Abstract: An electronic data interface overlay for modifying existing formulary data is provided along with systems and methods for the same. The overlay comprises member-specific clinical data and causes automatic generation of code(s) indicating coverage denial upon querying of treatments of the existing formulary data associated with certain of the member-specific clinical data, such as pharmacogenetic (“PGx”) test results, of the data interface overlay. The formulary data includes alternative treatments which may be suggested and approved upon denial based on PGx test results. An electronic health record is automatically updated with the alternative treatment.

Abstract: System and methods for alerting a healthcare provider to prescribed treatments having reduced or no effectiveness due to genetic composition is provided. A database containing treatments known to have reduced or no efficacy in persons having particular genetic markers is queried to determine whether any treatments prescribed by, or likely to be prescribed by, a healthcare provider to the patient are known to have reduced or no efficacy in persons having the same certain genetic markers as the patient. An alert indicating such information is displayed at a healthcare provider system.

Abstract: System and methods for providing interoperable, automated, real-time genetic efficacy contraindication checks are provided. Coverage requests involving for medications for patients from nodes of an electronic network. A testing results query is made for each request at database(s) with identifying information for the patients to determine if genetic efficacy testing results are available. If so, a testing results query is performed to determine if any of the medications in a respective coverage request are contraindicated for a respective patient based on the genetic efficacy testing results. And, if so, a standardized, encoded message is returned to the originating node for the respective coverage request query indicating each contraindicated medication.

Abstract: System and methods for automating preauthorization of genetic efficacy testing with prescription dispensation are provided. Coverage requests for medicines are received from pharmacy systems. Databases are queried to retrieve policy rules for the coverage requests. A coverage decision analysis is performed and where an associated medication is otherwise approved for coverage and where genetic efficacy testing is available for the associated medication, a prior authorization for such genetic efficacy testing is automatically generated and included with which is transmitted together with an approval of coverage decision to a requesting one of said number of pharmacy systems.

Abstract: System and methods for suggesting insurance eligible genetic tests to a healthcare provider are disclosed. An EMR system is queried to retrieve insurance information, active medications, and diagnoses associated with a particular patient. An eligibility database is queried to retrieve insurance eligibly rules for a particular policy of a particular insurance providers based on the retrieved insurance information. A laboratory information system (“LIS”) applies the retrieved insurance eligibility rules to the retrieved active medications and diagnoses to determine eligible genetic tests. An electronic notification comprising an order form for each of the eligible genetic tests is transmitted from the LIS to the EMR.

Abstract: System and methods for alerting a healthcare provider to prescribed treatments having reduced or no effectiveness due to genetic composition is provided. A database containing treatments known to have reduced or no efficacy in persons having particular genetic markers is queried to determine whether any treatments prescribed by, or likely to be prescribed by, a healthcare provider to the patient are known to have reduced or no efficacy in persons having the same certain genetic markers as the patient. An alert indicating such information is displayed at a healthcare provider system.

Abstract: A system and method for alerting a healthcare provider to ineffective prescribed medications is provided. A laboratory system receives test results with genetic markers for a patient, queries a database containing medications known to be ineffective in persons having particular genetic markers to determine whether any medications prescribed by, or likely to be prescribed by, a healthcare provider to the patient are known to be ineffective in persons having the same genetic markers as the patient, and transmits an alert containing such information to a healthcare provider system for the healthcare provider.

Abstract: System and methods for preventing the coverage or fill of ineffective medications are provided. Genetic efficacy testing results are received at a pharmacy benefits manager (“PBM”) system from a laboratory information system. Medications reported as ineffective in the testing results are flagged as an allergy in an electronic patient record. Requests for coverage of medications are received at the PBM system from a dispensing pharmacy system and electronic notifications are issued to the dispensing pharmacy system where the medication is flagged as an allergy at the PBM system to prevent the flagged medication from being filled.

Abstract: System and methods for alerting a healthcare provider to prescribed treatments having reduced or no effectiveness due to genetic composition is provided. A database containing treatments known to have reduced or no efficacy in persons having particular genetic markers is queried to determine whether any treatments prescribed by, or likely to be prescribed by, a healthcare provider to the patient are known to have reduced or no efficacy in persons having the same genetic markers as the patient. An alert containing such information is displayed at a healthcare provider system.

Abstract: System and methods for alerting a healthcare provider to prescribed treatments having reduced or no effectiveness due to genetic composition is provided. A database containing treatments known to have reduced or no efficacy in persons having particular genetic markers is queried to determine whether any treatments prescribed by, or likely to be prescribed by, a healthcare provider to the patient are known to have reduced or no efficacy in persons having the same genetic markers as the patient. An alert containing such information is displayed at a healthcare provider system.

