 25, 2005
    Publication date: August 9, 2007
    Applicant: APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.
    Inventors: Rob Hooft Van Huijsduijnen, Vincent Richard
  • Automated method for identifying related biomolecular sequences
    Patent number: 6996474
    Abstract: The invention relate to an automated method for identifying related biomolecular sequences having defined features of interest from databases, the databases comprising at least a first and a second set of sequences, each set being derived from a different type of organism, comprising the steps of: a) establishing from the first set of sequences a non-redundant list of query sequences having the defined features of interest (first family members), using a database search program; b) performing sequence alignments with the first family members in a second set of sequences derived from a second type of organism, using a database search program and a preset similarity threshold, giving a list of second family members: c) establishing a two dimensional matrix displaying the first and second family members and their respective similarity values resulting from step (b), optionally displaying only those second family members having similarity values exceeding a preset threshold value; d) selecting from the matrix tho
    Type: Grant
    Filed: November 16, 2000
    Date of Patent: February 7, 2006
    Assignee: Applied Research Systems ARS Holding N.V.
    Inventors: Jacques Colinge, Rob Hooft Van Huijsduijnen