Patents by Inventor Rob Kaiser

Rob Kaiser has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Minor groove binder (MGB)-oligonucleotide miRNA antagonists
    Patent number: 9334495
    Abstract: Compositions and methods for inhibiting the actions of non-coding RNAs such as miRNAs and piRNAs are provided. The compositions comprise single or double stranded oligonucleotides conjugated with Minor Groove Binders (“MGBs”). The oligonucleotides can vary in length, can contain nucleotides having one or more modifications, and have regions that are substantially complementary to one or more mature miRNAs or piRNAs.
    Type: Grant
    Filed: November 23, 2010
    Date of Patent: May 10, 2016
    Assignee: ELITECHGROUP B.V.
    Inventors: Anastasia Khvorova, Annaleen Vermeulen, Rob Kaiser, Jon Karpilow, Nicolaas M. J. Vermeulen, Walt Mahoney
  • Minor groove binder (MGB)-oligonucleotide miRNA antagonists
    Patent number: 8980855
    Abstract: Compositions and methods for inhibiting the actions of non-coding RNAs such as miRNAs and piRNAs are provided. The compositions comprise single or double stranded oligonucleotides conjugated with Minor Groove Binders (“MGBs”). The oligonucleotides can vary in length, can contain nucleotides having one or more modifications, and have regions that are substantially complementary to one or more mature miRNAs or piRNAs.
    Type: Grant
    Filed: June 7, 2012
    Date of Patent: March 17, 2015
    Assignees: Elitech Holding B.V., GE Healthcare Dharmacon, Inc.
    Inventors: Anastasia Khvorova, Annaleen Vermeulen, Rob Kaiser, Jon Karpilow, Nicolaas M. J. Vermeulen, Walt Mahoney
  • Tripartite oligonucleotide complexes and methods for gene silencing by RNA interference
    Patent number: 8809514
    Abstract: Provided herein are tripartite oligonucleotide complexes which can be administered to a cell, tissue or organism to silence a target gene. The tripartite oligonucleotide complexes of the disclosure may include a conjugate moiety that facilitates delivery to a cell, tissue or organism without the aid of a transfection reagent.
    Type: Grant
    Filed: September 20, 2007
    Date of Patent: August 19, 2014
    Assignee: GE Healthcare Dharmacon, Inc.
    Inventors: Christina Yamada, Anastasia Khvorova, Rob Kaiser, Emily Anderson, Devin Leake
  • Duplex oligonucleotide complexes and methods for gene silencing by RNA interference
    Patent number: 8501706
    Abstract: Provided herein are duplex oligonucleotide complexes which can be administered to a cell, tissue or organism to silence a target gene without the aid of a transfection reagent(s). The duplex oligonucleotide complexes of the disclosure include a conjugate moiety that facilitates delivery to a cell, tissue or organism.
    Type: Grant
    Filed: July 19, 2012
    Date of Patent: August 6, 2013
    Assignee: Dharmacon, Inc.
    Inventors: Christina Yamada, Anastasia Khvorova, Rob Kaiser, Emily Anderson, Devin Leake
  • MINOR GROOVE BINDER (MGB)-OLIGONUCLEOTIDE MIRNA ANTAGONISTS
    Publication number: 20120245219
    Abstract: Compositions and methods for inhibiting the actions of non-coding RNAs such as miRNAs and piRNAs are provided. The compositions comprise single or double stranded oligonucleotides conjugated with Minor Groove Binders (“MGBs”). The oligonucleotides can vary in length, can contain nucleotides having one or more modifications, and have regions that are substantially complementary to one or more mature miRNAs or piRNAs.
    Type: Application
    Filed: June 7, 2012
    Publication date: September 27, 2012
    Applicants: DHARMACON, INC., ELITECH HOLDING B.V.
    Inventors: Anastasia Khvorova, Annaleen Vermeulen, Rob Kaiser, Jon Karpilow, Nicolaas M.J. Vermeulen, Walt Mahoney
  • Duplex oligonucleotide complexes and methods for gene silencing by RNA interference
    Patent number: 8252755
    Abstract: Provided herein are duplex oligonucleotide complexes which can be administered to a cell, tissue or organism to silence a target gene without the aid of a transfection reagent(s). The duplex oligonucleotide complexes of the disclosure include a conjugate moiety that facilitates delivery to a cell, tissue or organism.
    Type: Grant
    Filed: September 20, 2007
    Date of Patent: August 28, 2012
    Assignee: Dharmacon, Inc.
    Inventors: Christina Yamada, Anastasia Khvorova, Rob Kaiser, Emily Anderson, Devin Leake
  • MINOR GROOVE BINDER (MGB)-OLIGONUCLEOTIDE MIRNA ANTAGONISTS
    Publication number: 20110172289
    Abstract: Compositions and methods for inhibiting the actions of non-coding RNAs such as miRNAs and piRNAs are provided. The compositions comprise single or double stranded oligonucleotides conjugated with Minor Groove Binders (“MGBs”). The oligonucleotides can vary in length, can contain nucleotides having one or more modifications, and have regions that are substantially complementary to one or more mature miRNAs or piRNAs.
    Type: Application
    Filed: November 23, 2010
    Publication date: July 14, 2011
    Inventors: Anastasia Khvorova, Annaleen Vermeulen, Rob Kaiser, Jon Karpilow, Nicolaas M.J. Vermeulen, Walt Mahoney
  • TRIPARTITE OLIGONUCLEOTIDE COMPLEXES AND METHODS FOR GENE SILENCING BY RNA INTERFERENCE
    Publication number: 20100093085
    Abstract: Provided herein are tripartite oligonucleotide complexes which can be administered to a cell, tissue or organism to silence a target gene.
    Type: Application
    Filed: September 20, 2007
    Publication date: April 15, 2010
    Applicant: DHARMACON, INC
    Inventors: Christina Yamada, Anastasia Khvorova, Rob Kaiser, Emily Anderson, Devin Leake