Abstract: System and methods for providing laboratory-based authorization of genetic testing are disclosed. An order for genetic testing is received from an electronic health record (“EHR”) system at a laboratory information system (“LIS”). A prior authorization request is automatically generated at the LIS from data parsed from the order and retrieved from the EHR and sent to a prior authorization provider. If a patient responsibility amount returned to the LIS is below a threshold, testing proceeds. If the patient responsibility amount is above the threshold, an electronic call center request is generated and the patient is contacted to obtain payment. If a billing consent is not obtained, the specimen for the order is destroyed.

Abstract: System and methods for automating preauthorization of genetic efficacy testing with prescription dispensation are provided. Coverage requests for medicines are received from pharmacy systems. Databases are queried to retrieve policy rules for the coverage requests. A coverage decision analysis is performed and where an associated medication is otherwise approved for coverage and where genetic efficacy testing is available for the associated medication, a prior authorization for such genetic efficacy testing is automatically generated and included with which is transmitted together with an approval of coverage decision to a requesting one of said number of pharmacy systems.

Abstract: System and methods for providing laboratory-based authorization of genetic testing are disclosed. An order for genetic testing is received from an electronic health record (“EHR”) system at a laboratory information system (“LIS”). A prior authorization request is automatically generated at the LIS from data parsed from the order and retrieved from the EHR and sent to a prior authorization provider. If a patient responsibility amount returned to the LIS is below a threshold, testing proceeds. If the patient responsibility amount is above the threshold, an electronic call center request is generated and the patient is contacted to obtain payment. If a billing consent is not obtained, the specimen for the order is destroyed.

Abstract: System and methods for providing enhanced patient updates to facilitate precision therapy are provided. Medical information is received from a transmitting one of a number of electronic health records (“EHR”) systems at a laboratory information system (“LIS”). Where the received medical information comprises prescribed medications designated as ineffective or undereffective for the particular patient based on a retrieved genetic testing results for the patient, the EHR systems are instructed to designate the prescribed medications as an allergy. Where the received medical information comprises new diagnosis information eligible for genetic testing based on retrieved eligibility rules for the particular patient, a suggested order is transmitted to the transmitting EHR system.

Abstract: System and methods for preventing the coverage or fill of ineffective medications are provided. Genetic efficacy testing results are received at a pharmacy benefits manager (“PBM”) system from a laboratory information system. Medications reported as ineffective in the testing results are flagged as an allergy in an electronic patient record. Requests for coverage of medications are received at the PBM system from a dispensing pharmacy system and electronic notifications are issued to the dispensing pharmacy system where the medication is flagged as an allergy at the PBM system to prevent the flagged medication from being filled.

Abstract: System and methods for providing laboratory-based authorization of genetic testing are disclosed. An order for genetic testing is received from an electronic health record (“EHR”) system at a laboratory information system (“LIS”). A prior authorization request is automatically generated at the LIS from data parsed from the order and retrieved from the EHR and sent to a prior authorization provider. If a patient responsibility amount returned to the LIS is below a threshold, testing proceeds. If the patient responsibility amount is above the threshold, an electronic call center request is generated and the patient is contacted to obtain payment. If a billing consent is not obtained, the specimen for the order is destroyed.

Abstract: System and methods for suggesting insurance eligible genetic tests to a healthcare provider are disclosed. An EMR system is queried to retrieve insurance information, active medications, and diagnoses associated with a particular patient. An eligibility database is queried to retrieve insurance eligibly rules for a particular policy of a particular insurance providers based on the retrieved insurance information. A laboratory information system (“LIS”) applies the retrieved insurance eligibility rules to the retrieved active medications and diagnoses to determine eligible genetic tests. An electronic notification comprising an order form for each of the eligible genetic tests is transmitted from the LIS to the EMR.

Abstract: System and methods for alerting a healthcare provider to prescribed treatments having reduced or no effectiveness due to genetic composition is provided. A database containing treatments known to have reduced or no efficacy in persons having particular genetic markers is queried to determine whether any treatments prescribed by, or likely to be prescribed by, a healthcare provider to the patient are known to have reduced or no efficacy in persons having the same genetic markers as the patient. An alert containing such information is displayed at a healthcare provider system.

Abstract: A system and method for alerting a healthcare provider to ineffective prescribed medications is provided. A laboratory system receives test results with genetic markers for a patient, queries a database containing medications known to be ineffective in persons having particular genetic markers to determine whether any medications prescribed by, or likely to be prescribed by, a healthcare provider to the patient are known to be ineffective in persons having the same genetic markers as the patient, and transmits an alert containing such information to a healthcare provider system for the healthcare provider.

Abstract: A locking mechanism is provided for use with at least one door and/or window (10) of a structure, the mechanism comprising at least one operating handle (12) and at least one electrical operating device (14). The operating device may comprise a fob (14) which may be manually operated, e.g. by a householder, from outside a building, to unlock a door or window. In a preferred embodiment, the locking mechanism comprises a first rotatable member (23) associated with the handle, a second rotatable member (24) spaced from the first rotatable member (23) and associated with a dead bold (18) and a control member (28) extending between the first and second rotatable members.