Patents by Inventor Rob Steendam
Rob Steendam has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20240033221Abstract: According to various aspects of this disclosure, the present disclosure relates to long-acting, shelf-stable microsphere formulations of bupivacaine, kits, and methods for treating or preventing pain by parenteral injection of a microsphere formulation of bupivacaine.Type: ApplicationFiled: April 22, 2021Publication date: February 1, 2024Inventors: Shankar HARIHARAN, Suketu SANGHVI, Rahul SURANA, Maarten van DIJK, Ivan TERZIC, Kimberly Aniek BANUS, Thanh NGUYEN, Rob STEENDAM
-
Publication number: 20230137010Abstract: The present disclosure is directed to formulations, devices, kits, and methods for treating or preventing motor symptoms associated with Parkinson's disease by injection of a microsphere formulation of apomorphine free base or a pharmaceutically acceptable a salt thereof, wherein injection can be from a pre-filled injector.Type: ApplicationFiled: April 12, 2021Publication date: May 4, 2023Inventors: Shankar HARIHARAN, Suketu SANGHVI, Suneel GUPTA, Rahul SURANA, Ivan TERZIC, Albert DOORNBOS, Rob STEENDAM
-
Publication number: 20220409730Abstract: The present disclosure relates to dosage forms for extended release of an antibody or large protein. The extended release dosage forms comprise a biodegradable multi-block copolymer matrix and provide for extended release of antibody or large protein over a desired time period.Type: ApplicationFiled: October 30, 2020Publication date: December 29, 2022Applicant: InnoCore Technologies Holding B.V.Inventors: Rob STEENDAM, Maria COIMBRA, Joana Catarina RIBEIRO ARAUJO, Johan ZUIDEMA, Tanja HENZLER, Alexandra KROG
-
Publication number: 20220332900Abstract: The invention is directed to a biodegradable, phase separated, thermoplastic multi-block copolymer, to a process for preparing a biodegradable, phase separated, thermoplastic multi-block copolymer, to the use of a biodegradable, semi-crystalline, phase separated, thermoplastic multi-block copolymer, and to a composition for the delivery of at least one biologically active compound to a host. The biodegradable, phase separated, thermoplastic multi-block copolymer of the invention comprises at least one amorphous hydrolysable pre-polymer (A) segment and at least one semi-crystalline hydrolysable pre-polymer (B) segment, wherein said multi-block copolymer under physiological conditions has a Tg of 37° C. or less and a Tm of 50-110° C.Type: ApplicationFiled: September 30, 2020Publication date: October 20, 2022Applicant: InnoCore Technologies Holding B.V.Inventors: Henk HAITJEMA, Rob STEENDAM, Christine HIEMSTRA, Johan ZUIDEMA, Albert DOORNBOS, Thanh NGUYEN
-
Publication number: 20220331258Abstract: Provided herein are poly(ether ester) multi-block copolymers (PEE-MBCP). Also provided herein are injectable delivery systems or pharmaceutical compositions, comprising a PEE-MBCP provided herein, either alone or in combination with a binding protein, such as abicipar. Also provided herein are methods of using these injectable delivery systems or pharmaceutical compositions provided herein for the treatment of ocular disorders.Type: ApplicationFiled: September 30, 2020Publication date: October 20, 2022Applicant: Allergan Sales, LLCInventors: Patrick Hughes, Hongwen Rivers, Jie Shen, Johan Zuidema, Henk Haitjema, Christine Hiemstra, Rob Steendam
-
Publication number: 20220062177Abstract: The present disclosure relates to extended release dosage forms of human chorionic gonadotropin (hCG) or derivatives or isoforms thereof. The extended release hCG dosage forms comprise biodegradable polymer microspheres and provide for extended release of hCG over a desired time period.Type: ApplicationFiled: October 2, 2019Publication date: March 3, 2022Applicants: InnoCore Technologies Holding B.V., MHB Labs, Inc.Inventors: Johan ZUIDEMA, Rob STEENDAM, Joana Catarina Ribeiro ARAUJO, Ravi KACKER, Abraham MORGENTALER
-
