Patents by Inventor Robbie Woodman

Robbie Woodman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Scaffold polypeptides for heterologous peptide display
    Patent number: 8481491
    Abstract: The present invention relates to the use of Stefin A as a scaffold protein for the display of inserted peptides, particularly wherein the Stefin A is a human Stefin A. Several mutations are advantageously made in the wild type stefin A sequence to improve it as a scaffold; preferably the Stefin A comprises a heterologous peptide insertion at the Leu 73 site. Furthermore, preferably the scaffold protein comprises a V48D mutation; preferably the scaffold protein comprises a G4W mutation. Preferably the scaffold comprises Leu73, V48D and G4W mutations. The invention also relates to the scaffold proteins themselves, in particular a stefin A polypeptide having the Leu73, V48D and G4W mutations, such as shown as SEQ ID NO: 1. The invention also relates to a method for identifying binding proteins and to peptide A (RLNKPLPSLPV, SEQ ID NO: 30) and its use in treating yeast infections.
    Type: Grant
    Filed: September 23, 2011
    Date of Patent: July 9, 2013
    Assignee: Medical Research Council
    Inventors: Robbie Woodman, Johannes Tsung-Han Yeh, Sophie Laurenson, Paul Ko Ferrigno
  • SCAFFOLD POLYPEPTIDES FOR HETEROLOGOUS PEPTIDE DISPLAY
    Publication number: 20120190819
    Abstract: The present invention relates to the use of Stefin A as a scaffold protein for the display of inserted peptides, particularly wherein the Stefin A is a human Stefin A. Several mutations are advantageously made in the wild type stefin A sequence to improve it as a scaffold; preferably the Stefin A comprises a heterologous peptide insertion at the Leu 73 site. Furthermore, preferably the scaffold protein comprises a V48D mutation; preferably the scaffold protein comprises a G4W mutation. Preferably the scaffold comprises Leu73, V48D and G4W mutations. The invention also relates to the scaffold proteins themselves, in particular a stefin A polypeptide having the Leu73, V48D and G4W mutations, such as shown as SEQ ID NO: 1. The invention also relates to a method for identifying binding proteins and to peptide A (RLNKPLPSLPV) and its use in treating yeast infections.
    Type: Application
    Filed: September 23, 2011
    Publication date: July 26, 2012
    Applicant: MEDICAL RESEARCH COUNCIL
    Inventors: Robbie Woodman, Johannes Tsung-Han Yeh, Sophie Laurenson, Paul Ko Ferrigno
  • Scaffold polypeptides for heterologous peptide display
    Patent number: 8063019
    Abstract: The present invention relates to the use of Stefin A as a scaffold protein for the display of inserted peptides, particularly wherein the Stefin A is a human Stefin A. Several mutations are advantageously made in the wild type stefin A sequence to improve it as a scaffold; preferably the Stefin A comprises a heterologous peptide insertion at the Leu 73 site. Furthermore, preferably the scaffold protein comprises a V48D mutation; preferably the scaffold protein comprises a G4W mutation. Preferably the scaffold comprises Leu73, V48D and G4W mutations. The invention also relates to the scaffold proteins themselves, in particular a stefin A polypeptide having the Leu73, V48D and G4W mutations, such as shown as SEQ ID NO: 1. The invention also relates to a method for identifying binding proteins and to peptide A (RLNKPLPSLPV) and its use in treating yeast infections.
    Type: Grant
    Filed: June 8, 2006
    Date of Patent: November 22, 2011
    Assignee: Medical Research Council
    Inventors: Robbie Woodman, Johannes Tsung-Han Yeh, Sophie Laurenson, Paul Ko Ferrigno
  • Scaffold
    Publication number: 20080207509
    Abstract: The present invention relates to the use of Stefin A as a scaffold protein for the display of inserted peptides, particularly wherein the Stefin A is a human Stefin A. Several mutations are advantageously made in the wild type stefin A sequence to improve it as a scaffold; preferably the Stefin A comprises a heterologous peptide insertion at the Leu 73 site. Furthermore, preferably the scaffold protein comprises a V48D mutation; preferably the scaffold protein comprises a G4W mutation. Preferably the scaffold comprises Leu73, V48D and G4W mutations. The invention also relates to the scaffold proteins themselves, in particular a stefin A polypeptide having the Leu73, V48D and G4W mutations, such as shown as SEQ ID NO: 1. The invention also relates to a method for identifying binding proteins and to peptide A (RLNKPLPSLPV) and its use in treating yeast infections.
    Type: Application
    Filed: June 8, 2006
    Publication date: August 28, 2008
    Applicant: MEDICAL RESEARCH COUNCIL
    Inventors: Robbie Woodman, Johannes Tsung-Hau Yeh, Sophie Laurenson, Paul Ko Ferrigno