Patents by Inventor Robbie G. Majzner

Robbie G. Majzner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CHIMERIC ANTIGEN RECEPTOR (CAR) SIGNALING MOLECULES FOR CONTROLLED AND SPECIFIC CAR T CELL ACTIVITY
    Publication number: 20240139320
    Abstract: The present disclosure generally relates to, inter alia, chimeric antigen receptors (CARs) that contain an intracellular signaling domain without an immune receptor tyrosine based activation motif (ITAM). The disclosure also provides compositions and methods useful for producing such molecules, as well as methods for the detection and treatment of diseases, such as cancer.
    Type: Application
    Filed: February 23, 2022
    Publication date: May 2, 2024
    Inventors: Robbie G. Majzner, Aidan Tousley, Louai Labanieh, Crystal L. Mackall, Maria Caterina Rotiroti
  • CHIMERIC ANTIGEN RECEPTORS WITH CD2 ACTIVATION
    Publication number: 20230183312
    Abstract: Disclosed are chimeric antigen receptors comprising a CD2 co-stimulatory domain that retain function against CD58? and CD58low tumor cells, and CD2 co-stimulatory receptors that promote CAR function against CD58? and CD58low tumor cells.
    Type: Application
    Filed: February 12, 2021
    Publication date: June 15, 2023
    Inventors: Robbie G. MAJZNER, Crystal L. MACKALL, Aidan TOUSLEY, Michelle MONJE-DEISSEROTH, Louai LABANIEH, Christopher MOUNT
  • CHIMERIC ANTIGEN RECEPTORS TARGETING GLYPICAN-2
    Publication number: 20220315665
    Abstract: The present disclosure generally relates to, inter alia, antibodies and chimeric antigen receptors (CARs) that bind a Glypican 2 (GPC2) antigen. The disclosure also provides compositions and methods useful for producing such antibodies and CARs, as well as methods for the diagnosis, prevention, and/or treatment of health conditions associated with the GPC2 antigen expression.
    Type: Application
    Filed: May 6, 2020
    Publication date: October 6, 2022
    Inventors: Sabine HEITZENEDER, Robbie G. MAJZNER, Crystal L. MACKALL, John M. MARIS, Kristopher R. BOSSE, Dimiter S. DIMITROV, Zhongyu ZHU
  • ENHANCEMENT OF POLYPEPTIDES AND CHIMERIC ANTIGEN RECEPTORS VIA HINGE DOMAINS
    Publication number: 20220218751
    Abstract: The present disclosure generally relates to, inter alia, novel chimeric polypeptides and chimeric antigen receptors (CARs) that include a hinge domain from CD28 and optionally a costimulatory domain not from CD28. The disclosure also provides compositions and methods useful for producing such molecules, as well as methods for the detection and treatment of diseases, such as cancer.
    Type: Application
    Filed: May 6, 2020
    Publication date: July 14, 2022
    Inventors: Robbie G. Majzner, Crystal L. Mackall, Louai Labanieh, Skyler P. Rietberg