Patent number: 10300019Abstract: This invention is directed to a biodegradable, semi-crystalline, phase separated thermoplastic multi-block copolymer, a process for preparing said multi-block copolymer, a composition for the delivery of at least one biological active compound, and to a method for delivering a biologically active compound to a subject in need thereof. A multi-block copolymer of the invention is characterized in that: a) it comprises at least one hydrolysable pre-polymer (A) segment and at least one hydrolysable pre-polymer (B) segment, b) said multi-block copolymer having a Tg of 37° C. or less and a Tm of 110-250° C. under physiological conditions; c) the segments are linked by a multifunctional chain-extender; d) the segments are randomly distributed over the polymer chain; e) at least part of the pre-polymer (A) segment is derived from a water-soluble polymer.Type: GrantFiled: August 15, 2017Date of Patent: May 28, 2019Assignee: InnoCore Technologies B.V.Inventors: Rob Steendam, Theodorus Adrianus Cornelius Flipsen, Christine Hiemstra, Johan Zuidema
-
Publication number: 20180085318Abstract: This invention is directed to a biodegradable, semi-crystalline, phase separated thermoplastic multi-block copolymer, a process for preparing said multi-block copolymer, a composition for the delivery of at least one biological active compound, and to a method for delivering a biologically active compound to a subject in need thereof. A multi-block copolymer of the invention is characterised in that: a) it comprises at least one hydrolysable pre-polymer (A) segment and at least one hydrolysable pre-polymer (B) segment, b) said multi-block copolymer having a Tg of 37° C. or less and a Tm of 110-250° C. under physiological conditions; c) the segments are linked by a multifunctional chain-extender; d) the segments are randomly distributed over the polymer chain; e) at least part of the pre-polymer (A) segment is derived from a water-soluble polymer.Type: ApplicationFiled: August 15, 2017Publication date: March 29, 2018Applicant: InnoCore Technologies B.V.Inventors: Rob STEENDAM, Theodorus Adrianus Cornelius FLIPSEN, Christine HIEMSTRA, Johan ZUIDEMA
-
Patent number: 9364442Abstract: The invention is directed to biodegradable, thermoplastic, phase separated segmented multi-block copolymers. The copolymers of the present invention find use in various biomedical applications as well as in pharmaceutical applications. Provided is a composition for the controlled release of at least one biologically active polypeptide to a host, comprising the at least one biologically active polypeptide encapsulated in a matrix comprising at least one phase separated, thermoplastic multi-block copolymer, the copolymer being characterized in that (i) it comprises at least two hydrolysable segments chosen from prepolymer (A) and prepolymer (B), prepolymer (A) having a Tg lower than 37° C. and prepolymer (B) having a Tm of 40° C.-100° C. under physiological conditions; (ii) the segments being linked by a multifunctional chain-extender; (iii) the segments are randomly distributed over the polymer chain; and (iv) prepolymer (A) contains a segment that is derived from a water soluble polymer.Type: GrantFiled: July 8, 2011Date of Patent: June 14, 2016Assignee: INNOCORE TECHNOLOGIES B.V.Inventors: Rob Steendam, Theodorus Adrianus Cornelius Flipsen, Christine Hiemstra, Johan Zuidema
-
Publication number: 20140199385Abstract: This invention is directed to a biodegradable, semi-crystalline, phase separated thermoplastic multi-block copolymer, a process for preparing said multi-block copolymer, a composition for the delivery of at least one biological active compound, and to a method for delivering a biologically active compound to a subject in need thereof. A multi-block copolymer of the invention is characterised in that: a) it comprises at least one hydrolysable pre-polymer (A) segment and at least one hydrolysable pre-polymer (B) segment, b) said multi-block copolymer having a Tg of 37° C. or less and a Tm of 110-250° C. under physiological conditions; c) the segments are linked by a multifunctional chain-extender; d) the segments are randomly distributed over the polymer chain; e) at least part of the pre-polymer (A) segment is derived from a water-soluble polymer.Type: ApplicationFiled: July 23, 2012Publication date: July 17, 2014Applicant: INNOCORE TECHNOLOGIES B.V.Inventors: Rob Steendam, Theodorus Adrianus Cornelius Flipsen, Christine Hiemstra, Johan Zuidema
