Abstract: The present disclosure is directed to 3,4-dihydroquinolin-2(1H)-one compounds, including compounds of Formula (I) where the substituents are as described herein. The present disclosure is also directed to methods of using these compounds as Artemis endonuclease inhibitors and modulators, particularly for the treatment of cancer and the treatment of severe combined immunodeficiency.

Abstract: Systems and methods are provided for customizing a payment device with a video game related image. One such method comprises receiving, at an online store executing on a computer including a computer readable medium and processor, an achievement message indicating an achievement earned by a user and further including an achievement image and user data. The method further comprises receiving, at the online store, a request from the user to purchase a payment device. The request indicates the achievement image associated to be displayed on the payment device. The method further comprises generating, by the online store, a representation of the payment device configured to display the achievement image.