Abstract: A medical device is disclosed for tissue, body lumen and/or cavity closure inside a body of a patient. In one particular application, the medical device can be used for minimally invasive access and closure of a left atrial appendage of the heart. The medical device generally includes a tool used for grasping the appendage, a closure member, and at least one tool to deploy, control, and position the closure member for closing the appendage. The device can also include an expander tool for expanding the working area around the left atrial appendage to improve visibility during the procedure. In other embodiments, the medical device may include other tools, for example an imaging tool for viewing the target area and/or other tools that are considered useful in a left atrial appendage closure procedure.