-
Patent number: 8674032Abstract: The invention relates to a biodegradable multi-block copolymer, comprising at least two hydrolysable segments derived from pre-polymers A and B, which segments are linked by a multi-functional chain-extender and are chosen from the pre-polymers A and B, and triblock copolymers ABA and BAB, wherein the multi-block copolymer is amorphous at physiological (body) conditions. The invention further relates to a process for preparing said copolymer and to its use as a medical implant, a coating for a medical device or a drug delivery vehicle.Type: GrantFiled: June 6, 2013Date of Patent: March 18, 2014Assignee: Innocore Technologies B.V.Inventors: Catharina Everdina Hissink, Rob Steendam, Ronald Meyboom, Theodorus Adrianus Cornelius Flipsen
-
Publication number: 20130273284Abstract: The invention relates to a biodegradable multi-block copolymer, comprising at least two hydrolysable segments derived from pre-polymers A and B, which segments are linked by a multi-functional chain-extender and are chosen from the pre-polymers A and B, and triblock copolymers ABA and BAB, wherein the multi-block copolymer is amorphous at physiological (body) conditions. The invention further relates to a process for preparing said copolymer and to its use as a medical implant, a coating for a medical device or a drug delivery vehicle.Type: ApplicationFiled: June 6, 2013Publication date: October 17, 2013Applicant: INNOCORE TECHNOLOGIES BVInventors: Catharina Everdina HISSINK, Rob STEENDAM, Ronald MEYBOOM, Theodorus Adrianus Cornelius FLIPSEN
-
Publication number: 20130209568Abstract: The invention is directed to biodegradable, thermoplastic, phase separated segmented multi-block copolymers. The copolymers of the present invention find use in various biomedical applications as well as in pharmaceutical applications. Provided is a composition for the controlled release of at least one biologically active polypeptide to a host, comprising the at least one biologically active polypeptide encapsulated in a matrix comprising at least one phase separated, thermoplastic multi-block copolymer, the copolymer being characterized in that (i) it comprises at least two hydrolysable segments chosen from prepolymer (A) and prepolymer (B), prepolymer (A) having a Tg lower than 37° C. and prepolymer (B) having a Tm of 40° C.-100° C. under physiological conditions; (ii) the segments being linked by a multifunctional chain-extender; (iii) the segments are randomly distributed over the polymer chain; and (iv) prepolymer (A) contains a segment that is derived from a water soluble polymer.Type: ApplicationFiled: July 8, 2011Publication date: August 15, 2013Applicant: INNOCORE TECHNOLOGIES B.V.Inventors: Rob Steendam, Theodorus Adrianus Cornelius Flipsen, Christine Hiemstra, Johan Zuidema
-
Patent number: 8481651Abstract: The invention relates to a biodegradable multi-block copolymer, comprising at least two hydrolysable segments derived from pre-polymers A and B, which segments are linked by a multi-functional chain-extender and are chosen from the pre-polymers A and B, and triblock copolymers ABA and BAB, wherein the multi-block copolymer is amorphous at physiological (body) conditions. The invention further relates to a process for preparing said copolymer and to its use as a medical implant, a coating for a medical device or a drug delivery vehicle.Type: GrantFiled: January 14, 2005Date of Patent: July 9, 2013Assignee: Innocore Technologies B.V.Inventors: Catharina Everdina Hissink, Rob Steendam, Ronald Meyboom, Theodorus Adrianus Cornelius Flipsen
-
Patent number: 8309137Abstract: The present invention relates to specific DL-lactide-?-caprolactone copolymers and the application of these polymers in the production of biodegradable medical applications. According to the present invention a polymeric material comprising poly(DL-lactide-co-?-caprolactone) is provided, which is obtained by the copolymerization of DL-lactide and ?-caprolactone, having a lactide content of 51-75 mol %, most preferably of 62-69 mol %.Type: GrantFiled: July 22, 2010Date of Patent: November 13, 2012Assignee: Polyganics BVInventors: Catharina Everdina Hissink, Theodorus Adrianus Cornelius Flipsen, Hans Wicher Kuijper, Rob Steendam
-
Patent number: 8187254Abstract: The invention relates, generally, to medical appliances. More particularly, it relates to tubular shaped devices used as drains for draining fluids (liquids and/or gases) from antrums or other parts of the human or animal body. According to the present invention a drain is provided, which is suitable for draining a human or animal antrum, which drain comprises a synthetic biodegradable material, preferably a biodegradable polymer.Type: GrantFiled: November 3, 2003Date of Patent: May 29, 2012Assignee: Polyganics B.V.Inventors: Catharina Everdina Hissink, Rob Steendam, Linda Joan Gibcus, Johan Zuidema
-
Publication number: 20100312340Abstract: The present invention relates to specific DL-lactide-?-caprolactone copolymers and the application of these polymers in the production of biodegradable medical applications. According to the present invention a polymeric material comprising poly(DL-lactide-co-?-caprolactone) is provided, which is obtained by the copolymerization of DL-lactide and ?-caprolactone, having a lactide content of 51-75 mol %, most preferably of 62-69 mol %. The materials of the present invention have excellent mechanical properties and may be used to provide articles for medical application, in particular nerve guides.Type: ApplicationFiled: July 22, 2010Publication date: December 9, 2010Applicant: Polyganics BVInventors: Catharina Everdina Hissink, Theodorus Adrianus C. Flipsen, Hans Wicher Kuijper, Rob Steendam
-
Patent number: 7785628Abstract: The present invention relates to specific DL-lactide-?-caprolactone copolymers and the application of these polymers in the production of biodegradable medical applications. According to the present invention a polymeric material comprising poly(DL-lactide-co-?-caprolactone) is provided, which is obtained by the copolymerization of DL-lactide and ?-caprolactone, having a lactide content of 51-75 mol %, most preferably of 62-69 mol %. The materials of the present invention have excellent mechanical properties and may be used to provide articles for medical application, in particular nerve guides.Type: GrantFiled: December 2, 2002Date of Patent: August 31, 2010Assignee: Polyganics BVInventors: Catharina Everdina Hissink, Theodorus Adrianus C. Flipsen, Hans Wicher Kuijper, Rob Steendam
-
Publication number: 20070155906Abstract: The invention relates to a biodegradable multi-block copolymer, comprising at least two hydrolysable segments derived from pre-polymers A and B, which segments are linked by a multi-functional chain-extender and are chosen from the pre-polymers A and B, and triblock copolymers ABA and BAB, wherein the multi-block copolymer is amorphous at physiological (body) conditions. The invention further relates to a process for preparing said copolymer and to its use as a medical implant, a coating for a medical device or a drug delivery vehicle.Type: ApplicationFiled: January 14, 2005Publication date: July 5, 2007Inventors: Catharina Hissink, Rob Steendam, Ronald Meyboom, Theodorus Flipsen
-
Publication number: 20060142736Abstract: The invention relates, generally, to medical appliances. More particularly, it relates to tubular shaped devices used as drains for draining fluids (liquids and/or gases) from antrums or other parts of the human or animal body. According to the present invention a drain is provided, which is suitable for draining a human or animal antrum, which drain comprises a synthetic biodegradable material, preferably a biodegradable polymer.Type: ApplicationFiled: November 3, 2003Publication date: June 29, 2006Inventors: Catharina Hissink, Rob Steendam, Linda Gibcus, Johan Zuidema